Abstract
Environmental pollution in many regions of Kazakhstan poses a threat to the growth and development of local children. For children living the near the Aral Sea, chrome processing and gas processing regions, we undertook a medical examination, including physical and sexual development parameters, laboratory studies (complete blood count, urinalysis, blood chemistry), bone age, blood levels of microelements (chromium, manganese, nickel, lead, copper) and hormones [thyroid (T3, T4, TSH), sexual (LH, FSH), growth (STH, IGF-1)], in consultation with relevant specialist doctors. Statistical analysis showed a significant prevalence of short stature among children living, on average, 22.9 versus 7.8% in the control region. Children in these regions have high blood levels of toxic chromium, manganese, lead and nickel compounds. The main causes of short stature in children living in the Aral Sea, chrome processing and oil and gas processing regions are cerebral–endocrine pathologies, hereditary diseases, somatogenic diseases, constitutional growth delay, a toxic chemical load and ecologically determined short stature. A working classification of short stature in children living in the Aral Sea, chrome processing and gas processing regions, including ecologically dependent short stature, has been developed. The scheme of medical and recreational measures for children living in the Aral Sea, chrome processing and gas processing regions was proposed.
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References
Avtsyn, A. P., Zhavoronkov, A. A., Rish, M. A., & Strochkova, L. S. (1991). Mikroelementozy rights. Moscow: Medicine.
Bayevsky, R. M. (1990). Prediction of conditions on the verge of norm and pathology. Moscow: “M”.
Bermagambetova, S. K., Zhumalina, A. K., Tusupkalieva, K Sh, Tusupkaliev, B., & Tuyakbaev, A. M. (2008). Linkage of morbidity indicators with the level of microelements of blood in children living near chrome-mining and processing enterprises. Batys Kazakh Medical Journal, 4(20), 79–81.
Blunk, W. (1981). Pediatric endocrinology. Moscow: Medicine.
Bobak, M., & David, A. L. (1999). Pregnancy outcomes and outodoor air pollution: An ecological study in regions of the Czech Republic 1986–1998. Occupational and Environmental Medicine, 8(56), 539–543.
Bukina, L. G., Kuznetsova, A. P., & Leontieva, T. N. (2007). The physical development of girls in an industrial city. Physiology of humans and animals: from experiment to clinical practice: theses. doc. VI youth scientific. Conf. Institute of Physiology, Komi Science Center, Ural Branch of the Russian Academy of Sciences, March 20–22, Syktyvkar.
Bunak, V. V. (1941). Anthropometry. Moscow: Uchpedgiz.
Cowveina, N. B., Bremner, S. A., & Novaes, N. (2004). Association of ambient air pollution and birth in San Paulo. Journal of Epidemiology and Community Health, 1(58), 11–17.
Dementieva, G. M., Kozlova, A. E., & Nissan, L. G. (1984). Evaluation of the physical development of newborns. Moscow: Nauka.
do Nascimento, S., de Andrade Júnior, F. P., Alves, T. W. B., & Menezes, M. E. S. (2018). Seeds of chia (salviahispanica L.) as an agent in prevention, treatment and control of some diseases chronicles: A review. Periódico Tchê Química, 15(30), 402–414.
Iztleuova, G. M., Mavlyudova, N. M., Iztlev, E. M., & Iztlevov, M. K. (2009). Nephroprotective effect of the oil extract of nettle leaves and lipoic acid in chroinduced nephropathy. Batys Kazakh Medical Journal, 3(23), 32.
Karimov, T. K., & Shkolbulova, D. T. (2008). Negative influence of industrial enterprises on the river Ilek of Aktobe region. Health and Disease, 9(75), 30–31.
Kuchma, V. R. (2002). Assessment of the risk of the influence of environmental factors on the health of children and adolescents. Hygiene and Sanitation, 6, 51–53.
Liu, Sh, Krewski, D., Shi, Y., Che, Y., & Burnett, R. T. (2003). Association between gaseous ambient air pollutants and pregnancy in vancouver. Environmental Health Perspectives, 14(111), 1773–1778.
Lyalikov, S. A., & Lyalikova, V. I. (2008). Periodization of childhood on the basis of anthropometric indicators. Journal of the State Min and Metal Universe, 4, 28–32.
Mukyshova, G. D., Iztleuov, M. K., Sundetov, Zh S, Omarova, K. P., & Iztleuov, E. M. (2009). Correction of the hemothoxic effect of hexavalent chromium. Batys Kazakh Medical Journal, 3(23), 38.
Perepust, L. A. (1977). Determination of age according to roentgenograms of the bones of the hand. Method of recommendation. Kiev: Vyshcha shkola.
Revich, B. A., Avaliani, S. L., & Tikhonova, G. I. (2004). Ecological epidemiology. Moscow: Academy.
Sharova, A. A., Volevodz, N. N., & Peterkova, V. A. (2006). Low growth in children: Causes, differential diagnosis and treatment options (literature review). Reproductive Health of Child and Adolescents, 3, 53–63.
Silver, H. K., Kiyasu, W., George, J., & Deamcr, W. C. (1953). Syndrome of congenital hemihypertrophy, shortness of stature and elevated urinary gonadotrophins. Pediatrics, 12, 368–376.
Skalnyi, A. V. (2000). Human microelementoses: Hygiene diagnosis and correction. Microelements in Medicine, 1, 2–8.
Sobolev, V. A., Zemlyanaya, G. M., & Revazova, Yu A. (2007). Conducting medical examinations of children living in sanitary-epidemiologically unfavorable territories. Hygiene and Sanitation, 4, 22–27.
Stavitskaya, A. B., & Aron, D. I. (1959). Methods of studying the physical development of children and adolescents. Moscow: Medgiz.
Uzunova, A. N., Tsvetova, I. P., Neryakhina, S. V., Lopatin, O. V., & Zaitsev, M. L. (2008). Features of physical development in the zone of environmental problems. Hygiene and Sanitation, 2, 89–91.
Vasiliev, A. V. (2005). Physiometric indicators of children living in areas with different levels of aerotechnogenic load. Hygiene and Sanitation, 1, 39–40.
Vitebskaya, A. V. (2007). Modern trends in the diagnosis and therapy of idiopathic stuntedness. Problems of Endocrinology, 1, 46–53.
Zhukovsky, M. A. (1982). Pediatric endocrinology. Moscow: Medicine.
Zhumalina, A. K., Zhilkibaeva, B Zh, & Tungatarova, M. A. (2008). Problems of stunting in children living in ecologically disadvantaged regions. The possibilities of early diagnosis at the present stage. Bulletin of the Kazakhstan Natural Medicine Universe, 1, 102–103.
Acknowledgements
The study was carried out within the framework of grant financing of scientific research activities of the Ministry of Education and Science of the Republic of Kazakhstan for 2013–2015 for The Improvement of Technologies for Children’s Health Care and Reproductive Health, Registration number of NTI: 0113RK00439.
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Zhumalina, A.K., Bekmukhambetov, E.Z., Tusupkaliev, B.T. et al. Development of scientifically justified proposals on the prevention and treatment of environmentally determined constitutional growth delay in children in the West Kazakhstan region. Environ Geochem Health 41, 1251–1265 (2019). https://doi.org/10.1007/s10653-018-0210-0
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DOI: https://doi.org/10.1007/s10653-018-0210-0