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Heavy Coffee Consumption and Risk of Pancreatitis: A Systematic Review and Meta-Analysis

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Abstract

Background/Objectives

Heavy consumption of coffee may have a protective effect against pancreatitis although results from previous studies were inconsistent. This meta-analysis was conducted with the aim to summarize all available data.

Methods

This meta-analysis included observational studies that compared the risk of pancreatitis between heavy coffee-drinkers and individuals who were not heavy coffee-drinkers. Pooled risk ratios (RRs) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method.

Results

Out of 219 retrieved articles, four studies with 351,137 participants met the eligibility criteria and were included in the analysis. The risk of pancreatitis among heavy coffee-drinkers was significantly lower than individuals who were not heavy coffee-drinkers with the pooled RR of 0.78 (95% CI 0.67–0.91). The statistical heterogeneity between the studies was insignificant (I2 = 0%).

Conclusions

This meta-analysis demonstrated a significantly decreased risk of pancreatitis among heavy coffee-drinkers. However, further investigations are still required to determine causality and potential clinical application.

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Authors and Affiliations

  1. Department of Internal Medicine, Bassett Medical Center, One Atwell Road, Cooperstown, NY, 13326, USA

    Karn Wijarnpreecha

  2. Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

    Panadeekarn Panjawatanan

  3. Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Mayo Clinic, Jacksonville, FL, USA

    Karn Wijarnpreecha, Omar Y. Mousa & Surakit Pungpapong

  4. Department of Medicine, Division of Nephrology, University of Mississippi Medical Center, Jackson, MS, USA

    Wisit Cheungpasitporn

  5. Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Patompong Ungprasert

Authors
  1. Karn Wijarnpreecha
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  2. Panadeekarn Panjawatanan
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  3. Omar Y. Mousa
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  4. Wisit Cheungpasitporn
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  5. Surakit Pungpapong
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  6. Patompong Ungprasert
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All authors had access to the data and a role in writing the manuscript.

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Correspondence to Karn Wijarnpreecha.

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The authors have no commercial associations that might be a conflict of interest in relation to this article.

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Wijarnpreecha, K., Panjawatanan, P., Mousa, O.Y. et al. Heavy Coffee Consumption and Risk of Pancreatitis: A Systematic Review and Meta-Analysis. Dig Dis Sci 63, 3134–3140 (2018). https://doi.org/10.1007/s10620-018-5214-1

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  • DOI: https://doi.org/10.1007/s10620-018-5214-1

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