Abstract
Crohn’s disease is considered to be caused either by an excess of T-cell effector functions and/or by a defective regulatory T-cell compartment. The aim of this study was to assess in Crohn’s disease the frequency of circulating CD4+CD25high T cells that possess regulatory T-cell functions and CD4+CD25low T cells that contain activated T cells. Flow cytometry of peripheral blood was used to assess CD4+CD25high and CD4+CD25low T-cell frequencies in a cohort of 66 patients with Crohn’s disease in comparison to 19 patients with ulcerative colitis and 31 healthy individuals enrolled as controls. The CD4+CD25high T-cell frequency was significantly lowered in naïve Crohn’s disease (P = 0.013) and in ulcerative colitis (P = 0.001). CD4+CD25low T-cell frequency was increased in Crohn’s disease (P = 0.0001) and in ulcerative colitis (P = 0.0002). Both CD4+CD25high and CD4+CD25low T-cell frequencies are altered in naïve Crohn’s disease resulting in an imbalance between both populations and a relative contraction of the CD4+CD25high T-cell population.
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Part of this work was financed by the French Centre National de la Recherche Scientifique (CNRS) and supported by the Strasbourg University Hospital.
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Chamouard, P., Monneaux, F., Richert, Z. et al. Diminution of Circulating CD4+CD25high T Cells in Naïve Crohn’s Disease. Dig Dis Sci 54, 2084–2093 (2009). https://doi.org/10.1007/s10620-008-0590-6
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DOI: https://doi.org/10.1007/s10620-008-0590-6