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Simvastatin Attenuates Trinitrobenzene Sulfonic Acid-Induced Colitis, but Not Oxazalone-Induced Colitis

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Abstract

Purpose To determine whether simvastatin is able to inhibit inflammation in trinitrobenzene sulfonic acid (TNBS)-induced or oxazalone (OXA)-induced colitis. Results In the prophylactic protocol, simvastatin dose-dependently suppressed the decrease in body weight and inflammatory grade of TNBS-treated mice. In contrast, in the therapeutic protocol, no significant difference in body weight reduction was observed between simvastatin-treated and control mice. IFN-γ release from LP cells was significantly suppressed in mice receiving high-dose simvastatin in the prophylactic protocol. In contrast to TNBS colitis, even high-dose prophylactic simvastatin had no suppressive effects on either weight reduction or the inflammatory grade in OXA colitis. Conclusion Our results indicate that simvastatin negatively regulates inflammation in TNBS-induced colitis, but not in OXA-induced colitis. In TNBS-induced colitis, simvastatin suppressed the Th1-polarized immune response. Our findings suggest that simvastatin has potential effects as a therapeutic agent in human inflammatory bowel disease, particularly Crohn’s disease.

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Acknowledgment

We would like to thank Merck & Co., Inc., for providing simvastatin.

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Authors and Affiliations

  1. Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan

    Maho Ikeda, Hajime Isomoto, Saburo Shikuwa, Yohei Mizuta & Shigeru Kohno

  2. Department of General Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Fuminao Takeshima & Yoshiyuki Ozono

Authors
  1. Maho Ikeda
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  2. Fuminao Takeshima
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  3. Hajime Isomoto
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  4. Saburo Shikuwa
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  5. Yohei Mizuta
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  6. Yoshiyuki Ozono
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  7. Shigeru Kohno
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Correspondence to Fuminao Takeshima.

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Ikeda, M., Takeshima, F., Isomoto, H. et al. Simvastatin Attenuates Trinitrobenzene Sulfonic Acid-Induced Colitis, but Not Oxazalone-Induced Colitis. Dig Dis Sci 53, 1869–1875 (2008). https://doi.org/10.1007/s10620-007-0102-0

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  • DOI: https://doi.org/10.1007/s10620-007-0102-0

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