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It Is Possible to Classify Non-erosive Reflux Disease (NERD) Patients into Endoscopically Normal Groups and Minimal Change Groups by Subjective Symptoms and Responsiveness to Rabeprazole—A Report from a Study with Japanese Patients

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An Erratum to this article was published on 02 December 2008

Abstract

The hypothesis that non-erosive reflux disease (NERD) patients comprise various subgroups is gaining popularity. This study was conducted to investigate the possibility of categorizing NERD patients according to symptom types and response to acid-suppressive drug rabeprazole (RPZ) 10 mg/day. NERD patients were classified as grade N (endoscopically normal), M (minimal change), or erosive GERD, and answered a 51-item, yes-or-no questionnaire pre and post-treatment. Compared to erosive GERD, clear differences existed in pretreatment prevalence of symptoms and responsiveness to RPZ in grades N and M; the results suggested stomachaches (especially at night) were significant symptoms in grade N and dysmotility-like symptoms like bloated stomach were significant in grade M while gastroesophageal reflux symptoms were significant in erosive GERD. Clinical significance of classifying NERD was indicated from different symptoms and responsiveness to PPI.

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Acknowledgments

The study was supported by an unrestricted grant from Eisai Co., Ltd.

Author information

Authors and Affiliations

  1. Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, 3-39-15 Showamachi, Maebashi, Gunma, 371-8511, Japan

    Motoyasu Kusano

  2. Department of Gastroenterology, Enshu Hospital, Hamamatsu, Japan

    Naohito Shirai

  3. Department of Internal Medicine, Saga Medical School, Saga, Japan

    Kanako Yamaguchi

  4. Departments of Comprehensive Medicine and Psychosomatic Medicine, Tohoku University Hospital, Sendai, Japan

    Michio Hongo

  5. Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Tsutomu Chiba

  6. Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, Japan

    Yoshikazu Kinoshita

Authors
  1. Motoyasu Kusano
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  2. Naohito Shirai
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  3. Kanako Yamaguchi
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  4. Michio Hongo
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  5. Tsutomu Chiba
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  6. Yoshikazu Kinoshita
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Consortia

The Acid-Related Symptom (ARS) Research Group

Corresponding author

Correspondence to Motoyasu Kusano.

Additional information

The authors of The Acid-Related Symptom (ARS) Research Group are given in Appendix I.

An erratum to this article can be found at http://dx.doi.org/10.1007/s10620-008-0636-9

Appendix I

Appendix I

The Acid-Related Symptom (ARS) Research Group consisted of the following investigators:

Yoshikazu Kinoshita::

Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, Japan.

Michio Hongo::

Departments of Comprehensive Medicine and Psychosomatic Medicine, Tohoku University Hospital, Sendai, Japan.

Tsutomu Chiba::

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Shuichi Ohara::

Health Administration Center, Department of Gastroenterology, Tohoku University Hospital, Sendai, Japan.

Motoyasu Kusano::

Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Maebashi, Japan.

Yoshio Hoshihara::

Clinic of the Ministry of Economy, Trade and Industry, Tokyo, Japan.

Susumu Kurosawa::

The First Department of Internal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.

Yusuke Watanabe::

Department of Otorhinolaryngology, International University of Health and Welfare Mita Hospital, Tokyo, Japan.

Takahisa Furuta::

Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Takashi Joh::

Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Kazuhide Higuchi::

Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan.

Yasuhiro Fujiwara::

Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Yasuki Habu::

Department of Gastroenterology, Saiseikai Noe Hospital, Osaka, Japan.

Hiroto Miwa::

Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

Ken Haruma::

Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan.

Noriaki Manabe::

Division of Endoscopy and Ultrasonography, Kawasaki Medical School, Kurashiki, Japan.

Kyoichi Adachi::

Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, Japan.

Tomohiko Shimatani::

Faculty of Nursing, Department of Nursing, Hiroshima International University, Kure, Japan.

Masanori Ito::

Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan.

Kazuma Fujimoto::

Department of Internal Medicine, Saga Medical School, Saga, Japan.

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Kusano, M., Shirai, N., Yamaguchi, K. et al. It Is Possible to Classify Non-erosive Reflux Disease (NERD) Patients into Endoscopically Normal Groups and Minimal Change Groups by Subjective Symptoms and Responsiveness to Rabeprazole—A Report from a Study with Japanese Patients. Dig Dis Sci 53, 3082–3094 (2008). https://doi.org/10.1007/s10620-008-0290-2

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  • DOI: https://doi.org/10.1007/s10620-008-0290-2

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