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Antiangiogenic properties of an unusual benzo[k,l]xanthene lignan derived from CAPE (Caffeic Acid Phenethyl Ester)

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Summary

Angiogenesis is normally a highly regulated process that occurs during development, reproduction, and wound repair. However, angiogenesis can also become a fundamental pathogenic process in cancer and several other diseases. To date, the synthesis of angiogenesis inhibitors has been researched in several ways also starting from bioactive plant compounds. In the present study, we tested both in an angiogenesis bioassay and in ovarian cell culture, the potential antiangiogenic effect of a natural-derived benzo[k,l]xanthene lignan (5). This unusual compound was synthesized through the biomimetic dimerization of CAPE (Caffeic Acid Phenetyl Ester), a bioactive component of honeybee propolis. The lignan showed a significant, dose-related inhibitory effect on new vessel growth in the angiogenesis bioassay and it inhibited Vascular Endothelial Growth Factor secretion in ovarian cell culture. Therefore, we indicate the natural-derived benzo[k,l]xanthene lignan 5 as a potential new angiogenesis inhibitor.

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Acknowledgements

Supported by MIUR, Ministero dell’Università e della Ricerca (PRIN, Rome, Italy), Università degli Studi di Catania (PRA, Catania, Italy) and Università degli Studi di Parma (FIL, Parma, Italy).

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Authors and Affiliations

  1. Dipartimento di Produzioni Animali, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti—Sezione di Fisiologia Veterinaria, Università degli Studi di Parma, Via del Taglio 10, 43126, Parma, Italy

    Giuseppina Basini, Laura Baioni, Simona Bussolati & Francesca Grasselli

  2. Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, 95125, Catania, Italy

    Carmelo Daquino, Carmela Spatafora & Corrado Tringali

Authors
  1. Giuseppina Basini
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  2. Laura Baioni
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  3. Simona Bussolati
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  4. Francesca Grasselli
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  5. Carmelo Daquino
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  6. Carmela Spatafora
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  7. Corrado Tringali
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Correspondence to Giuseppina Basini.

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Basini, G., Baioni, L., Bussolati, S. et al. Antiangiogenic properties of an unusual benzo[k,l]xanthene lignan derived from CAPE (Caffeic Acid Phenethyl Ester). Invest New Drugs 30, 186–190 (2012). https://doi.org/10.1007/s10637-010-9550-z

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  • DOI: https://doi.org/10.1007/s10637-010-9550-z

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