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Assessing the Efficacy and Outcomes Following Irrigation with Streptokinase Versus Hydrogen Peroxide in Necrotizing Pancreatitis: A Randomized Pilot Study

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Abstract

Background

Percutaneous catheter drainage (PCD’s) are prone to blockage because of necrosum. To improve the efficacy of PCD, necrolytic agents have been used. The present study compared the use of Streptokinase with H2O2 in saline irrigation.

Materials and Methods

This is a single-center randomized pilot study (from July 2018 to Dec 2019). Patients with infected pancreatic necrosis not showing response to PCD and saline irrigation were included in the study. Patients received either Streptokinase (Streptokinase group 50,000 IU in 100 ml normal saline) or 3% H2O2 (3% H2O2 in 100 ml normal saline in 1:10 dilution). Primary endpoints were the need for surgery and mortality while secondary endpoints were hospital stay and complications attributable to necrolytic agents.

Results

There were 30 patients in the study, 15 in each arm. Organ failure was seen in 23 (76.6%), single organ failure was present in 11 (47%), and multi-organ failure in 12 (53%). Bleeding complications (20% in H2O2 vs 6.6% in Streptokinase), need for surgery (73% in H2O2 vs 33.3% in Streptokinase) and mortality (60% in H2O2 vs 33% in Streptokinase) were higher in H2O2 group but the difference was not significant statistically. Post-irrigation hospital stay was lesser in the Streptokinase group compared to H2O2 group but the difference did not reach statistical significance (14.1 ± 7.7 vs 19.2 ± 11.7, p = 0.09)

Conclusions

Streptokinase irrigation led to a trend for reduced need for necrosectomy and mortality. H2O2 group had more bleeding complications. Post-irrigation hospital stay was lesser in Streptokinase group.

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Authors and Affiliations

  1. Department of Surgical Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India

    Rajesh Gupta

  2. Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India

    Surinder Singh Rana

  3. Department of Radio Diagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India

    Ujjwal Gorsi & Mandeep Kang

Authors
  1. M. Venu Bhargava
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  2. Surinder Singh Rana
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  3. Ujjwal Gorsi
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  4. Mandeep Kang
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  5. Rajesh Gupta
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Correspondence to Rajesh Gupta.

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Bhargava, M.V., Rana, S.S., Gorsi, U. et al. Assessing the Efficacy and Outcomes Following Irrigation with Streptokinase Versus Hydrogen Peroxide in Necrotizing Pancreatitis: A Randomized Pilot Study. Dig Dis Sci 67, 4146–4153 (2022). https://doi.org/10.1007/s10620-021-07201-0

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  • DOI: https://doi.org/10.1007/s10620-021-07201-0

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