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Pre-Analytic Considerations for the Proper Assessment of Hormones of the Hypothalamic-Pituitary Axis in Epidemiological Research

  • Endocrine Epidemiology
  • Published:
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Abstract

There is growing epidemiological interest in hormones as predictors of chronic diseases. The correct handling and analysis of hormones can be cumbersome, and great care must be taken in these processes in order to gain the most information possible. Given differences in sampling, processing, and stability of the various hormonal assays, we sought to provide a comprehensive review to aid future epidemiological research. We have coupled a thorough literature search with our own analytical experience to outline common laboratory problems one must consider in analyzing the hormones of the hypothalamic-pituitary axis. In addition, we describe the benefits and limitations of using alternative media – including urine, saliva, and blood spots on filter paper – to measure endocrine hormones in epidemiological studies.

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Abbreviations

ACTH:

adrenocorticotropin hormone

GH:

growth hormone

ICMA:

immunochemiluminometric assay

IGF-1:

insulin-like growth factor

IMA:

immunoassay

IRMA:

immunoradiometric assay

NA:

no data available

RIA:

radioimmunoassay

TSH:

thyroid stimulating hormone

T4:

thyroxine

T3:

triiodothyronine

References

  1. E Barrett-Connor D Goodman-Gruen (1995) ArticleTitleProspective study of endogenous sex hormones and fatal cardiovascular disease in postmenopausal women Br Med J 311 1193–1196 Occurrence Handle1:STN:280:BymD28bgt1E%3D

    CAS  Google Scholar 

  2. D Goodman-Gruen E Barrett-Connor (2000) ArticleTitleSex differences in the association of endogenous sex hormone levels and glucose tolerance status in older men and women Diabetes Care 23 912–918 Occurrence Handle1:CAS:528:DC%2BD3cXnvV2is78%3D Occurrence Handle10895840

    CAS  PubMed  Google Scholar 

  3. SM Haffner PA Newcomb PM Marcus BE Klein R Klein (1995) ArticleTitleRelation of sex hormones and dehydroepiandrosterone sulfate (DHEA-SO4) to cardiovascular risk factors in postmenopausal women Am J Epidemiol 142 925–934 Occurrence Handle1:STN:280:BymD2c7pt1M%3D Occurrence Handle7572973

    CAS  PubMed  Google Scholar 

  4. SM Gapstur PH Gann P Kopp L Colangelo C Longcope K Liu (2002) ArticleTitleSerum androgen concentrations in young men: a longitudinal analysis of associations with age, obesity, and race. The CARDIA male hormone study Cancer Epidemiol Biomarkers Prev 11 1041–1047 Occurrence Handle1:CAS:528:DC%2BD38Xos1ekur0%3D Occurrence Handle12376505

    CAS  PubMed  Google Scholar 

  5. SR Srinivasan GS Sundaram GD Williamson LS Webber GS Berenson (1985) ArticleTitleSerum lipoproteins and endogenous sex hormones in early life: observations in children with different lipoprotein profiles Metabolism 34 861–867 Occurrence Handle10.1016/0026-0495(85)90111-8 Occurrence Handle1:CAS:528:DyaL2MXkvFyrurY%3D Occurrence Handle3162076

    Article  CAS  PubMed  Google Scholar 

  6. SR Srinivasan DS Freedman GS Sundaram LS Webber GS Berenson (1986) ArticleTitleRacial (black–white) comparisons of the relationship of levels of endogenous sex hormones to serum lipoproteins during male adolescence: the Bogalusa Heart Study Circulation 74 1226–1234 Occurrence Handle1:STN:280:BiiD2M3gsFY%3D Occurrence Handle2946492

    CAS  PubMed  Google Scholar 

  7. SH Golden A Maguire J Ding et al. (2002) ArticleTitleEndogenous postmenopausal hormones and carotid atherosclerosis: a case-control study of the atherosclerosis risk in communities cohort Am J Epidemiol 155 437–445 Occurrence Handle10.1093/aje/155.5.437 Occurrence Handle11867355

    Article  PubMed  Google Scholar 

  8. SM Haffner SE Moss BE Klein R Klein (1996) ArticleTitleSex hormones and DHEA-SO4 in relation to ischemic heart disease mortality in diabetic subjects. The Wisconsin Epidemiologic Study of Diabetic Retinopathy Diabetes Care 19 1045–1050 Occurrence Handle1:STN:280:ByiD2c7islM%3D Occurrence Handle8886548

    CAS  PubMed  Google Scholar 

  9. JF Price AJ Lee FG Fowkes (1997) ArticleTitleSteroid sex hormones and peripheral arterial disease in the Edinburgh Artery Study Steroids 62 789–794 Occurrence Handle10.1016/S0039-128X(97)00103-7 Occurrence Handle1:CAS:528:DyaK2sXotVGms7c%3D Occurrence Handle9434345

    Article  CAS  PubMed  Google Scholar 

  10. GP Bernini M Sgro A Moretti et al. (1999) ArticleTitleEndogenous androgens and carotid intimal-medial thickness in women J Clin Endocrinol Metab 84 2008–2012 Occurrence Handle10.1210/jc.84.6.2008 Occurrence Handle1:CAS:528:DyaK1MXjs1Ohsrc%3D Occurrence Handle10372702

    Article  CAS  PubMed  Google Scholar 

  11. S Kumagai Y Kai H Sasaki (2001) ArticleTitleRelationship between insulin resistance, sex hormones and sex hormone-binding globulin in the serum lipid and lipoprotein profiles of Japanese postmenopausal women J Atheroscler Thromb 8 14–20 Occurrence Handle1:CAS:528:DC%2BD3MXmsVyls7k%3D Occurrence Handle11686310

    CAS  PubMed  Google Scholar 

  12. CS Mantzoros EI Georgiadis R Young et al. (1995) ArticleTitleRelative androgenicity, blood pressure levels, and cardiovascular risk factors in young healthy women Am J Hypertens 8 606–614 Occurrence Handle10.1016/0895-7061(95)00051-P Occurrence Handle1:STN:280:ByqA1M7itFI%3D Occurrence Handle7662245

    Article  CAS  PubMed  Google Scholar 

  13. GB Phillips BH Pinkernell TY Jing (1997) ArticleTitleRelationship between serum sex hormones and coronary artery disease in postmenopausal women Arterioscler Thromb Vasc Biol 17 695–701 Occurrence Handle1:STN:280:ByiB283kvFw%3D Occurrence Handle9108782

    CAS  PubMed  Google Scholar 

  14. JC Seidell M Cigolini J Charzewska et al. (1990) ArticleTitleAndrogenicity in relation to body fat distribution and metabolism in 38-year-old women – the European Fat Distribution Study J Clin Epidemiol 43 21–34 Occurrence Handle10.1016/0895-4356(90)90052-Q Occurrence Handle1:STN:280:By%2BB3czpsFQ%3D Occurrence Handle2181077

    Article  CAS  PubMed  Google Scholar 

  15. JT Soler AR Folsom SA Kaye RJ Prineas (1989) ArticleTitleAssociations of abdominal adiposity, fasting insulin, sex hormone binding globulin, and estrone with lipids and lipoproteins in post-menopausal women Atherosclerosis 79 21–27 Occurrence Handle10.1016/0021-9150(89)90029-4 Occurrence Handle1:CAS:528:DyaL1MXlvFahtr8%3D Occurrence Handle2803343

    Article  CAS  PubMed  Google Scholar 

  16. JA Cauley JP Gutai LH Kuller JG Powell (1991) ArticleTitleReliability and interrelations among serum sex hormones in postmenopausal women Am J Epidemiol 133 50–57 Occurrence Handle1:STN:280:By6D28fntlE%3D Occurrence Handle1983898

    CAS  PubMed  Google Scholar 

  17. WT Moore RC Eastman (1990) Diagnostic Endocrinology B.C. Decker Toronto

    Google Scholar 

  18. CA Burtis ER Ashwood (1999) Tietz Textbook of Clinical Chemistry W.B. Saunders Co Philadelphia, PA

    Google Scholar 

  19. MB Ranke U Feldt-Rasmussen P Bang et al. (2001) ArticleTitleHow should insulin-like growth factor I be measured? A consensus statement Horm Res 55 IssueIDSuppl 2 106–109 Occurrence Handle1:CAS:528:DC%2BD3MXnvVCktLc%3D Occurrence Handle11684887

    CAS  PubMed  Google Scholar 

  20. MB Ranke H Orskov AF Bristow J Seth G Baumann (1999) ArticleTitleConsensus on how to measure growth hormone in serum Horm Res 51 IssueIDSuppl 1 27–29 Occurrence Handle1:CAS:528:DyaK1MXkt1aktro%3D Occurrence Handle10393488

    CAS  PubMed  Google Scholar 

  21. A White H Smith M Hoadley SH Dobson JG Ratcliffe (1987) ArticleTitleClinical evaluation of a two-site immunoradiometric assay for adrenocorticotrophin in unextracted human plasma using monoclonal antibodies Clin Endocrinol (Oxf) 26 41–51 Occurrence Handle1:CAS:528:DyaL2sXps1ejug%3D%3D

    CAS  Google Scholar 

  22. CA Spencer M Takeuchi M Kazarosyan (1996) ArticleTitleCurrent status and performance goals for serum thyrotropin (TSH) assays Clin Chem 42 140–145 Occurrence Handle1:CAS:528:DyaK28XntValsQ%3D%3D Occurrence Handle8565217

    CAS  PubMed  Google Scholar 

  23. LM Demers CA Spencer (2003) ArticleTitleLaboratory medicine practice guidelines: laboratory support for the diagnosis and monitoring of thyroid disease Clin Endocrinol (Oxf) 58 138–140 Occurrence Handle10.1046/j.1365-2265.2003.01681.x Occurrence Handle1:STN:280:DC%2BD3s%2FntFWmtQ%3D%3D

    Article  CAS  Google Scholar 

  24. RE Chestnut V Quarmby (2002) ArticleTitleEvaluation of total IGF-I assay methods using samples from Type I and Type II diabetic patients J Immunol Methods 259 11–24 Occurrence Handle10.1016/S0022-1759(01)00478-1 Occurrence Handle1:CAS:528:DC%2BD3MXos1agurs%3D Occurrence Handle11730837

    Article  CAS  PubMed  Google Scholar 

  25. WS Dhillo WM Kong CW Roux ParticleLe et al. (2002) ArticleTitleCortisol-binding globulin is important in the interpretation of dynamic tests of the hypothalamic–pituitary–adrenal axis Eur J Endocrinol 146 231–235 Occurrence Handle10.1530/eje.0.1460231 Occurrence Handle1:CAS:528:DC%2BD38XhvVenu7c%3D Occurrence Handle11834433

    Article  CAS  PubMed  Google Scholar 

  26. CA Roelen HP Koppeschaar WR Vries Particlede et al. (1997) ArticleTitleVisceral adipose tissue is associated with circulating high affinity growth hormone-binding protein J Clin Endocrinol Metab 82 760–764 Occurrence Handle10.1210/jc.82.3.760 Occurrence Handle1:CAS:528:DyaK2sXhsl2jsbc%3D Occurrence Handle9062478

    Article  CAS  PubMed  Google Scholar 

  27. TK Wong AE Pekary GS Hoo ME Bradley JM Hershman (1992) ArticleTitleComparison of methods for measuring free thyroxin in nonthyroidal illness Clin Chem 38 720–724 Occurrence Handle1:CAS:528:DyaK38XlvVGjs7s%3D Occurrence Handle1582025

    CAS  PubMed  Google Scholar 

  28. JW Meakin (1960) ArticleTitleCatabolism of ACTH: the stability of ACTH in blood, plasma, serum and saline Endocrinology 66 59–62 Occurrence Handle1:CAS:528:DyaF3cXpvVCmsQ%3D%3D Occurrence Handle13848642

    CAS  PubMed  Google Scholar 

  29. ST Wang S Pizzolato HP Demshar (1998) ArticleTitleDiagnostic effectiveness of TSH screening and of T4 with secondary TSH screening for newborn congenital hypothyroidism Clin Chim Acta 274 151–158 Occurrence Handle10.1016/S0009-8981(98)00057-6 Occurrence Handle1:CAS:528:DyaK1cXjt1Cmsbk%3D Occurrence Handle9694583

    Article  CAS  PubMed  Google Scholar 

  30. T Laursen J Moller JO Jorgensen H Orskov JS Christiansen (1996) ArticleTitleBioavailability and bioactivity of intravenous vs subcutaneous infusion of growth hormone in GH-deficient patients Clin Endocrinol (Oxf) 45 333–339 Occurrence Handle10.1046/j.1365-2265.1996.00814.x Occurrence Handle1:CAS:528:DyaK28XmsFCls7Y%3D

    Article  CAS  Google Scholar 

  31. RM Reynolds HE Bendall CB Whorwood PJ Wood BR Walker DI Phillips (1998) ArticleTitleReproducibility of the low dose dexamethasone suppression test: Comparison between direct plasma and salivary cortisol assays Clin Endocrinol (Oxf) 49 307–310 Occurrence Handle10.1046/j.1365-2265.1998.00549.x Occurrence Handle1:CAS:528:DyaK1cXmvFGhsL0%3D

    Article  CAS  Google Scholar 

  32. D Fisher P Ladenson (1996) The Corning Endocrine Manuel Corning Nichols Institute Capistrano CA

    Google Scholar 

  33. J Wilson (1998) William Textbook of Endocrinology W.B. Saunders Co Philadelphia

    Google Scholar 

  34. D Milani JD Carmichael J Welkowitz S Ferris RE Reitz A Danoff DL Kleinberg (2004) ArticleTitleVariability and reliability of single serum IGF-1 measurements: impact on determining predictability of risk ratios in disease development J Clin Endocrinol Metab 89 2271–2274 Occurrence Handle1:CAS:528:DC%2BD2cXjvFyrtL0%3D Occurrence Handle15126552

    CAS  PubMed  Google Scholar 

  35. JH Mendelson MB Sholar N Goletiani AJ Siegel NK Mello (2005) ArticleTitleEffects of low- and high-nicotine cigarette smokin on mood states and the HPA axis in men Neuropsychopharmacology 30 1751–1763 Occurrence Handle10.1038/sj.npp.1300753 Occurrence Handle1:CAS:528:DC%2BD2MXotFegu7w%3D Occurrence Handle15870834

    Article  CAS  PubMed  Google Scholar 

  36. D Szostak-Wegierek P Bjorntorp P Marin G Lindstedt B Andersson (1996) ArticleTitleInfluence of smoking on hormone secretion in obese and lean female smokers Obes Res 4 321–328 Occurrence Handle1:CAS:528:DyaK28XkvFSgsbs%3D Occurrence Handle8822756

    CAS  PubMed  Google Scholar 

  37. A Luger PA Deuster SB Kyle et al. (1987) ArticleTitleAcute hypothalamic–pituitary–adrenal responses to the stress of treadmill exercise. Physiologic adaptations to physical training N Engl J Med 316 1309–1315 Occurrence Handle1:CAS:528:DyaL2sXkvFSgtrs%3D Occurrence Handle3033504

    CAS  PubMed  Google Scholar 

  38. A Singh JS Petrides PW Gold GP Chrousos PA Deuster (1999) ArticleTitleDifferential hypothalamic–pituitary–adrenal axis reactivity to psychological and physical stress J Clin Endocrinol Metab 84 1944–839 Occurrence Handle10.1210/jc.84.6.1944 Occurrence Handle1:CAS:528:DyaK1MXjs1Oiu7o%3D Occurrence Handle10372691

    Article  CAS  PubMed  Google Scholar 

  39. SD Richter TH Schurmeyer M Schedlowski A Hadicke U Tewes RE Schmidt TO Wagner (1996) ArticleTitleTime kinetics of the endocrine response to acute psychological stress J Clin Endocrinol Metab 81 1956–1960 Occurrence Handle10.1210/jc.81.5.1956 Occurrence Handle1:CAS:528:DyaK28XjtVShtLg%3D Occurrence Handle8626864

    Article  CAS  PubMed  Google Scholar 

  40. B McIver CA Gorman (1997) ArticleTitleEuthyroid sick syndrome: An overview Thyroid 7 125–132 Occurrence Handle1:STN:280:ByiB2c7itV0%3D Occurrence Handle9086580

    CAS  PubMed  Google Scholar 

  41. MI Surks R Sievert (1995) ArticleTitleDrugs and thyroid function N Engl J Med 333 1688–1694 Occurrence Handle10.1056/NEJM199512213332507 Occurrence Handle1:CAS:528:DyaK28XkvFyqug%3D%3D Occurrence Handle7477223

    Article  CAS  PubMed  Google Scholar 

  42. MF Prummel WM Wiersinga H Oosting E Endert (1996) ArticleTitleThe effect of long-term prednisone treatment on growth hormone and insulin-like growth factor-1 J Endocrinol Invest 19 620–623 Occurrence Handle1:CAS:528:DyaK28XnsV2qt74%3D Occurrence Handle8957747

    CAS  PubMed  Google Scholar 

  43. J Khosravi A Diamandi Um Bodani N Khaja RG Krishna (2005) ArticleTitlePitfalls of immunoassay and sample for IGF-1: comparison of different assay methodologies using various fresh and stored serum samples Clin Biochem 38 659–666 Occurrence Handle1:CAS:528:DC%2BD2MXmtFGisrs%3D Occurrence Handle15885685

    CAS  PubMed  Google Scholar 

  44. JH Livesey SC Hodgkinson HR Roud RA Donald (1980) ArticleTitleEffect of time, temperature and freezing on the stability of immunoreactive LH, FSH, TSH, growth hormone, prolactin and insulin in plasma Clin Biochem 13 151–155 Occurrence Handle1:CAS:528:DyaL3cXlvVagtbk%3D Occurrence Handle6778631

    CAS  PubMed  Google Scholar 

  45. NP Kubasik M Ricotta T Hunter HE Sine (1982) ArticleTitleEffect of duration and temperature of storage on serum analyte stability: examination of 14 selected radioimmunoassay procedures Clin Chem 28 164–165 Occurrence Handle1:CAS:528:DyaL38XpslOquw%3D%3D Occurrence Handle7034999

    CAS  PubMed  Google Scholar 

  46. MJ Evans JH Livesey MJ Ellis TG Yandle (2001) ArticleTitleEffect of anticoagulants and storage temperatures on stability of plasma and serum hormones Clin Biochem 34 107–112 Occurrence Handle1:CAS:528:DC%2BD3MXjs1Ogtbs%3D Occurrence Handle11311219

    CAS  PubMed  Google Scholar 

  47. G Kertesz B Bourcier H Cailla F Jean (1998) ArticleTitleImmunoradiometric assay of succinylated corticotropin: an improved method for quantification of ACTH Clin Chem 44 78–85 Occurrence Handle1:CAS:528:DyaK1cXltFWnsg%3D%3D Occurrence Handle9550562

    CAS  PubMed  Google Scholar 

  48. T Kashiwai K Ichihara H Tamaki et al. (1991) ArticleTitleThe stability of immunological and biological activity of human thyrotropin in buffer: its temperature-dependent dissociation into subunits during freezing Scand J Clin Lab Invest 51 417–423 Occurrence Handle1:CAS:528:DyaK3MXmt1Cjtrg%3D Occurrence Handle1947726

    CAS  PubMed  Google Scholar 

  49. HA Oomen AJ Schipperijn HA Drexhage (1996) ArticleTitleThe prevalence of affective disorder and in particular of a rapid cycling of bipolar disorder in patients with abnormal thyroid function tests Clin Endocrinol (Oxf) 45 215–223 Occurrence Handle10.1046/j.1365-2265.1996.d01-1558.x Occurrence Handle1:STN:280:ByiD3srotVM%3D

    Article  CAS  Google Scholar 

  50. M Opravil M Pechere R Speich et al. (1997) ArticleTitleHIV-associated primary pulmonary hypertension. A case control study. Swiss HIV Cohort Study Am J Respir Crit Care Med 155 990–995 Occurrence Handle1:STN:280:ByiB3srptVI%3D Occurrence Handle9117037

    CAS  PubMed  Google Scholar 

  51. A Juul T Scheike M Davidsen J Gyllenborg T Jorgensen (2002) ArticleTitleLow serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case–control study Circulation 106 939–944 Occurrence Handle10.1161/01.CIR.0000027563.44593.CC Occurrence Handle1:CAS:528:DC%2BD38XntlSqs78%3D Occurrence Handle12186797

    Article  CAS  PubMed  Google Scholar 

  52. R Palmqvist G Hallmans S Rinaldi et al. (2002) ArticleTitlePlasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden Gut 50 642–646 Occurrence Handle10.1136/gut.50.5.642 Occurrence Handle1:STN:280:DC%2BD383ktFKrsg%3D%3D Occurrence Handle11950809

    Article  CAS  PubMed  Google Scholar 

  53. J Ma MN Pollak E Giovannucci et al. (1999) ArticleTitleProspective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3 J Natl Cancer Inst 91 620–625 Occurrence Handle1:CAS:528:DyaK1MXislKgs70%3D Occurrence Handle10203281

    CAS  PubMed  Google Scholar 

  54. AM Nomura GN Stemmermann J Lee MN Pollak (2003) ArticleTitleSerum insulin-like growth factor I and subsequent risk of colorectal cancer among Japanese–American men Am J Epidemiol 158 424–431 Occurrence Handle10.1093/aje/kwg176 Occurrence Handle12936897

    Article  PubMed  Google Scholar 

  55. JM Chan MJ Stampfer E Giovannucci et al. (1998) ArticleTitlePlasma insulin-like growth factor-I and prostate cancer risk: A prospective study Science 279 563–566 Occurrence Handle10.1126/science.279.5350.563 Occurrence Handle1:CAS:528:DyaK1cXotVOqsg%3D%3D Occurrence Handle9438850

    Article  CAS  PubMed  Google Scholar 

  56. K Woodson JA Tangrea M Pollak et al. (2003) ArticleTitleSerum insulin-like growth factor I: tumor marker or etiologic factor? A prospective study of prostate cancer among Finnish men Cancer Res 63 3991–3994 Occurrence Handle1:CAS:528:DC%2BD3sXlsFOjurg%3D Occurrence Handle12873996

    CAS  PubMed  Google Scholar 

  57. SE Hankinson WC Willett GA Colditz et al. (1998) ArticleTitleCirculating concentrations of insulin-like growth factor-I and risk of breast cancer Lancet 351 1393–1396 Occurrence Handle10.1016/S0140-6736(97)10384-1 Occurrence Handle1:STN:280:DyaK1c3lsVansw%3D%3D Occurrence Handle9593409

    Article  CAS  PubMed  Google Scholar 

  58. MR Spitz MJ Barnett GE Goodman MD Thornquist X Wu M Pollak (2002) ArticleTitleSerum insulin-like growth factor (IGF) and IGF-binding protein levels and␣risk of lung cancer: a case-control study nested in the beta-Carotene and Retinol Efficacy Trial Cohort Cancer Epidemiol Biomarkers Prev 11 1413–1418 Occurrence Handle1:CAS:528:DC%2BD38XpsVyks7w%3D Occurrence Handle12433720

    CAS  PubMed  Google Scholar 

  59. HK Kley R Schlaghecke HL Kruskemper (1985) ArticleTitleStability of steroids in plasma over a 10-year period J Clin Chem Clin Biochem 23 875–878 Occurrence Handle1:CAS:528:DyaL28Xht1egtLY%3D Occurrence Handle3831227

    CAS  PubMed  Google Scholar 

  60. CM Worthman JF Stallings (1997) ArticleTitleHormone measures in finger-prick blood spot samples: new field methods for reproductive endocrinology Am J Phys Anthropol 104 1–21 Occurrence Handle10.1002/(SICI)1096-8644(199709)104:1<1::AID-AJPA1>3.0.CO;2-V Occurrence Handle1:STN:280:ByiH2s3kvFU%3D Occurrence Handle9331450

    Article  CAS  PubMed  Google Scholar 

  61. PP Bourdoux HV Thi ParticleVan PA Courtois AM Ermans (1991) ArticleTitleSuperiority of thyrotropin to thyroxine as a tool in the screening for congenital hypothyroidism by the filter paper spot technique Clin Chim Acta 195 97–105 Occurrence Handle10.1016/0009-8981(91)90129-Z Occurrence Handle1:CAS:528:DyaK3MXhtFGnurg%3D Occurrence Handle2029777

    Article  CAS  PubMed  Google Scholar 

  62. KV Waite GF Maberly CJ Eastman (1987) ArticleTitleStorage conditions and stability of thyrotropin and thyroid hormones on filter paper Clin Chem 33 853–855 Occurrence Handle1:CAS:528:DyaL2sXktlegsLo%3D Occurrence Handle3594835

    CAS  PubMed  Google Scholar 

  63. A Diamandi MJ Khosravi J Mistry V Martinez J Guevara-Aguirre (1998) ArticleTitleFilter paper blood spot assay of human insulin-like growth factor I (IGF-I) and IGF-binding protein-3 and preliminary application in the evaluation of growth hormone status J Clin Endocrinol Metab 83 2296–2301 Occurrence Handle10.1210/jc.83.7.2296 Occurrence Handle1:CAS:528:DyaK1cXksVSjtbc%3D Occurrence Handle9661598

    Article  CAS  PubMed  Google Scholar 

  64. JS Jones (2001) ArticleTitleInsulin-like growth factor I measurement on filter paper blood spots Horm Res 55 IssueIDSuppl 2 80–83 Occurrence Handle1:CAS:528:DC%2BD3MXnvVCktLw%3D Occurrence Handle11684883

    CAS  PubMed  Google Scholar 

  65. ML Mitchell RJ Hermos (1998) ArticleTitleCortisol in dried blood screening specimens from newborns with raised 17-hydroxyprogesterone and congenital adrenal hyperplasia Clin Endocrinol (Oxf) 48 757–760 Occurrence Handle10.1046/j.1365-2265.1998.00430.x Occurrence Handle1:CAS:528:DyaK1cXksFagu70%3D

    Article  CAS  Google Scholar 

  66. Z Kraiem L Kahana V Elias S Ghersin M Sheinfeld (1980) ArticleTitleRadioimmunoassay of cortisol in blood collected on filter paper Clin Chem 26 1916–1917 Occurrence Handle1:CAS:528:DyaL3MXnvFOisg%3D%3D Occurrence Handle7438446

    CAS  PubMed  Google Scholar 

  67. K Yoshida T Sakurada K Kaise et al. (1988) ArticleTitleMeasurement of thyroid stimulating hormone (TSH) in human urine Endocrinol Jpn 35 733–739 Occurrence Handle1:CAS:528:DyaL1MXlsFChsQ%3D%3D Occurrence Handle2464492

    CAS  PubMed  Google Scholar 

  68. BW Moss JW Jordan A McAllister (1979) ArticleTitleThe measurement of thyroxine in urine using a competitive protein binding technique Clin Chim Acta 92 387–398 Occurrence Handle10.1016/0009-8981(79)90218-3 Occurrence Handle1:CAS:528:DyaE1MXhvValurw%3D Occurrence Handle571313

    Article  CAS  PubMed  Google Scholar 

  69. RA Shakespear CW Burke (1976) ArticleTitleTriiodothyronine and thyroxine in urine. I. Measurement and application J Clin Endocrinol Metab 42 494–503 Occurrence Handle1:CAS:528:DyaE28Xhs1altLg%3D Occurrence Handle1254690

    CAS  PubMed  Google Scholar 

  70. A Johansson R Andrew H Forsberg K Cederquist BR Walker T Olsson (2001) ArticleTitleGlucocorticoid metabolism and adrenocortical reactivity to ACTH in myotonic dystrophy J Clin Endocrinol Metab 86 4276–4283 Occurrence Handle10.1210/jc.86.9.4276 Occurrence Handle1:CAS:528:DC%2BD3MXmvFCkurg%3D Occurrence Handle11549662

    Article  CAS  PubMed  Google Scholar 

  71. RM Reynolds BR Walker HE Syddall et al. (2001) ArticleTitleAltered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors J Clin Endocrinol Metab 86 245–250 Occurrence Handle1:CAS:528:DC%2BD3MXhtVGnsLY%3D Occurrence Handle11232008

    CAS  PubMed  Google Scholar 

  72. AJ Weissberger KY Ho MC Stuart (1989) ArticleTitleQuantification of urinary growth hormone (GH) excretion by centrifugal ultrafiltration and radioimmunoassay: Appraisal of the relationship between 24 h urinary GH and mean 24 h serum GH levels in normal and abnormal states of GH secretion Clin Endocrinol (Oxf) 30 687–698 Occurrence Handle1:CAS:528:DyaL1MXkslWju7o%3D

    CAS  Google Scholar 

  73. P Hourd R Edwards (1994) ArticleTitleCurrent methods for the measurement of growth hormone in urine Clin Endocrinol (Oxf) 40 155–170 Occurrence Handle1:CAS:528:DyaK2cXjtFGqsrc%3D

    CAS  Google Scholar 

  74. AS Bates AJ Evans P Jones RN Clayton (1995) ArticleTitleAssessment of GH status in acromegaly using serum growth hormone, serum insulin-like growth factor-1 and urinary growth hormone excretion Clin Endocrinol (Oxf) 42 417–423 Occurrence Handle1:STN:280:ByqB28bjs1I%3D

    CAS  Google Scholar 

  75. J Leger C Reverchon D Porquet M Noel P Czernichow (1995) ArticleTitleThe wide variation in urinary excretion of human growth hormone in normal growing and growth hormone-deficient children limits its clinical usefulness Horm Res 44 57–63 Occurrence Handle1:CAS:528:DyaK2MXnvVegsr8%3D Occurrence Handle7590633

    CAS  PubMed  Google Scholar 

  76. MS Gill AA Toogood PA O’Neill MO Thorner SM Shalet PE Clayton (1998) ArticleTitleUrinary growth hormone (GH), insulin-like growth factor I (IGF-1), and IGF-binding protein-3 measurements in the diagnosis of adult GH deficiency J Clin Endocrinol Metab 83 2562–2565 Occurrence Handle10.1210/jc.83.7.2562 Occurrence Handle1:CAS:528:DyaK1cXksVSisLo%3D Occurrence Handle9661643

    Article  CAS  PubMed  Google Scholar 

  77. V Popii G Baumann (2004) ArticleTitleLaboratory measurement of growth hormone Clin Chim Acta 350 1–16 Occurrence Handle10.1016/j.cccn.2004.06.007 Occurrence Handle1:CAS:528:DC%2BD2cXpsVKnu7w%3D Occurrence Handle15530455

    Article  CAS  PubMed  Google Scholar 

  78. N Hizuka K Takano I Tanaka et al. (1987) ArticleTitleDemonstration of insulin-like growth factor I in human urine J Clin Endocrinol Metab 64 1309–1312 Occurrence Handle1:CAS:528:DyaL2sXktFynu78%3D Occurrence Handle3571431

    CAS  PubMed  Google Scholar 

  79. EF Palo ParticleDe R Gatti F Lancerin et al. (2002) ArticleTitleUrinary insulin-like growth factor I in athletes, before and after physical exercise, and in sedentary subjects Clin Chim Acta 322 51–57 Occurrence Handle12104081

    PubMed  Google Scholar 

  80. M Fujihara J Uemasu H Kawasaki (1996) ArticleTitleSerum and urinary levels of insulin-like growth factor I in patients with chronic renal disease and diabetes mellitus: its clinical implication Clin Nephrol 45 372–378 Occurrence Handle1:STN:280:BymA1crjslQ%3D Occurrence Handle8793228

    CAS  PubMed  Google Scholar 

  81. Y Hasegawa P Cohen P Yorgin RG Rosenfeld (1992) ArticleTitleCharacterization of urinary insulin-like growth factor binding proteins J Clin Endocrinol Metab 74 830–835 Occurrence Handle10.1210/jc.74.4.830 Occurrence Handle1:STN:280:By2C1MzksFc%3D Occurrence Handle1372323

    Article  CAS  PubMed  Google Scholar 

  82. CK Baum MJ Davison J Landon (1974) ArticleTitleProceedings: Urinary free cortisol excretion by normal subjects J Endocrinol 63 47P–48P Occurrence Handle1:STN:280:CSqD2sfjvFA%3D Occurrence Handle4443713

    CAS  PubMed  Google Scholar 

  83. K Miki A Sudo (1998) ArticleTitleEffect of urine pH, storage time, and temperature on stability of catecholamines, cortisol, and creatinine Clin Chem 44 1759–1762 Occurrence Handle1:CAS:528:DyaK1cXltleks70%3D Occurrence Handle9702972

    CAS  PubMed  Google Scholar 

  84. E Aardal-Eriksson BE Karlberg AC Holm (1998) ArticleTitleSalivary cortisol – an alternative to serum cortisol determinations in dynamic function tests Clin Chem Lab Med 36 215–222 Occurrence Handle10.1515/CCLM.1998.037 Occurrence Handle1:CAS:528:DyaK1cXkslCgtL0%3D Occurrence Handle9638346

    Article  CAS  PubMed  Google Scholar 

  85. MH Laudat S Cerdas C Fournier D Guiban B Guilhaume JP Luton (1988) ArticleTitleSalivary cortisol measurement: a practical approach to assess pituitary-adrenal function J Clin Endocrinol Metab 66 343–348 Occurrence Handle1:STN:280:BieC3Mrot1I%3D Occurrence Handle2828410

    CAS  PubMed  Google Scholar 

  86. P Bolufer A Gandia A Rodriguez P Antonio (1989) ArticleTitleSalivary corticosteroids in the study of adrenal function Clin Chim Acta 183 217–225 Occurrence Handle10.1016/0009-8981(89)90337-9 Occurrence Handle1:CAS:528:DyaL1MXlsVKqu7s%3D Occurrence Handle2791306

    Article  CAS  PubMed  Google Scholar 

  87. JD Reid RC Intrieri EJ Susman JL Beard (1992) ArticleTitleThe relationship of serum and salivary cortisol in a sample of healthy elderly J Gerontol 47 P176–P179 Occurrence Handle1:STN:280:By2B2c3ns1w%3D Occurrence Handle1573202

    CAS  PubMed  Google Scholar 

  88. C Kirschbaum DH Hellhammer (1994) ArticleTitleSalivary cortisol in psychoneuroendocrine research: recent developments and applications Psychoneuroendocrinology 19 313–333 Occurrence Handle10.1016/0306-4530(94)90013-2 Occurrence Handle1:CAS:528:DyaK2cXkt1Ojs78%3D Occurrence Handle8047637

    Article  CAS  PubMed  Google Scholar 

  89. YM Chen NM Cintron PA Whitson (1992) ArticleTitleLong-term storage of salivary cortisol samples at room temperature Clin Chem 38 304 Occurrence Handle1:STN:280:By2C2svjtF0%3D Occurrence Handle1541015

    CAS  PubMed  Google Scholar 

  90. AH Garde AM Hansen (2005) ArticleTitleLong-term stability of salivary cortisol Scand J Clin Lab Invest 65 433–436 Occurrence Handle1:CAS:528:DC%2BD2MXpvVShtL4%3D Occurrence Handle16081365

    CAS  PubMed  Google Scholar 

  91. RF Vining RA McGinley (1987) ArticleTitleThe measurement of hormones in saliva: possibilities and pitfalls J Steroid Biochem 27 81–94 Occurrence Handle10.1016/0022-4731(87)90297-4 Occurrence Handle1:CAS:528:DyaL1cXmvFSmug%3D%3D Occurrence Handle3320544

    Article  CAS  PubMed  Google Scholar 

  92. Z Putz A Vanuga J Veleminsky (1985) ArticleTitleRadioimmunoassay of thyroxine in saliva Exp Clin Endocrinol 85 199–203 Occurrence Handle1:STN:280:BiqB2MjovVU%3D Occurrence Handle3926523

    CAS  PubMed  Google Scholar 

  93. PJ Rantonen I Penttila JH Meurman K Savolainen S Narvanen T Helenius (2000) ArticleTitleGrowth hormone and cortisol in serum and saliva Acta Odontol Scand 58 299–303 Occurrence Handle1:CAS:528:DC%2BD3MXjsFyjtQ%3D%3D Occurrence Handle11196407

    CAS  PubMed  Google Scholar 

  94. DC Costigan HJ Guyda BI Posner (1988) ArticleTitleFree insulin-like growth factor I (IGF-I) and IGF-II in human saliva J Clin Endocrinol Metab 66 1014–1018 Occurrence Handle1:CAS:528:DyaL1cXktVWnsL4%3D Occurrence Handle3360895

    CAS  PubMed  Google Scholar 

  95. S Halimi D Tepavcevic D Suchanek Z Giljevic V Palvsic M Korsic (1994) ArticleTitleMeasurement of salivary insulin-like growth factor-I in acromegaly: comparison with serum insulin-like growth factor-I and growth hormone concentrations Eur J Clin Chem Clin Biochem 32 705–707 Occurrence Handle1:CAS:528:DyaK2MXitVCqs7c%3D Occurrence Handle7865627

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, Johns Hopkins University, Baltimore, MD, USA

    Rachel L. Derr & Sherita Hill Golden

  2. Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Scott J. Cameron

  3. Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA

    Sherita Hill Golden

  4. Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 2024 E. Monument Street, Suite 2-600, Baltimore, MD, 21205, USA

    Sherita Hill Golden

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  1. Rachel L. Derr
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  2. Scott J. Cameron
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  3. Sherita Hill Golden
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Derr, R.L., Cameron, S.J. & Golden, S.H. Pre-Analytic Considerations for the Proper Assessment of Hormones of the Hypothalamic-Pituitary Axis in Epidemiological Research. Eur J Epidemiol 21, 217–226 (2006). https://doi.org/10.1007/s10654-006-0011-0

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