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The UK geochemical environment and cardiovascular diseases: magnesium in food and water

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Abstract

Cardiovascular diseases (CVDs) contribute approximately one-third to noncommunicable diseases in the UK. The central role of magnesium in CVDs (enzyme activity, cardiac signalling, etc.) is well established. Mortality and morbidity rates for CVDs may be inversely related to water hardness, suggesting a role for environmental magnesium. Published official and quasi-official data sources were evaluated to establish a model magnesium intake for a representative adult: standardised reference individual (SRI), standardised reference male (SRM) or standardised reference female (SRF). For typical dietary constituents, only tap water is probably locally derived and bottled water may not be. Fruits and vegetables are imported from many countries, while meat, dairy and cereal products represent a composite of UK source areas. Alcoholic beverages provide magnesium, there is doubt about its absorptive efficiency, and they are not locally derived. A simple model was devised to examine the effect of varying dietary contributions to total daily intake of magnesium. Omitting tap or bottled water, the combined intake, solid food plus alcoholic beverages, is 10.57 mmol Mg (84.5 % RNI) for the SRM and for the SRF, 8.10 mmol Mg (71.7 % RNI). Consumers drinking water derived from reservoirs or rivers, or supplementing it with the purest bottled water, improve their magnesium intake only slightly compared with water containing no magnesium. Choosing bottled water with high magnesium content when the public supply derives from rivers or reservoirs partially satisfies magnesium needs. Real improvement in SRI magnesium nutrition is seen only where water is hard. However, this conclusion cannot be validated until new measurement technologies for body magnesium become available.

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References

  • Acton, L. (2011). Allotment gardens: A reflection of history, heritage, community and self. Papers from the Institute of Archaeology, 21, 46–58.

    Article  Google Scholar 

  • Agus, Z. S., & Morad, M. (1991). Modulation of cardiac ion. Annual Review of Physiology, 53(4), 299–307.

    Article  CAS  Google Scholar 

  • Alwan, L., Armstrong, A., Cowan, T., & Riley, M, (eds) (2011) Non communicable diseases: Country profiles 2011, (p. 209). Geneva: World Health Organization

  • Ames, B. N., Atamna, H., & Killilea, D. W. (2005). Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging. Molecular Aspects of Medicine, 26(4–5), 363–378.

    Article  CAS  Google Scholar 

  • Ardagh, J. (2011). The 2011 Uk soft drinks report (p. 24). 20–22 Stukeley Street London WC2B 5LR: British Soft Drinks Association.

  • Baghurst, K. (2006). Nutrient reference values for Australia and New Zealand (p. 317). Canberra: Commonwealth of Australia.

  • Barbagallo, M., Belvedere, M., & Dominguez, L. J. (2009). Magnesium homeostasis and aging. Magnesium Research, 22, 235–246.

  • Bates, B., Lennox, A., Prentice, A., & Bates, C. (2012). National diet and nutrition survey (Vol. 3, pp. 1–79). London.

  • Bennion, H., & Harriman, R. B. (1997). A chemical survey of standing waters in south-east england, with reference to acidification and eutrophication. Fresh water forum, 8, 28–44.

    Google Scholar 

  • Bohn, T., Davidsson, L., Walczyk, T., & Hurrell, R. F. (2004a). Fractional magnesium absorption is significantly lower in human subjects from a meal served with an oxalate-rich vegetable, spinach, as compared with a meal served with kale, a vegetable with a low oxalate content. The British Journal of Nutrition, 91, 601–606.

    Article  CAS  Google Scholar 

  • Bohn, T., Walczyk, T., Davidsson, L., Pritzkow, W., Klingbeil, P., Vogl, J., & Hurrell, R. F. (2004b). Comparison of urinary monitoring, faecal monitoring and erythrocyte analysis of stable isotope labels to determine magnesium absorption in human subjects. British Journal of Nutrition, 91(01), 113.

    Article  CAS  Google Scholar 

  • Chakraborti, S., Chakraborti, T., Mandal, M., Mandal, A., Das, S., & Ghosh, S. (2002). Protective role of magnesium in cardiovascular diseases: A review. Molecular and Cellular Biochemistry, 238, 163–179.

    Article  CAS  Google Scholar 

  • Cowan, J. A. (2002). Structural and catalytic chemistry of magnesium-dependent enzymes. Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine, 15, 225–235.

    Article  CAS  Google Scholar 

  • Crawford, T., & Crawford, M. (1967). Prevalence and pathological changes of ischæmic heart-disease in a hard-water and in a soft-water area. The Lancet, 289(7484), 229–232.

    Article  Google Scholar 

  • Crawford, M., Gardner, M. J., & Morris, J. N. (1968). Mortality and hardness of local water-supplies. The Lancet, 291(7547), 827–831.

    Article  Google Scholar 

  • Davies, B. E., Bowman, C., Davies, T. C., & Selinus, O. (2013). Medical geology: Perspectives and prospects. In O. Selinus (Ed.), Essentials of Medical Geology (pp. 1–13). Dordrecht: Springer.

    Chapter  Google Scholar 

  • Davies, B. E., & White, H. (1981). Trace elements in vegetables grown on soils contaminated by base metal mining. Journal of Plant Nutrition, 3, 387–396.

    Article  CAS  Google Scholar 

  • De Bon, H., Parrot, L., & Moustier, P. (2010). Sustainable urban agriculture in developing countries: A review. Agronomy for Sustainable Development, 30, 21–32.

    Article  Google Scholar 

  • DEFRA. (2010). UK Food Security Assessment : Detailed analysis UK food security assessment: Detailed analysis (pp. 1–145). London: Department for Environment, Food and Rural Affairs.

  • DEFRA. (2012). Food statistics pocketbook (p. 85). London, England: Department for Environment, Food and Rural Affairs.

  • DEFRA. (2013). Basic horticultural statistics 2013 (p. 23). London, England: Department for Environment, Food and Rural Affairs.

  • Del Gobbo, L. C., Elin, R. J., Poirier, P., & Egeland, G. M. (2012). Serum magnesium: A biomarker of cardiovascular risk revisited? Magnesium Research: Official organ of the International Society for the Development of Research on Magnesium, 25, 49–53.

    Google Scholar 

  • DH (1991) Dietary reference values for food energy and nutrients for the United Kingdom: Report of the panel on dietary reference values of the committee on medical aspects of food policy; volume 41 of Report on Health and Social Subjects Series; Great Britain. Department of Health; Stationery Office, 1991

  • DWI. (2009). national tap water consumption study (p. 58). London, England.

  • Elin, R. J. (1987). Assessment of magnesium status. Clinical Chemistry, 33, 1965–1970.

    CAS  Google Scholar 

  • Elwood, P. C. (1994). Iron, magnesium and ischaemic heart disease. The Proceedings of the Nutrition Society, 53, 599–603.

    Article  CAS  Google Scholar 

  • Erenstein, O., Oswald, A., & Mahaman, M. (2006). Determinants of lowland use close to urban markets along an agro-ecological gradient in West Africa. Agriculture, Ecosystems & Environment, 117, 205–217.

    Article  Google Scholar 

  • Fawcett, W. J., Haxby, E. J., & Male, D. A. (1999). Magnesium: Physiology and pharmacology. British Journal of Anaesthesia, 83, 302–320.

    Article  CAS  Google Scholar 

  • Fine, K. D., Santa Ana, C. A., Porter, J. L., & Fordtran, J. S. (1991). Intestinal absorption of magnesium from food and supplements. The Journal of Clinical Investigation, 88, 396–402.

    Article  CAS  Google Scholar 

  • Gibney, M. J., Lanham-News, S., Cassidy, A., & Vorster, H. H. (2009). Introduction to human nutrition. In: Gibney, M. J., Lanham-News, S., Cassidy, A., Vorster, H. H. (Ed.) (2nd ed., p. 386). Chichester, West Sussex, PO19 8SQ: Wiley-Blackwell.

  • Harper, D. M. (1990). The ecology of a lowland sandstone river: The river Perry, Shropshire. Field Studies, 7, 451–468.

  • Ilbery, B., Courtney, P., Kirwan, J., & Maye, D. (2010). Marketing concentration and geographical dispersion: A survey of organic farms in England and Wales. British Food Journal, 112, 962–975.

    Article  Google Scholar 

  • Ilbery, B., Watts, D., Simpson, S., Gilg, A., & Little, J. (2006). Mapping local foods: Evidence from two English regions. British Food Journal, 108, 213–225.

    Article  Google Scholar 

  • Jahnen-Dechent, W., & Ketteler, M. (2012). Magnesium basics. Clinical Kidney Journal, 5(Suppl 1), i3–i14.

    Article  CAS  Google Scholar 

  • Johnson, C. J., Peterson, D. R., & Smith, E. K. (1979). Myocardial tissue concentrations of magnesium and potassium in men dying suddenly from ischemic heart disease. The American Journal of Clinical Nutrition, 32, 967–970.

    CAS  Google Scholar 

  • Kobayashi, J. (1957). On geographical relationship between the chemical nature of river water and death-rate from apoplexy. Berichte des Ohara Instituts fur landwirtschaftliche Biologie, 9, 12–21.

    Google Scholar 

  • Laires, M. J., Monteiro, C. P., & Bicho, M. (2004). Role of cellular magnesium in health and human disease. Frontiers in Bioscience, 9, 262–276.

    Article  Google Scholar 

  • Macdiarmid, J., Kyle, J., Horgan, G., Loe, J., Fyfe, C., Johnstone, A., & McNeill, G. (2011). Livewell: A balance of healthy and sustainable food choices (p. 64). Aberdeen, Scotland.

  • Maheswaran, R., Morris, S., Falconer, S., Grossinho, A., Perry, I., Wakefield, J., & Elliott, P. (1999). Magnesium in drinking water supplies and mortality from acute myocardial infarction in north west England. Heart (British Cardiac Society), 82, 455–460.

    CAS  Google Scholar 

  • Maier, J. M. (2003). Low magnesium and atherosclerosis: An evidence-based link. Molecular Aspects of Medicine, 24, 137–146.

    Article  CAS  Google Scholar 

  • Marx, A., & Neutra, R. R. (1997). Magnesium in drinking water and ischemic heart disease. Epidemiologic Reviews, 19, 258–272.

    Article  CAS  Google Scholar 

  • Masironi, R., & Shaper, A. G. (1981). Epidemiological studies of health effects of water from different sources. Annual Review of Nutrition, 1, 375–400.

    Article  CAS  Google Scholar 

  • McCance, R. A., & Widdowson, E. W. (2002). McCance and Widdowson’s The composition of foods (pp 1–537). The Royal Society of Chemistry.

  • Mensink, G. B. M., Fletcher, R., Gurinovic, M., Huybrechts, I., Lafay, L., Serra-Majem, L., & Stephen, M. (2013). Mapping low intake of micronutrients across Europe. The British Journal of Nutrition, 110, 755–773.

    Article  CAS  Google Scholar 

  • Morrisa, R. W., Walker, M., Lennon, L. T., Shaper, A. G., & Whincup, P. H. (2008). Hard drinking water does not protect against cardiovascular disease: New evidence from the British Regional Heart Study. European Journal of Preventive Cardiology, 15, 185–189.

    Article  Google Scholar 

  • Motulsky, A. G. (1989). Diet and health: Implications for reducing chronic disease risk (p. 766). Washington, DC: National Research Council.

  • Nantel, G., & Tontisirin, K. (2001). Human vitamin and mineral requirements: Report of a joint FAO/WHO expert consultation Bangkok, Thailand (p. 303). Rome, Italy: FAO–UN.

  • Otten, J., Hellwig, P., & Mayers, L. D. (Ed.). (2006). Dietary DRI reference intakes (p. 1344). Washington, DC: The National Academies Press.

  • Pearson, T. A., Blair, S. N., Daniels, S. R., Eckel, R. H., Fair, J. M., Fortmann, S. P., et al. (2002). AHA guidelines for primary prevention of cardiovascular disease and stroke: 2002 Update: Consensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases. Circulation, 106(3), 388–391.

    Article  Google Scholar 

  • Pollard, J., Kirk, S. F. L., & Cade, J. E. (2002). Factors affecting food choice in relation to fruit and vegetable intake: A review. Nutrition Research Reviews, 15(2), 373–387.

    Article  CAS  Google Scholar 

  • Reynolds, B., Stevens, P., Brittain, S. A., Norris, D. A., Hughes, S., & Woods, C. (2004). Long-term changes in precipitation and stream water chemistry in small forest and moorland catchments at Beddgelert Forest, north Wales. Hydrology and Earth System Sciences, 8, 436–448.

    Article  CAS  Google Scholar 

  • Romani, A. M. P., & Maguire, M. E. (2002). Hormonal regulation of Mg2+ transport and homeostasis in eukaryotic cells. BioMetals, 15, 271–283.

    Article  CAS  Google Scholar 

  • Rosanoff, A., Weaver, C. M., & Rude, R. K. (2012). Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutrition reviews, 70, 153–164.

  • Rosenlund, M., Berglind, N., Hallqvist, J., Bellander, T., & Bluhm, G. (2005). Daily intake of magnesium and calcium from drinking water in relation to myocardial infarction. Epidemiology, 16, 570–576.

    Article  Google Scholar 

  • Rubenowitz, E., Axelsson, G., & Rylander, R. (1996). Magnesium in drinking water and death from acute myocardial infarction. American Journal of Epidemiology, 143, 456–462.

    Article  CAS  Google Scholar 

  • Rylander, R., Mégevand, Y., Lasserre, B., Amstutz, W., & Granbom, S. (2001). Moderate alcohol consumption and urinary excretion of magnesium and calcium. Scandinavian Journal of Clinical and Laboratory Investigation, 61, 401–405.

    Article  CAS  Google Scholar 

  • Sabatier, M., Pont, F., Arnaud, M. J., & Turnlund, J. R. (2003). A compartmental model of magnesium metabolism in healthy men based on two stable isotope tracers. American journal of physiology. Regulatory, Integrative and Comparative Physiology, 285, R656–R663.

    Article  Google Scholar 

  • Saris, N. E., Mervaala, E., Karppanen, H., Khawaja, J. A., & Lewenstam, A. (2000). Magnesium. An update on physiological, clinical and analytical aspects. Clinica Chimica Acta, 294, 1–26.

    Article  CAS  Google Scholar 

  • Sasaki, S., Oshima, T., Matsuura, H., Ozono, R., Higashi, Y., Sasaki, N., Matsumoto, T., Nakono, Y., Ueda, A., Yoshimizu, A., Kurisu, S., Kambe, M., Kajiyama, G. (2000). Abnormal magnesium status in patients with cardiovascular diseases. Clinical Science, 98, 175–81.

  • Shand, P., Edmunds, W. M., Lawrence, A. R., Smedley, P., & Burke, S. (2007). The natural (baseline) quality of groundwater in England and Wales (p. 84). Keyworth, Nottingham: British Geological Survey and UK Environment Agency.

  • Shechter, Michael. (2010). Magnesium and cardiovascular system. Magnesium Research: Official organ of the International Society for the Development of Research on Magnesium, 23, 60–72.

    CAS  Google Scholar 

  • Shi, Y., Liu, H., Gai, D., Ma, J., & Chen, X. S. (2009). A computational analysis of ATP binding of SV40 large tumor antigen helicase motor. PLoS Computational Biology, 5(9).

  • Smedley, P. L. (2010). A survey of the inorganic chemistry of bottled mineral waters from the British Isles. Applied Geochemistry, 25, 1872–1888.

    Article  CAS  Google Scholar 

  • Steinnes, E. (2009). Soils and geomedicine. Environmental Geochemistry and Health, 31, 523–535.

    Article  CAS  Google Scholar 

  • Sutcliffe, D. (2010). The ionic composition of surface waters in the English Lake District, related to bedrock geology, with some singular facts and speculation on the existence of mineral-rich groundwaters. Fresh Water Forum, 11, 30–51.

  • Townsend, N., Wickramasinghe, K., Bhatnagar, P., Smolina, K., Nichols, M., Leal, J., & Luengo-Fernandez, R., & Rayer, M. (2012). Coronary heart disease statistics (p. 208). Oxford: British Heart Foundation Health Promotion Research Group, Department of Public Health, University of Oxford.

  • White, H. M. F. (2000). Buyer-supplier relationships in the UK fresh produce industry. British Food Journal, 102, 6–17.

    Article  Google Scholar 

  • WHO. (2011). Non communicable diseases: Country profiles 2011. In: Alwan, L. Armstrong, A., Cowan, T., & Riley, M. (Ed.) (p. 209). Geneva: World Health Organization.

  • Wilson, N. (1996). The supply chains of perishable products in northern Europe. British Food Journal, 98, 9–15.

    Article  Google Scholar 

  • Winter, T. C., Harvey, J. W., Franke, O. L., Alley, W. M. (1998). Ground water and surface water: A single resource (p. 87). Denver, Colorado: U.S. Geological Survey Circular 1139.

  • Wolf, F. I., Torsello, A., Fasanella, S., & Cittadini, A. (2003). Cell physiology of magnesium. Molecular Aspects of Medicine, 24, 11–26.

    Article  CAS  Google Scholar 

  • Wu, C., & Kenny, M. A. (1996). Circulating total and ionized magnesium after ethanol ingestion. Clinical Chemistry, 42, 625–629.

    CAS  Google Scholar 

  • Wyss, M., & Kaddurah-Daouk, R. (2000). Creatine and creatinine metabolism. Physiological Reviews, 80, 1107–1213.

    CAS  Google Scholar 

  • Young, V. R. (1997). Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and Fluoride (p. 449). Washington: National Academy Press.

  • Yusuf, S., Reddy, S., Ounpuu, S., & Anand, S. (2001). Global burden of cardiovascular diseases: Part I: General considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation, 104, 2746–2753.

    Article  CAS  Google Scholar 

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  1. Clemson University, Clemson, SC, USA

    B. E. Davies

  2. 3 Old Hall Barns, Markfield Road, Groby, Leicestershire, LE6 0FL, UK

    B. E. Davies

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Davies, B.E. The UK geochemical environment and cardiovascular diseases: magnesium in food and water. Environ Geochem Health 37, 411–427 (2015). https://doi.org/10.1007/s10653-014-9671-y

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