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A Glass of Water Immediately Increases Gastric pH in Healthy Subjects

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Abstract

Onset of action of antisecretory agents is of pivotal importance for patients with gastroesophageal reflux disease (GERD) treated “on-demand.” Aim To study the acute effect of acid-inhibiting drugs and water administration on gastric pH. Method A cross-over study was performed in 12 H. pylori (-), healthy subjects (6 men; mean age: 26 years). A single oral dose of the following agents was received with a wash-out period between each study: a glass of water (200 ml), antacid, ranitidine, omeprazole, esomeprazole, and rabeprazole. Gastric pH was recorded for 6 h after drug intake. Results Water increased gastric pH >4 in 10/12 subjects after 1 min. The time (median) needed to pH >4 was for: antacid 2 min, ranitidine 50 min, omeprazole 171 min, esomeprazole 151 min, and rabeprazole 175 min. Gastric pH >4 lasted for 3 min after water and for 12 min after antacids; it remained >4 until the end of recording in: 4/12 subjects with ranitidine, 11/12 with rabeprazole, and all with omeprazole and esomeprazole. Conclusion Water and antacid immediately increased gastric pH, while PPIs showed a delayed but prolonged effect compared to ranitidine.

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Authors and Affiliations

  1. Hepatogastroenteroly Unit, 2nd Department of Internal Medicine-Propaedeutic, “Attikon” University General Hospital, Athens University, Athens, Greece

    George Karamanolis, Ioanna Theofanidou, Marina Yiasemidou, Evangelos Giannoulis & Konstantinos Triantafyllou

  2. Hepatogastroenteroly Unit, First Department of Internal Medicine-Propaedeutic, “Laikon” General Hospital, Athens University, Ag. Thoma 17, 11527, Athens, Greece

    Spiros D. Ladas

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  1. George Karamanolis
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  2. Ioanna Theofanidou
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  3. Marina Yiasemidou
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  4. Evangelos Giannoulis
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  5. Konstantinos Triantafyllou
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  6. Spiros D. Ladas
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Correspondence to Spiros D. Ladas.

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Karamanolis, G., Theofanidou, I., Yiasemidou, M. et al. A Glass of Water Immediately Increases Gastric pH in Healthy Subjects. Dig Dis Sci 53, 3128–3132 (2008). https://doi.org/10.1007/s10620-008-0301-3

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  • DOI: https://doi.org/10.1007/s10620-008-0301-3

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