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Tanshinone IIA Ameliorates Trinitrobenzene Sulfonic Acid (TNBS)-Induced Murine Colitis

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An Erratum to this article was published on 21 January 2012

Abstract

Inflammatory bowel diseases are characterized by proinflammatory cytokines, oxidative stress, and tissue damage. Recently, tanshinone had been shown to act as an antioxidant, and to have anti-inflammatory bioactivity. The study was carried out to investigate the effect of tanshinone IIA on the inflammatory response of experimental colitis. Murine colitis was induced by trinitrobenzene sulfonic acid (TNBS). Ten or 20 mg tanshinone IIA was administrated to mice 4 h before the induction of colitis, and repeated daily until the mice were sacrificed. Colonic inflammation was examined by histological analysis, myeloperoxidase (MPO) activity, and the production of proinflammatory cytokines in colonic tissue. Activation of nuclear factor-kappa B was identified by western blot and immunohistochemistry, and oxidative stress was shown by glutathione (GSH) level in tissue. The mice with colitis treated by tanshinone IIA showed less tissue damage, lower MPO activity, less production of TNF-α and IL-1β, a higher level of GSH in colonic tissue, and downregulated activation of nuclear factor-kappa B in lamina propria mononuclear cells, compared with those of the untreated colitis group. Our data indicates that tanshinone IIA inhibits inflammatory response of colitis by downregulating the production of proinflammatory cytokines, and attenuating oxidative stress, which suggests that tanshinone IIA may be a new potential management for inflammatory bowel diseases.

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Authors and Affiliations

  1. Department of Gastroenterology, The First Affiliated Hospital, Nanchang University, Nanchang City, 330006, China

    Aiping Bai & Nonghua Lu

  2. Department of Pharmacy, The First Affiliated Hospital, Nanchang University, Nanchang City, 330006, China

    Yuan Guo

  3. Department of Medicine, The Affiliated Hospital, Luzhou Medical College, Luzhou City, 646000, China

    Xianmin Fan

Authors
  1. Aiping Bai
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  2. Nonghua Lu
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  3. Yuan Guo
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  4. Xianmin Fan
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Corresponding author

Correspondence to Aiping Bai.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s10620-012-2060-4

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Bai, A., Lu, N., Guo, Y. et al. Tanshinone IIA Ameliorates Trinitrobenzene Sulfonic Acid (TNBS)-Induced Murine Colitis. Dig Dis Sci 53, 421–428 (2008). https://doi.org/10.1007/s10620-007-9863-8

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  • DOI: https://doi.org/10.1007/s10620-007-9863-8

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