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AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families

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Abstract

Purpose

To investigate the role of alpha2–HS glycoprotein (AHSG) gene on bone mineral density (BMD) variation.

Methods

A total of 665 subjects from 157 Caucasian nuclear families were genotyped at the AHSG NlaIII, SacI sites. The association and linkage between the single SNP markers and haplotypes constructed by two markers in this gene and BMDs at the spine and hip were determined by using quantitative transmission disequilibrium test (QTDT).

Results

Significant within-family associations were obtained for spine BMD at both of studied markers (P = 0.036 and 0.005 at the NlaIII and SacI sites, respectively). Significant (P = 0.008 at the NlaIII locus) (P = 0.004 at the SacI locus) total associations at spine BMD were detected. Haplotype analyses confirmed those within-family and total association.

Conclusions

These data suggest the polymorphisms in the AHSG gene may have effects on BMD variation in Caucasian population.

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Abbreviations

AHSG:

Alpha2-HS glycoprotein

BMD:

Bone mineral density

QTDT:

Quantitative transmission disequilibrium test

OF:

Osteoporotic fractures

LD:

Linkage disequilibrium

PCR:

Polymerase chain reaction

RFLP:

Restriction fragment length polymorphism

DXA:

Dual-energy X-ray absorptiometry

CV:

Coefficient of variability

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Acknowledgments

Investigators of this work were partially supported by grants from NIH (K01 AR02170-01, R01 AR45349-01, R01 GM60402-01A1, P01 DC01813-07) and an LB595 grant from the State of Nebraska. The study was also benefited from grants from National Science Foundation of China, Hunan Normal University, Xi’an Jiaotong University, and the Ministry of Education of China.

Funding Sources: NIH, Health Future Foundation, US Dept. of Energy, State of Nebraska, Creighton University.

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Authors and Affiliations

  1. Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, P.R. China

    Yan-Jun Yang, Yan-Bo Wang, Shu-Feng Lei, De-Ke Jiang, Su-Mei Xiao, Xiang-Ding Chen, Yuan Chen & Hong-Wen Deng

  2. Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE, 68131, USA

    Ji-Rong Long, Hui Shen, Lan-Juan Zhao & Hong-Wen Deng

  3. College of Life Science, Jinzhong University, Jinzhong, Shanxi, 030600, P.R. China

    Yan-Jun Yang

  4. College of Shu Da, Hunan Normal University, Changsha, Hunan, 410081, P.R. China

    Yan-Bo Wang

  5. Department of Orthopedic Surgery, School of Medicine, University of Missouri-Kansas City, 2411 Holmes Street, Kansas City, MO, 64108, USA

    Hong-Wen Deng

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  1. Yan-Jun Yang
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  2. Yan-Bo Wang
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  3. Shu-Feng Lei
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  4. Ji-Rong Long
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  5. Hui Shen
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  6. Lan-Juan Zhao
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  7. De-Ke Jiang
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  8. Su-Mei Xiao
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  9. Xiang-Ding Chen
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  10. Yuan Chen
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  11. Hong-Wen Deng
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Corresponding author

Correspondence to Hong-Wen Deng.

Additional information

Yan-Jun Yang and Yan-Bo Wang contributed equally to this article.

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Yang, YJ., Wang, YB., Lei, SF. et al. AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families. Eur J Epidemiol 22, 527–532 (2007). https://doi.org/10.1007/s10654-007-9140-3

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  • DOI: https://doi.org/10.1007/s10654-007-9140-3

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