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Sarcoidosis in Patients with Celiac Disease

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Abstract

Purpose Several case reports and European studies have suggested an association between sarcoidosis and celiac disease; however, they have been inconsistent. We therefore analyzed a large cohort of celiac-disease patients to assess this association. Methods An anonymized database of patients with celiac disease was reviewed to determine the number of patients with sarcoidosis. Age- and gender-adjusted standardized morbidity ratios with corresponding 95% confidence intervals (CI) were calculated by comparing results to US-population-derived prevalence data. Results Ten patients were found to have a comorbid diagnosis of sarcoidosis, representing an age- and gender-adjusted standardized morbidity ratio of 36.8 (95% CI 26.7–50.9). Conclusions In this cohort of patients with celiac disease, there was a significantly increased risk of sarcoidosis when compared with the American white population. This further strengthens prior associations that have been made suggesting a shared mechanism behind the etiologies of celiac disease and sarcoidosis.

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Authors and Affiliations

  1. Department of Medicine, Columbia University Medical Center, 180 Fort Washington Avenue, Room 956, New York, NY, 10032, USA

    Elizabeth Hwang & Peter H. R. Green

  2. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA

    Russell McBride & Alfred I. Neugut

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  1. Elizabeth Hwang
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  2. Russell McBride
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  3. Alfred I. Neugut
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  4. Peter H. R. Green
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Correspondence to Peter H. R. Green.

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Hwang, E., McBride, R., Neugut, A.I. et al. Sarcoidosis in Patients with Celiac Disease. Dig Dis Sci 53, 977–981 (2008). https://doi.org/10.1007/s10620-007-9974-2

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  • DOI: https://doi.org/10.1007/s10620-007-9974-2

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