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Esophageal Squamous Cell Carcinoma: Assessing Tumor Angiogenesis Using Multi-Slice CT Perfusion Imaging

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Abstract

Objectives

The purpose of this study was to investigate the correlation between multi-slice computed tomographic perfusion imaging (CTPI) parameters and immunohistologic markers of angiogenesis in esophageal squamous cell carcinoma (ESCC).

Methods

Fifty patients with histologically proven esophageal squamous cell carcinoma were enrolled in this study. All subjects underwent multi-slice CT perfusion scan. The hemodynamic parameters of vascular tumor, including blood volume (BV), blood flow (BF), mean transit time (MTT) and permeability surface (PS) were generated. All the ESCC specimens were stained immunohistochemically to identify CD31 for quantification of microvessel density (MVD). CTPI parameters were correlated with MVD by using Pearson correlation analysis.

Results

The value of CT perfusion parameters of ESCC were as follows: BF 116.71 ± 47.59 ml/100 g/min, BV 6.74 ± 2.70 ml/100 g, MTT 6.42 ± 2.84 s, PS 13.82 ± 6.25 ml/100 g/min. The mean MVD of all 50 tumor specimens was 34.44 ± 19.75. The PS values were significantly higher in ESCC patients with involvement of lymph node than those without involvement of lymph node (p < 0.01). Blood volume and permeability surface were positively correlated with MVD (p < 0.01), whereas no significant correlation was observed between MVD and BF or between MVD and MTT.

Conclusions

Blood volume and permeability surface were positively correlated with MVD. CTPI could reflect the angiogenesis in ESCC.

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Acknowledgments

We acknowledge Kui-Shen Chen (Department of Pathology, the First Affiliated Hospital of Zhengzhou University) for helpful discussions concerning the manuscript. We acknowledge Jian-Bo Gao (the First Affiliated Hospital of Zhengzhou University) for technical assistance.

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Radiology, Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450000, Henan, People’s Republic of China

    Tao Song, Hong-Tao Hu, Jin-Rong Qu, Xue-Jun Chen & Hai-Liang Li

  2. Department of Thoracic Surgery, Tianjin Chest Hospital, Tianjin Medical University, Xi’an Road, Tianjin, 300051, People’s Republic of China

    Xun Zhang

  3. Department of Nursing, Medical College of Shihezi University, Shihezi City, Xinjiang Uygur Autonomous Region, 832003, People’s Republic of China

    Na-Na Jiao & Xin-Hui Li

  4. Department of Pathology, Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, 450000, People’s Republic of China

    Wen Feng

  5. Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China

    Yu-Guang Shen

Authors
  1. Tao Song
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  2. Yu-Guang Shen
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  3. Na-Na Jiao
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  4. Xin-Hui Li
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  7. Xue-Jun Chen
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  8. Wen Feng
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  9. Xun Zhang
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  10. Hai-Liang Li
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Corresponding authors

Correspondence to Xun Zhang or Hai-Liang Li.

Additional information

Tao Song, Yu-Guang Shen, and Na-Na Jiao are co-first authors and contributed equally to this work.

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Song, T., Shen, YG., Jiao, NN. et al. Esophageal Squamous Cell Carcinoma: Assessing Tumor Angiogenesis Using Multi-Slice CT Perfusion Imaging. Dig Dis Sci 57, 2195–2202 (2012). https://doi.org/10.1007/s10620-012-2149-9

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  • DOI: https://doi.org/10.1007/s10620-012-2149-9

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