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Association Between Adipokines Levels with Inflammatory Bowel Disease (IBD): Systematic Reviews

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Abstract

Background

A combination of genetic and environmental factors is involved in the etiology of inflammatory bowel disease (IBD). Recent studies have shown that adipocytes play a crucial role, by actively participating in systemic immune responses in IBD patients. But findings remain controversial. To the best of our knowledge, no systematic review has evaluated the roles of adipokines in IBD, considering which this systematic review was undertaken to summarize the effects of these adipokines in IBD pathogenesis.

Methods

For this review, articles published between 1980 and 2016 were identified from the PubMed, EMBASE, Scopus, and Cochrane and Google scholar databases. Thirteen articles were ultimately selected for inclusion in this systematic review.

Results

Findings of the present study indicate that some of the adipokines such as leptin, adiponectin and resistin are associated with disease severity, body composition and glucose hemostasis in IBD patients, although some of these associations are stronger than others.

Conclusions

Overall findings indicate that some adipokines may play a crucial role in IBD severity or other IBD related outcomes. Further studies are recommended to confirm the results.

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Acknowledgment

The authors wish to acknowledge Ms. Niloofar Shiva for critical editing of English grammar and syntax of the manuscript.

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Authors and Affiliations

  1. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, 7, West Arghavan St., Farahzadi Blvd., P.O. Box 19395-4741, 1981619573, Tehran, Iran

    Nava Morshedzadeh & Parvin Mirmiran

  2. Nutrition and Endocrine Research Center, Research Institute for Endocrine Science, Shahid Beheshti University of Medical Sciences, P.O. Box 19395-4763, Tehran, Iran

    Nava Morshedzadeh & Parvin Mirmiran

  3. Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Mehran Rahimlou

  4. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Hamid Asadzadeh Aghdaei, Shabnam Shahrokh & Mohammad Reza Zali

Authors
  1. Nava Morshedzadeh
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  2. Mehran Rahimlou
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  3. Hamid Asadzadeh Aghdaei
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  4. Shabnam Shahrokh
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  6. Parvin Mirmiran
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Corresponding author

Correspondence to Parvin Mirmiran.

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The authors declare no competing financial interests relevant to the present work.

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Morshedzadeh, N., Rahimlou, M., Asadzadeh Aghdaei, H. et al. Association Between Adipokines Levels with Inflammatory Bowel Disease (IBD): Systematic Reviews. Dig Dis Sci 62, 3280–3286 (2017). https://doi.org/10.1007/s10620-017-4806-5

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  • DOI: https://doi.org/10.1007/s10620-017-4806-5

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