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Anti-Inflammatory Effects of Pravastatin on Helicobacter Pylori-Induced Gastritis in Mice

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Abstract

Pravastatin, an HMG-CoA reductase inhibitor, exerts anti-inflammatory effects via several mechanisms including induction of endothelial nitric oxide synthase (eNOS). We investigated the effect of pravastatin on Helicobacter pylori-induced gastritis in mice. Mice with or without H. pylori infection received intraperitoneal pravastatin daily for 1 week. Expression of eNOS mRNA and tumor necrosis factor-α mRNA and myeloperoxidase activity in gastric tissue was determined. Myeloperoxidase activity was reduced in a dose-dependent manner by pravastatin, with activity inhibited by 53.5 and 73.7% at doses of 0.3 and 1 mg/kg, respectively. At a dose of 1 mg/kg, pravastatin reduced the level of tumor necrosis factor-α mRNA by 52.7%, while it did not affect eNOS expression. Pravastatin had no effects on these inflammatory parameters in uninfected mice. Pravastatin did not affect the viability of H. pylori. In conclusion, pravastatin exerts an anti-inflammatory effect on H. pylori-induced gastritis in mice without affecting eNOS expression.

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Authors and Affiliations

  1. Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan

    Masanori Yamato, Toshio Watanabe, Kazuhide Higuchi, Koichi Taira, Tetsuya Tanigawa, Masatsugu Shiba, Kazunari Tominaga, Yasuhiro Fujiwara, Nobuhide Oshitani & Tetsuo Arakawa

  2. Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan

    Masanori Yamato & Koji Takeuchi

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  1. Masanori Yamato
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  2. Toshio Watanabe
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  3. Kazuhide Higuchi
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Correspondence to Toshio Watanabe.

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Yamato, M., Watanabe, T., Higuchi, K. et al. Anti-Inflammatory Effects of Pravastatin on Helicobacter Pylori-Induced Gastritis in Mice. Dig Dis Sci 52, 2833–2839 (2007). https://doi.org/10.1007/s10620-006-9638-7

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  • DOI: https://doi.org/10.1007/s10620-006-9638-7

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