Abstract
Capsule endoscopy (CE) is a noninvasive imaging method used to evaluate intestinal mucosa. We aimed to examine intestinal mucosal changes in celiac disease (CD) with CE. Eight untreated patients who had anti-endomysial antibody-positive duodenal biopsy results consistent with CD were included in the study. Villous atrophy, scalloping, fissuring, and mosaic pattern (consistent with CD) were detected in seven patients; one patient was excluded for early meal consumption. No patchy involvement was found in the intestine or distal region of the intestine (ileum) in any of the patients. The common feature of all patients was that villous atrophy, scalloping, fissuring, and mosaic patterns detected in the proximal intestine gradually decreased towards the distal intestine. CE provided no diagnostic contribution to CD when compared with duodenal biopsy. It can be used to show villous atrophy in selected cases and to evaluate the extension of intestinal involvement in CD.
Similar content being viewed by others
References
Farrell RJ, Kelly CP (2002) Celiac sprue and refractory sprue. In: Feldman M, Friedman LS, Sleisinger MH (eds) Sleisenger and Fordtran’s gastrointestinal and liver disease, 7th edn. WB Saunders, Philadelphia, pp 1817–1841
Rewers M (2005) Epidemiology of celiac disease: what are the prevalence, incidence, and progression of celiac disease? Gastroenterology 128:S47–S51. doi:10.1053/j.gastro.2005.02.030
Hill ID (2005) What are the sensitivity and the specificity of the serologic tests for celiac disease? Do sensitivity and specificity vary in different populations? Gastroenterology 128:S25–S32. doi:10.1053/j.gastro.2005.02.012
Rostom A, Dubé C, Cranney A et al (2005) The diagnostic accuracy of serologic tests for celiac disease: a systematic review. Gastroenterology 128:S38–S46. doi:10.1053/j.gastro.2005.02.028
Oberhuber G, Granditsch G, Vogelsang H (1999) The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol 11:1185–1194. doi:10.1097/00042737-199910000-00019
Marsh MN (1992) Gluten major histocompatibility and the small intestine. A molecular and immunobiological approach to the spectrum of gluten sensitivity. Gastroenterology 102:330–354
Liangpunsakul S, Maglinte DD, Rex DK (2004) Comparison of wireless capsule endoscopy and conventional radiologic methods in the diagnosis of small bowel disease. Gastrointest Endosc Clin N Am 14:43–50. doi:10.1016/j.giec.2003.10.004
Costamagna G, Shah SK, Riccioni ME et al (2002) A prospective trial comparing small bowel radiographs and video capsule endoscopy for suspected small bowel disease. Gastroenterology 123:999–1005. doi:10.1053/gast.2002.35988
Remedios ML, Appleyard M (2005) Capsule endoscopy: current indications and future prospects. Intern Med J 35:234–239. doi:10.1111/j.1445-5994.2005.00808.x
Triester SL, Leighton JA, Leontiadis GI et al (2006) A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with non-stricturing small bowel Crohn’s disease. Am J Gastroenterol 101:954–964. doi:10.1111/j.1572-0241.2006.00506.x
Swain P (2005) Wireless capsule endoscopy and Crohn’s disease. Gut 54:323–326. doi:10.1136/gut.2004.047282
Ersoy O, Sivri B, Arslan S et al (2006) How much helpful is the capsule endoscopy for the diagnosis of small bowel lesions? World J Gastroenterol 28:3906–3910
Ersoy O, Sivri B, Bayraktar Y (2007) How helpful is capsule endoscopy to surgeons? World J Gastroenterol 13:3671–3676
Bayraktar Y, Ersoy O, Sokmensuer C (2007) The findings of capsule endoscopy in patients with common variable immunodeficiency syndrome. Hepatogastroenterology 54:1034–1037
Apostolopoulos P, Alexandrakis G, Giannakoulopoulou E et al (2004) M2A wireless capsule endoscopy for diagnosing ulcerative jejunoileitis complicating celiac disease. Endoscopy 36:247. doi:10.1055/s-2004-814259
Petroniene R, Dubcenco E, Baker JP et al (2005) Given capsule endoscopy in celiac disease: evaluation of diagnostic accuracy and interobserver agreement. Am J Gastroenterol 100:685–694. doi:10.1111/j.1572-0241.2005.41069.x
Culliford A, Daly J, Diamond B, Rubin M, Green PH (2005) The value of wireless capsule endoscopy in patients with complicated celiac disease. Gastrointest Endosc 62:55–61. doi:10.1016/S0016-5107(05)01566-X
Kesari A, Bobba RK, Arsura EL (2005) Video capsule endoscopy and celiac disease. Gastrointest Endosc 62:796–797. doi:10.1016/j.gie.2005.06.022
Daum S, Wahnschaffe U, Glasenapp R et al (2007) Capsule endoscopy in refractory celiac disease. Endoscopy 39:455–458. doi:10.1055/s-2007-966239
Hopper AD, Sidhu R, Hurlstone DP et al (2007) Capsule endoscopy: an alternative to duodenal biopsy for the recognition of villous atrophy in coeliac disease? Dig Liver Dis 39:140–145. doi:10.1016/j.dld.2006.07.017
Rondonotti E, Spada C, Cave D et al (2007) Video capsule enteroscopy in the diagnosis of celiac disease: a multicenter study. Am J Gastroenterol 102:1624–1631. doi:10.1111/j.1572-0241.2007.01238.x
Brocchi E, Corazza GR, Caletti G et al (1988) Endoscopic demonstration of loss of duodenal folds in the diagnosis of celiac disease. N Engl J Med 319:741–744
Jabbari M, Wild G, Goresky CA et al (1988) Scalloped valvulae conniventes: an endoscopic marker of celiac sprue. Gastroenterology 95:1518–1522
Siegel LM, Stevens PD, Lightdale CJ et al (1997) Combined magnification endoscopy with chromoendoscopy in the evaluation of patients with suspected malabsorption. Gastrointest Endosc 46:226–230. doi:10.1016/S0016-5107(97)70091-9
Smith AD, Graham I, Rose JD (1998) A prospective endoscopic study of scalloped folds and grooves in the mucosa of the duodenum as signs of villous atrophy. Gastrointest Endosc 47:461–465. doi:10.1016/S0016-5107(98)70245-7
Niveloni S, Fiorini A, Dezi R et al (1998) Usefulness of videoduodenoscopy and vital dye staining as indicators of mucosal atrophy of celiac disease: assessment of interobserver agreement. Gastrointest Endosc 47:223–229. doi:10.1016/S0016-5107(98)70317-7
Brocchi E, Corazza GR, Brusco G et al (1996) Unsuspected celiac disease diagnosed by endoscopic visualization of duodenal bulb micronodules. Gastrointest Endosc 44:610–611. doi:10.1016/S0016-5107(96)70020-2
Lee SK, Green PHR (2005) Endoscopy in celiac disease. Curr Opin Gastroenterol 21:589–594. doi:10.1097/01.mog.0000174218.00333.19
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ersoy, O., Akin, E., Ugras, S. et al. Capsule Endoscopy Findings in Celiac Disease. Dig Dis Sci 54, 825–829 (2009). https://doi.org/10.1007/s10620-008-0402-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10620-008-0402-z