Abstract
The objective of this study was to evaluate the association between number of missing teeth and all cause, cardiovascular, and cancer mortality as well as morbidity and to explore whether socio-economic factors mediate this association. An ongoing prospective cohort study of 1462 Swedish women included a dental survey in 1968/69 with follow-up until 1992/93. The dental examination included a panoramic radiographic survey and a questionnaire. Number of missing teeth at baseline was analysed in a Cox proportional hazards model to estimate time to mortality and morbidity. Number of missing teeth, independently of socio-economic status variables (the husband’s occupational category, combined income, and education) was associated with increased all cause mortality and cardiovascular disease mortality respectively (relative risk (RR): 1.36; 95% confidence interval (95% CI): 1.18–1.58) and (RR: 1.46; 95% CI: 1.15–1.85 per 10 missing teeth), but no associations were found for cancer mortality (RR: 1.18; 95% CI: 0.91–1.52). The relation between poor oral health and future cardiovascular disease could not be explained by measures of socio-economic status in this study.
Similar content being viewed by others
References
WJ Loesche A Schork MS Terpenning et al. (1998) ArticleTitleAssessing the relationship between dental disease and coronary heart disease in elderly U.S. veterans J Am Dent Assoc 129 301–311 Occurrence Handle9529805 Occurrence Handle1:STN:280:DyaK1c7ptVOisg%3D%3D
K Paunio O Impivaara J Tiekso (1993) ArticleTitleMissing teeth and ischaemic heart disease in men aged 45–64 years Eur Heart J 14 IssueIDsuppl K 54–56 Occurrence Handle8131789
K Joshipura HC Hung EB Rimm WC Willett A Ascherio (2003) ArticleTitlePeriodontal disease, tooth loss, and incidence of ischemic stroke Stroke 34 47–52 Occurrence Handle12511749 Occurrence Handle10.1161/01.STR.0000052974.79428.0C
HC Hung W Willett A Merchant B Rosner A Ascherio K Joshipura (2003) ArticleTitleOral health and peripheral arterial disease Circulation 107 1152–1157 Occurrence Handle12615794 Occurrence Handle10.1161/01.CIR.0000051456.68470.C8
WJ Loesche (2000) ArticleTitlePeriodontal disease: link to cardiovascular disease Compend Contin Educ Dent 21 463–482 Occurrence Handle11199666 Occurrence Handle1:STN:280:DC%2BD3M7hvVWlsQ%3D%3D
JD Beck S Offenbacher (2001) ArticleTitleThe association between periodontal disease and cardiovascular disease: A state-of-the-science review Ann Periodontol 6 9–15 Occurrence Handle11887476 Occurrence Handle10.1902/annals.2001.6.1.9 Occurrence Handle1:STN:280:DC%2BD387lsFKqug%3D%3D
JD Beck S Offenbacher (2002) ArticleTitleRelationships among clinical measures of periodontol disease and their associations with systemic markers Ann Periodontol 7 79–89 Occurrence Handle16013220 Occurrence Handle10.1902/annals.2002.7.1.79
JD Beck S Offenbacher R Williams et al. (1998) ArticleTitlePeriodontitis: A risk factor for coronary heart disease? Ann Periodontol 3 127–141 Occurrence Handle9722697 Occurrence Handle1:STN:280:DyaK1czovF2hsw%3D%3D
KJ Joshipura EB Rimm CW Douglass et al. (1996) ArticleTitlePoor oral health and coronary heart disease J Dent Res 759 1631–1635
T Wu M Trevisan R Genco et al. (2000) ArticleTitleExamination of the relation between periodontal health status and cardiovascular risk factors: Serum total and high density lipoprotein cholesterol, C-reactive protein, and plasma fibrinogen Am J Epidemiol 151 273–282 Occurrence Handle10670552 Occurrence Handle1:STN:280:DC%2BD3c7jsVSisA%3D%3D
L Lapidus C Bengtsson (1986) ArticleTitleSocio-economic factors and physical activity in relation to cardiovascular disease and death: A 12-year follow up of participants in a population study of women in Gothenburg, Sweden Br Heart J 55 295–301 Occurrence Handle3954912 Occurrence Handle10.1136/hrt.55.3.295 Occurrence Handle1:STN:280:DyaL287lvFClug%3D%3D
C Cabrera Ö Helgesson H Wedel et al. (2001) ArticleTitleSocioeconomic status and mortality in Swedish women: Opposing trends for cardiovascular disease and cancer Epidemiology 12 532–536 Occurrence Handle11505172 Occurrence Handle10.1097/00001648-200109000-00012 Occurrence Handle1:STN:280:DC%2BD3MvlvVyrsw%3D%3D
C Bengtsson G Blohmé L Hallberg et al. (1973) ArticleTitleThe study of women in Gothenburg 1968–1969 – A population study, general design, purpose, and sampling results Acta Med Scand 193 311–318 Occurrence Handle4717311 Occurrence Handle1:STN:280:DyaE3s3hsFSgsw%3D%3D Occurrence Handle10.1111/j.0954-6820.1973.tb10583.x
C Bengtsson M Ahlqwist K Andersson (1997) ArticleTitleThe prospective population study of women in Gothenburg Sweden, 1968–69 to 1992–93: A 24-year follow up study with special reference to participation, representativeness, and mortality Scand J Health Care 15 214–219 Occurrence Handle10.3109/02813439709035031 Occurrence Handle1:STN:280:DyaK1c7gslWgsA%3D%3D
M Ahlqwist C Bengtsson M Hakeberg et al. (1999) ArticleTitleDental status of women in a 24-year longitudinal and cross-sectional study. Results from a population study of women in Göteborg Acta Odontol Scand 57 162–167 Occurrence Handle10480283 Occurrence Handle10.1080/000163599428904 Occurrence Handle1:STN:280:DyaK1MvgvVWlsg%3D%3D
Carlsson G. Socialgruppering. Social mobility and class structure. University of Lund, Sweden: GWK Gleerup. 1958.
A Halling C Bengtsson (1984) ArticleTitleNumber of teeth and proximal periodontal bone height in relation to social factors Swed Dent J 8 183–91 Occurrence Handle6594784 Occurrence Handle1:STN:280:DyaL2M%2Fms1ersg%3D%3D
M Parmar D Machin (1995) Survival analysis – A practical approach John Wiley and Sons Ltd Chichester
M Ahlqwist C Bengtsson H-G Gröndhal et al. (1991) ArticleTitleSocial factors and tooth loss in a 12 year follow-up study of women in Gothenburg, Sweden Community Dent Oral Epidemiol 19 141–146 Occurrence Handle1864065 Occurrence Handle10.1111/j.1600-0528.1991.tb00129.x Occurrence Handle1:STN:280:DyaK3Mzit12lsQ%3D%3D
I Johansson P Tidehag V Lundberg et al. (1994) ArticleTitleDental status, diet and cardiovascular risk factors in middle-aged people in northern Sweden Community Dent Oral Epidemiol 22 431–436 Occurrence Handle7882658 Occurrence Handle10.1111/j.1600-0528.1994.tb00792.x Occurrence Handle1:STN:280:DyaK2M7ovVGhtw%3D%3D
A Halling C Bengtsson RA Lenner (1988) ArticleTitleDiet in relation to number of remaining teeth in a population of middle-aged women in Gothenburg, Sweden Swed Dent J 12 39–45 Occurrence Handle3164916 Occurrence Handle1:STN:280:DyaL1c3nvVWjtA%3D%3D
PP Hujoel M Drangsholt C Spiekerman et al. (2000) ArticleTitlePeriodontal disease and coronary heart disease risk J Am Med Assoc 284 1406–1410 Occurrence Handle10.1001/jama.284.11.1406 Occurrence Handle1:STN:280:DC%2BD3cvktlKrtg%3D%3D
TH Howell PM Ridker UA Ajani et al. (2001) ArticleTitlePeriodontal disease and risk of subsequent cardiovascular disease in U.S. male physicians J Am Coll Cardiol 32 445–4450 Occurrence Handle10.1016/S0735-1097(00)01130-X
J Danesh (1999) ArticleTitleCoronary heart disease, Helicobacter pylori, dental disease, Chlamydia pneumoniae, and cytomegalovirus: meta-analyses of prospective studies Am Heart J 138 S434–S437 Occurrence Handle1:STN:280:DC%2BD3c%2FgslGksw%3D%3D Occurrence Handle10539843 Occurrence Handle10.1016/S0002-8703(99)70270-X
RJ Genco (2001) ArticleTitlePeriodontal disease and risk of coronary heart disease J Am Med Assoc 285 103 Occurrence Handle10.1001/jama.285.1.40
DF Kinane GDO Lowe (2000) ArticleTitleHow periodontal disease may contribute to cardiovascular disease Periodontology 23 121–126 Occurrence Handle10.1034/j.1600-0757.2000.2230112.x Occurrence Handle1:STN:280:DC%2BD3M7os1Wnsg%3D%3D
F DeStefano RF Anda HS Kahn et al. (1993) ArticleTitleDental disease and risk of coronary heart disease and mortality Br Med J 306 688–691 Occurrence Handle1:STN:280:DyaK3s3ivF2qtA%3D%3D
KJ Mattila MS Beiminen VV Valtonen et al. (1989) ArticleTitleAssociation between dental health and acute myocardial infarction Br Med J 298 779–781 Occurrence Handle1:STN:280:DyaL1M3ivFKitQ%3D%3D Occurrence Handle10.1136/bmj.298.6676.779
Herzberg MC, MacFarlane GD, Liu P, et al. The platelet as an inflammatory cell in periodontal diseases: interactions with Porphyromonas gingivalis. In: Genco RJ, Hamada S, Lehner T, et al. (eds), Molecular pathogenesis of periodontal disease. Washington, DC: American Society for Microbiology, 1994: 247–256.
DJ Caplan JA Weintraub (1993) ArticleTitleThe oral health burden in the United States: a summary of recent epidemiological studies J Dent Educ 57 853–62 Occurrence Handle8263233 Occurrence Handle1:STN:280:DyaK2c%2Fos1ymtQ%3D%3D
MC Downer (1991) ArticleTitleThe improving dental health of United Kingdom adults and prospects for the future Br Dent J 170 154–158 Occurrence Handle2007088 Occurrence Handle1:STN:280:DyaK3M7nsFaktg%3D%3D
A Hjern M Grindefjord H Sundberg et al. (2001) ArticleTitleSocial inequality in oral health and use of dental care in Sweden Community Dent Oral Epidemiol 29 167–74 Occurrence Handle11409675 Occurrence Handle10.1034/j.1600-0528.2001.290302.x Occurrence Handle1:STN:280:DC%2BD3Mzks1ymtA%3D%3D
AN Åström J Rise (2001) ArticleTitleSocio-economic differences in patterns of health and oral health behaviour in 25-year old Norwegians Clin Oral Investig 5 122–128 Occurrence Handle11480810 Occurrence Handle10.1007/s007840000102
Å Rundgren T Östeberg (1987) ArticleTitleDental health and parity in three 70-year old cohorts Commun Dent Oral Epidemiol 15 134–136 Occurrence Handle10.1111/j.1600-0528.1987.tb00500.x Occurrence Handle1:STN:280:DyaL2s3ksFegtw%3D%3D
RJ Genco (1994) ArticleTitleAssessment of risk of periodontal disease Compendium 18 IssueIDSuppl S678–S683 Occurrence Handle8039205
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Cabrera, C., Hakeberg, M., Ahlqwist, M. et al. Can the relation between tooth loss and chronic disease be explained by socio-economic status? A 24-year follow-up from the Population Study of Women in Gothenburg, Sweden. Eur J Epidemiol 20, 229–236 (2005). https://doi.org/10.1007/s10654-004-5961-5
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10654-004-5961-5