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The Use of Self-Expanding Stents in Esophageal and Gastroesophageal Junction Cancer Palliation: A Meta-Analysis and Meta-Regression Analysis of Outcomes

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Abstract

Background

The objective of this study was to examine the impact of self-expanding stents versus locoregional treatment modalities in the setting of esophageal cancer palliation.

Methods

The present meta-analysis pooled the effects of outcomes of 1,027 patients enrolled in 16 randomized controlled trials.

Results

The meta-analysis revealed an advantage to the use of stents compared to locoregional modality treatments with respect to the number of patients requiring reinterventions, although the latter treatment arm had a higher 1-year survival. No difference was observed between the use of the antireflux stents and conventional stents in relieving reflux. Previous chemoradiotherapy had no impact on complications, procedural deaths, and overall patient survival. Differences in outcomes among stents were minimal.

Conclusions

Conventional self-expanding stents and anti-reflux stents are equally effective. Although the risk difference for 1-year survival favoured locoregional palliative treatment modalities, the latter were associated with a higher number of patients requiring reintervention.

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Acknowledgments

We are indebted to the authors of the primary studies.

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Authors and Affiliations

  1. 2nd Surgical Department and Surgical Oncology Unit, “Korgialenio–Benakio” Red Cross Hospital, 11 Mantzarou Str., Neo Psychiko, Athens, 15451, Greece

    George Sgourakis, Georgia Dedemadi, Konstantinos Goumas, Sofia Mylona & Constantine Karaliotas

  2. Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital, Mainz, Germany

    George Sgourakis, Ines Gockel, Arnold Radtke & Hauke Lang

  3. Department of Colorectal and Laparoscopic Surgery, James Paget University Hospital, Norfolk, UK

    Achilleas Tsiamis

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  1. George Sgourakis
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  2. Ines Gockel
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Correspondence to George Sgourakis.

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Sgourakis, G., Gockel, I., Radtke, A. et al. The Use of Self-Expanding Stents in Esophageal and Gastroesophageal Junction Cancer Palliation: A Meta-Analysis and Meta-Regression Analysis of Outcomes. Dig Dis Sci 55, 3018–3030 (2010). https://doi.org/10.1007/s10620-010-1250-1

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  • DOI: https://doi.org/10.1007/s10620-010-1250-1

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