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A case of melanoma-associated retinopathy with autoantibodies against TRPM1

  • Clinical Case Report
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Abstract

Purpose

To report a case of melanoma-associated retinopathy (MAR) with autoantibodies against the transient receptor potential cation channel, subfamily M, member 1 (TRPM1) with asymmetric severe vision loss.

Methods

We evaluated a patient with heel skin melanoma showing progressive vision loss in both eyes confirmed with a baseline ophthalmic examination, fluorescein angiography, spectral domain optical coherence tomography (OCT), visual field test, and full-field electroretinogram (ERG). Immunofluorescence assays and western blot analysis revealed autoantibodies in the patient’s serum.

Results

The patient’s best-corrected visual acuities were 20/50 in the right eye and hand motion in the left eye. Visual field test showed severely depressed visual fields especially in the left eye. Fluorescein angiography and OCT revealed extrafoveal choroidal neovascularization in the left eye. The patient had an electronegative ERG, suggesting MAR, and autoantibodies against TRPM1 and aldolase C were detected in the patient’s blood sample.

Conclusions

The clinical features of MAR patients with positive anti-TRPM1 autoantibodies can be manifested as severe vision loss, and the identification of autoantibodies can be helpful for confirming the diagnosis.

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Acknowledgements

This study was supported by Grant No. 14-2018-019 from the SNUBH Research Fund.

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Authors and Affiliations

  1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, South Korea

    Min Seok Kim, Hye Kyoung Hong, You Jin Ko, Kyu Hyung Park, Se Joon Woo & Kwangsic Joo

  2. Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Shinji Ueno & Satoshi Okado

Authors
  1. Min Seok Kim
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  2. Hye Kyoung Hong
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  3. You Jin Ko
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  4. Kyu Hyung Park
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  5. Shinji Ueno
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  6. Satoshi Okado
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  7. Se Joon Woo
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  8. Kwangsic Joo
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Correspondence to Kwangsic Joo.

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All authors certify that they have no affiliations with or involvement in any organization or entity with a financial interest (such as honoraria, educational grants, participation in speaker’s bureaus, membership, employment, consultancies, stock ownership or other equity interest, and expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationship, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee, and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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All applicable international, national and/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.

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Kim, M.S., Hong, H.K., Ko, Y.J. et al. A case of melanoma-associated retinopathy with autoantibodies against TRPM1. Doc Ophthalmol 141, 313–318 (2020). https://doi.org/10.1007/s10633-020-09772-1

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  • DOI: https://doi.org/10.1007/s10633-020-09772-1

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