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Passive smoking, cytochrome P450 gene polymorphisms and dysmenorrhea

  • GENETIC EPIDEMIOLOGY
  • Published:
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Abstract

Purpose This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYP1A1MspI and CYP1A1HincII. Methods This report includes 1,645 (1,124 no dysmenorrhea, 521 dysmenorrhea) non-smoking and non-drinking newly wedding female workers at Anqing, China between June 1997 and June 2000. Multiple logistic regression models were used to estimate the associations of passive smoking exposure and genetic susceptibility with dysmenorrhea, adjusting for maternal age, BMI, age of menarche, education, vibration exposure, shift work, noise exposure, pregnancy history, perceived stress and physical laboring stress. Results In the passive smoking group, women who have C/C6235 genotype (OR = 1.8, 95% CI = 1.0–3.3) in CYP1A1MspI and Ile/Ile462 genotype (OR = 2.9, 95% CI = 1.1–7.7) in CYP1A1HincII was associated with an increased risk of dysmenorrhea. When stratified by women genotype, the adjusted OR of dysmenorrheal was 1.6 (95% CI = 1.2–2.1) for passive smoking group with Ile/Ile462 genotype, and 1.5 (95% CI = 1.0–2.1) with C/C6235 genotype, compared to non-passive smoking group, respectively. The data further showed that there was a significant combined effect between passive smoking and the CYP1A1 Msp1C/C6235 (OR = 1.5, 95% CI = 1.0–2.1), and HincII Ile/Ile462 (OR = 1.6, 95% CI = 1.2–2.1), respectively. Conclusion CYP1A1 MspI and HincII genotypes modified the association between passive smoking and dysmenorrhea.

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Acknowledgements

The study was supported in part by grant HD32505 from the National Institute of Child Health and Human Development; grants ES8337, ES-00002, ES06198, ES11682, and ES08957 from the National Institute of Environmental Health Sciences; and grants 20-FY98-0701 and 20-FY02-56 from the March of Dimes Birth Defects Foundation, and the special scientific research foundation for doctoral discipline area of the Ministry of Education, P. R. of China. We gratefully acknowledge the assistance and cooperation of the staff of the Anhui Biomedical Institute. We are thankful to all the participants in our study.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing, 100083, China

    Lou Lei, Linan Ye, Hong Liu, Lihua Wang, Yonghua Hu & Dafang Chen

  2. Brigham and Women’s hospital, Harvard Medical School, Boston, MA, USA

    Changzhong Chen

  3. Anhui Biomedical Institute, Anhui Province, China

    Zhian Fang

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  1. Lou Lei
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  3. Hong Liu
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Correspondence to Dafang Chen.

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Lei, L., Ye, L., Liu, H. et al. Passive smoking, cytochrome P450 gene polymorphisms and dysmenorrhea. Eur J Epidemiol 23, 475–481 (2008). https://doi.org/10.1007/s10654-008-9250-6

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  • DOI: https://doi.org/10.1007/s10654-008-9250-6

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