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Paris Prospective Study III: a study of novel heart rate parameters, baroreflex sensitivity and risk of sudden death

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Abstract

Resting heart rate has been related to the risk of cardiovascular disease and sudden death in several large prospective studies. To investigate prospectively the association of novel heart rate parameters and of carotid artery stiffness with sudden death and other cardiovascular disease. The Paris Prospective Study III (PPS3) is a new, ongoing French prospective study. From June 2008 to December 2011, 10,000 men and women aged 50–75 years who will have a preventive medical check-up at the Centre d’Investigations Préventives et Cliniques in Paris (France), will be enrolled in the study, after signing an informed consent. In addition to the general health examination, each subject’s heart rhythm will be recorded during the course of the health check-up (approximately 21/2 h) and an echo-tracking of the right carotid bulb will be performed by trained technicians. A bio bank and DNA bank will be established for further biomarker and genetic analyses. The occurrence of cardiovascular disease including acute coronary syndrome, stroke, peripheral artery disease and sudden death, and of mortality, of the participants will be followed up during 20 years. With an estimated mean annual rate of sudden death of 0.1% and its increasing incidence rate with age, between 250 and 300 sudden deaths are expected. This unique study should provide new insights into the regulation of heart rate and blood pressure and should enable to identify novel heart rate parameters that are associated with sudden death.

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Acknowledgments

Erwan Bozec for the training of the technicians in echotracking. Dr MF Eprinchard, Dr JM Kirzin and all the medical and technical staff of the IPC. Centre de Ressources Biologiques de l’hôpital G Pompidou staff: C de Toma, B Vedie. The Platform for Biological Resources (PRB) of the Hôpital Européen Georges Pompidou (HEGP) for the management of the biobank. The PPS3 is organized under an agreement between INSERM and the IPC Centre, between INSERM and the Centre de Ressources Biologiques de l’Hôpital Europeén Georges Pompidou (HEGP). We thank the Caisse Nationale d’Assurance Maladie des Travailleurs Salariés (CNAM-TS, France) and the Caisse Primaire d’Assurance Maladie de Paris (CPAM-P, France) for helping make this study possible. The PPS3 Study was funded by grants from The National Research Agency (ANR), the Research Foundation for Hypertension (FRHTA), the Research Institute in Public Health (IRESP) and from the Region Ile de France (Domaine d’Intérêt Majeur) in France.

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None declared.

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Authors and Affiliations

  1. Paris Cardiovascular Research Centre, University Paris Descartes, UMR-S970, Paris, France

    Jean-Philippe Empana, Catherine Guibout, Annie Bingham, Pierre Boutouyrie & Xavier Jouven

  2. Centre d’Investigations Préventives et Cliniques, Paris, France

    Kathy Bean, Frédérique Thomas & Bruno Pannier

  3. Assistance Publique des Hôpitaux de Paris (APHP), Paris, France

    Pierre Boutouyrie & Xavier Jouven

Authors
  1. Jean-Philippe Empana
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  2. Kathy Bean
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  3. Catherine Guibout
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  4. Frédérique Thomas
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  6. Bruno Pannier
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  7. Pierre Boutouyrie
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  8. Xavier Jouven
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Correspondence to Jean-Philippe Empana.

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Empana, JP., Bean, K., Guibout, C. et al. Paris Prospective Study III: a study of novel heart rate parameters, baroreflex sensitivity and risk of sudden death. Eur J Epidemiol 26, 887–892 (2011). https://doi.org/10.1007/s10654-011-9618-x

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  • DOI: https://doi.org/10.1007/s10654-011-9618-x

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