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Higher Prevalence of Obesity in Gastric Cardia Adenocarcinoma Compared to Gastric Non-Cardia Adenocarcinoma

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An Erratum to this article was published on 30 May 2012

Abstract

Background and Aims

Obesity is one of the main risk factors for gastric cardia adenocarcinoma (GCA) in the West. Also, recent studies have suggested that GCA is distinct from distal stomach tumor, with differing risk factors, tumor characteristics, and biological behavior. The objective of our research was to evaluate the relationship between obesity and GCA compared to non-cardia adenocarcinoma.

Materials and Methods

A total of 298 patients who were diagnosed with gastric adenocarcinoma and underwent surgery at Seoul National University Bundang Hospital were evaluated. Ninety-one cases were GCA, and 207 cases were non-cardiac adenocarcinoma. Obesity was estimated by body mass index (BMI, kg/m2). The degree of obesity was determined by using BMI <18.5, 18.5–23.9, 24–27.9, and ≥28 (kg/m2) as the cut-off points for underweight, normal weight, overweight, and obese, respectively. Association with obesity was estimated by odds ratio (OR) and 95% confidence interval (CI).

Results

Obesity was more prevalent in patients with GCA at the time of diagnosis for gastric cancer. Among obese persons with a BMI of 28 kg/m2 or higher, the OR was 3.937 (95% CI, 1.492–10.389; p = 0.006) for GCA compared to non-cardia adenocarcinoma. For overweight individuals, the OR was 2.194 (95% CI, 1.118–4.305; p = 0.022). Multivariate analysis of age, Helicobacter pylori infection, smoking, stage, and BMI with logistic regression was performed. BMI was an independent risk factor for GCA (OR, 1.123; 95% CI, 1.037–1.217; p = 0.004).

Conclusion

Obesity was more prevalent in patients with GCA compared to that in patients with gastric non-cardia adenocarcinoma. Also, BMI was an independent risk factor for GCA.

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Author notes

  1. Yuri Cho

    Present address: , Hanshin 19th apartment, Jamwon-dong, Seocho-gu, Seoul, 331-404, Korea

Authors and Affiliations

  1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

    Yuri Cho, Hong Sang Oh, Ji Yeon Seo, Dong Hyeon Lee, Hyun Chae Jung, Yong Bum Yoon & In Sung Song

  2. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea

    Dong Ho Lee, Nayoung Kim, Sook Hyang Jeong, Jin Wook Kim, Jin Hyuk Hwang, Young Soo Park, Sang Hyub Lee, Cheol Min Shin & Hyun Jin Jo

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  1. Yuri Cho
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Correspondence to Yuri Cho.

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Cho, Y., Lee, D.H., Oh, H.S. et al. Higher Prevalence of Obesity in Gastric Cardia Adenocarcinoma Compared to Gastric Non-Cardia Adenocarcinoma. Dig Dis Sci 57, 2687–2692 (2012). https://doi.org/10.1007/s10620-012-2095-6

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  • DOI: https://doi.org/10.1007/s10620-012-2095-6

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