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Diesel motor exhaust and lung cancer mortality: reanalysis of a cohort study in potash miners

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Abstract

The aim of the reanalysis is to reassess lung cancer risk associated with occupational exposure to diesel motor exhaust in potash miners, while controlling for potential confounders such as smoking and previous occupational history. Our investigation is based on a cohort study of nearly 6,000 German potash miners, who were followed up from 1970 to 2001. The reanalysis also takes into account the employment periods before potash mining, in particular uranium mining. Different approaches (nested case–control study and Cox model) were used to adjust for confounding. The exposure estimates were recalculated, lagging the exposure by 5 years. Exposure groups were defined by tertiles of cumulative respirable elemental carbon (REC) exposure estimates and occupational categories, where exposure was estimated originally by representative measurements of total carbon for different occupations. The highest REC concentration was measured for production workers, about twice as much as for other occupations. The reanalysis revealed that while about 4 % of all study subjects had worked earlier in uranium mines, 10.3 % of later lung cancer cases did so. Although their absolute number was small, the corresponding relative risk estimator was significantly elevated. Our analysis did not show any notable association between cumulative REC exposure and lung cancer risk. Introducing cumulative REC exposure as a continuous variable into the conditional logistic regression model yielded an odds ratio of OR = 1.04 [0.70–1.53]95 % adjusted for smoking and previous employment. The study results give no evidence for an association between REC exposure and lung cancer risk. Only for very high cumulative dose, corresponding to at least 20 years of exposure in the production area, some weak hints for a possible risk increase could be detected. The study underlines the importance of assessing the entire occupational history in occupational studies, especially if the supposed dose–response-relationship is weak.

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References

  1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893–917.

    Article  PubMed  CAS  Google Scholar 

  2. IARC (International Agency for Research on Cancer). IARC monographs on the evaluation of carcinogenic risks to humans. Diesel and gasoline engine exhausts and some nitroarenes. International Agency for Research on Cancer. IARC Monogr Eval Carcinog Risks Hum. 1989;46:1–458.

  3. Benbrahim-Tallaa L, Baan RA, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, Guha N, Loomis D, Straif K. International agency for research on cancer monograph working group. Carcinogenicity of diesel-engine and gasoline-engine exhausts and some nitroarenes. Lancet Oncol. 2012;13(7):663–4.

    Google Scholar 

  4. Attfield MD, Schleiff PL, Lubin JH, Blair A, Stewart PA, Vermeulen R, Coble JB, Silverman DT. The diesel exhaust in miners study: a cohort mortality study with emphasis on lung cancer. J Natl Cancer Inst. 2012;104(11):869–83.

    Article  PubMed  CAS  Google Scholar 

  5. Silverman DT, Samanic CM, Lubin JH, Blair AE, Stewart PA, Vermeulen R, Coble JB, Rothman N, Schleiff PL, Travis WD, Ziegler RG, Wacholder S, et al. The diesel exhaust in miners study: a nested case-control study of lung cancer and diesel exhaust. J Natl Cancer Inst. 2012;104(11):855–68.

    Article  PubMed  CAS  Google Scholar 

  6. Garshick E, Laden F, Hart JE, Davis ME, Eisen EA, Smith TJ. Lung cancer and elemental carbon exposure in trucking industry workers. Environ Health Perspect. 2012;120(9):1301–6.

    Article  PubMed  Google Scholar 

  7. Möhner M, Kersten N, Gellissen J. RE: the diesel exhaust in miners study: a nested case-control study of lung cancer and diesel exhaust and a cohort mortality study with emphasis on lung cancer. J Natl Cancer Inst. 2012;104(23):1846–7.

    Google Scholar 

  8. Gamble JF, Nicolich MJ, Boffetta P. Lung cancer and diesel exhaust: an updated critical review of the occupational epidemiology literature. Crit Rev Toxicol. 2012;42(7):549–98.

    Article  PubMed  CAS  Google Scholar 

  9. Morfeld P. Diesel exhaust in miners study: how to understand the findings? J Occup Med Toxicol. 2012;7(1):10.

    Article  PubMed  CAS  Google Scholar 

  10. Olsson AC, Gustavsson P, Kromhout H, Peters S, Vermeulen R, Brüske I, Pesch B, Siemiatycki J, Pintos J, Brüning T, Cassidy A, Wichmann HE, et al. Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada. Am J Respir Crit Care Med. 2011;183(7):941–8.

    Article  PubMed  Google Scholar 

  11. Pronk A, Coble J, Stewart PA. Occupational exposure to diesel engine exhaust: a literature review. J Expo Sci Environ Epidemiol. 2009;19(5):443–57.

    Article  PubMed  CAS  Google Scholar 

  12. Säverin R, Bräunlich A, Dahmann D, Enderlein G, Heuchert G. Diesel exhaust and lung cancer mortality in potash mining. Am J Ind Med. 1999;36(4):415–22.

    Article  PubMed  Google Scholar 

  13. Neumeyer-Gromen A, Razum O, Kersten N, Seidler A, Zeeb H. Diesel motor emissions and lung cancer mortality-results of the second follow-up of a cohort study in potash miners. Int J Cancer. 2009;124(8):1900–6.

    Article  PubMed  CAS  Google Scholar 

  14. Dahmann D, Fricke HH, Bauer HD. Diesel engine emissions in workplace-atmospheres in Germany. Occup Hyg. 1996;3:255–62.

    CAS  Google Scholar 

  15. Grosche B, Kreuzer M, Kreisheimer M, Schnelzer M, Tschense A. Lung cancer risk among German male uranium miners: a cohort study, 1946–1998. Br J Cancer. 2006;95(9):1280–7.

    Article  PubMed  CAS  Google Scholar 

  16. Bergdahl IA, Jonsson H, Eriksson K, Damber L, Jarvholm B. Lung cancer and exposure to quartz and diesel exhaust in Swedish iron ore miners with concurrent exposure to radon. Occup Environ Med. 2010;67(8):513–8.

    Article  PubMed  CAS  Google Scholar 

  17. Wismut GmbH. Chronik der Wismut (CD-ROM). Chemnitz: Wismut GmbH; 1999.

    Google Scholar 

  18. Korn EL, Graubard BI, Midthune D. Time-to-event analysis of longitudinal follow-up of a survey: choice of the time-scale. Am J Epidemiol. 1997;145(1):72–80.

    Article  PubMed  CAS  Google Scholar 

  19. Breslow NE, Lubin J, Marek P, Langholz B. Multiplicative models and cohort analysis. J Am Stat Assoc. 1983;78(381):1–12.

    Article  Google Scholar 

  20. Thiebaut AC, Benichou J. Choice of time-scale in Cox’s model analysis of epidemiologic cohort data: a simulation study. Stat Med. 2004;23(24):3803–20.

    Article  PubMed  Google Scholar 

  21. Möhner M, Stabenow R, Eisinger B. Atlas der Krebsinzidenz in der DDR 1961–1989. Berlin: Ullstein-Mosby; 1994.

    Google Scholar 

  22. StataCorp. Stata: Release 12. Statistical software. College Station: StataCorp LP; 2011.

  23. Akaike H. A new look at the statistical model identification. IEEE Trans Autom Control. 1974;19(6):716–23.

    Article  Google Scholar 

  24. Pearce N, Checkoway H, Kriebel D. Bias in occupational epidemiology studies. Occup Environ Med. 2007;64(8):562–8.

    Article  PubMed  Google Scholar 

  25. Walsh L, Tschense A, Schnelzer M, Dufey F, Grosche B, Kreuzer M. The influence of radon exposures on lung cancer mortality in German uranium miners, 1946–2003. Radiat Res. 2010;173(1):79–90.

    Article  PubMed  CAS  Google Scholar 

  26. Schnelzer M, Hammer GP, Kreuzer M, Tschense A, Grosche B. Accounting for smoking in the radon-related lung cancer risk among German uranium miners: results of a nested case-control study. Health Phys. 2010;98(1):20–8.

    Article  PubMed  CAS  Google Scholar 

  27. Miller BG, Buchanan D, Hurley JF, Hutchison PA, Soutar CA, Pillemer SR, Robertson A. The effects of exposure to diesel fumes, low-level radiation, and respirable dust and quartz, on cancer mortality in coalminers. 1997. Report No.: TM/97/04.

  28. Johnston AM, Buchanan D, Robertson A, Miller BG. Investigation of the possible association between exposure to diesel exhaust particulates in British coalmines and lung cancer. Edinburgh: IOM; 1997. Report No.: TM/97/08.

  29. Garshick E, Laden F, Hart JE, Rosner B, Davis ME, Eisen EA, Smith TJ. Lung cancer and vehicle exhaust in trucking industry workers. Environ Health Perspect. 2008;116(10):1327–32.

    Article  PubMed  Google Scholar 

  30. Laden F, Hart JE, Smith TJ, Davis ME, Garshick E. Cause-specific mortality in the unionized U.S. trucking industry. Environ Health Perspect. 2007;115(8):1192–6.

    Article  PubMed  Google Scholar 

  31. Straif K, Olsson AC, Gustavsson P, Kromhout H, Peters S, Vermeulen R, Brüske I, Pesch B, Brüning T, Kendzia B, Siemiatycki J, Pintos J, et al. Diesel motor exhaust and lung cancer risk in SYNERGY: pooled analysis of case-control studies on the joint effects of occupational carcinogens in the development of lung cancer. Occup Environ Med. 2010;60(Suppl 1):A25.

    Google Scholar 

  32. Möhner M. The impact of selection bias due to increasing response rates among population controls in occupational case-control studies. Am J Respir Crit Care Med. 2012;185(1):104–6.

    PubMed  Google Scholar 

  33. Apostolopoulos Y, Sonmez S, Shattell MM, Belzer M. Worksite-induced morbidities among truck drivers in the United States. AAOHN J. 2010;58(7):285–96.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division Work and Health, Federal Institute for Occupational Safety and Health (BAuA), Nöldnerstr. 40-42, 10317, Berlin, Germany

    Matthias Möhner, Norbert Kersten & Johannes Gellissen

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  1. Matthias Möhner
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  2. Norbert Kersten
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  3. Johannes Gellissen
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Correspondence to Matthias Möhner.

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Möhner, M., Kersten, N. & Gellissen, J. Diesel motor exhaust and lung cancer mortality: reanalysis of a cohort study in potash miners. Eur J Epidemiol 28, 159–168 (2013). https://doi.org/10.1007/s10654-013-9784-0

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  • DOI: https://doi.org/10.1007/s10654-013-9784-0

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