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Recent Advances in Prevention and Therapies for Clinical or Experimental Necrotizing Enterocolitis

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Abstract

Necrotizing enterocolitis (NEC) is one of the most severe diseases of preterm neonates and has a high mortality rate. With the development of inspection techniques and new biomarkers, the diagnostic accuracy of NEC is constantly improving. The most recognized potential risk factors include prematurity, formula-feeding, infection, and microbial dysbiosis. With further understanding of the pathogenesis, more effective prevention and therapies will be applied to clinical or experimental NEC. At present, such new potential prevention and therapies for NEC are mainly focused on the Toll-like receptor 4 inflammatory signaling pathway, the repair of intestinal barrier function, probiotics, antioxidative stress, breast-feeding, and immunomodulatory agents. Many new studies have changed our understanding of the pathogenesis of NEC and improve our approaches for preventing and treating of NEC each year. This review provides an overview of the recent researches focused on clinical or experimental NEC and highlights the advances made within the past 5 years toward the development of new potential preventive approaches and therapies for this disease.

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Authors and Affiliations

  1. Department of Gastrointestinal Surgery, The First Hospital of China Medical University, Shenyang, 110001, Liaoning Province, China

    Kewei Wang

  2. Department of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA

    Kewei Wang, Guozhong Tao & Karl G. Sylvester

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  1. Kewei Wang
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Wang, K., Tao, G. & Sylvester, K.G. Recent Advances in Prevention and Therapies for Clinical or Experimental Necrotizing Enterocolitis. Dig Dis Sci 64, 3078–3085 (2019). https://doi.org/10.1007/s10620-019-05618-2

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