Skip to main content
SpringerLink
Log in

Minocycline Toxicity Requiring Liver Transplant

  • Case Report
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Ostapowicz G, Fontana RJ, Schiodt FV, Larson A, Davern TJ, Han SH, McCashland TM, Shakil AO, Hay JE, Hynan L, Crippin JS, Blei AT, Samuel G, Reisch J, Lee WM (2002) Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 17:947–954

    Google Scholar 

  2. Maddrey WC (2005) Drug-induced hepatotoxicity. J Clin Gastroenterol 39(Suppl 2):S83–S89

    Article  PubMed  Google Scholar 

  3. Kaufmann D, Pichler W, Beer JH (1994) Severe episode of high fever with rash, lymphadenopathy, neutropenia, and eosinophilia after minocycline therapy for acne. Arch Intern Med 12:1983–1984

    Article  Google Scholar 

  4. Kiessling S, Forrest K, Moscow J, Gewirtz A, Jackson E, Roszman T, Goebel J (2001) Interstitial nephritis, hepatic failure, and systemic eosinophilia after minocycline treatment. Am J Kidney Dis 38:E36

    PubMed  CAS  Google Scholar 

  5. Min DI, Burke PA, Lewis WD, Jenkins RL (1992) Acute hepatic failure associated with oral minocycline: a case report. Pharmacotherapy 12:68–71

    PubMed  CAS  Google Scholar 

  6. Knowles SR, Shapiro L, Shear NH (1996) Serious adverse reactions induced by minocycline: report of 13 patients and review of the literature. Arch Dermatol 132:934–939.

    Article  PubMed  CAS  Google Scholar 

  7. Shapiro LE, Knowles SR, Shear NH (1997) Comparative safety of tetracycline, minocycline, and doxycycline. Arch Dermatol 133:1224–1230

    Article  PubMed  CAS  Google Scholar 

  8. Roca B, Calvo B, Ferrer D (2003) Minocycline hypersensitivity reaction with acute respiratory distress syndrome. Intensive Care Med 29:338

    PubMed  Google Scholar 

  9. Sapadin AN, Fleischmajer R (2006) Tetracyclines: nonantibiotic properties and their clinical implications. J Am Acad Dermatol 54:258–265

    Article  PubMed  Google Scholar 

  10. Elkayam O, Yaron M, Caspi D (1999) Minocycline-induced autoimmune syndromes: an overview. Semin Arthritis Rheum 28:392–397

    Article  PubMed  CAS  Google Scholar 

  11. Pohle T, Menzel J, Domschke W (2000) Minocycline and fulminant hepatic failure necessitation liver transplantation. Am J Gastroenterol 95:560–561

    PubMed  CAS  Google Scholar 

  12. Thiim M, Friedman LS (2003) Hepatotoxicity of antibiotics and antifungals. Clin Liver Dis 7:381–399

    Article  PubMed  Google Scholar 

  13. Boudreaux JP, Hayes DH, Mizrahi S, Hussey J, Regenstein F, Balart L (1993) Fulminant hepatic failure, hepatorenal syndrome, and necrotizing pancreatitis after minocycline hepatotoxicity. Transplant Proc 25:1873

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, University of Chicago, Chicago, IL, USA

    Jennifer M. Holder-Murray, Emily B. Ahmed, Adam B. Cochrane, Giuliano Testa & J. Michael Millis

  2. Department of Surgery, Wayne State University and John D. Dingell VAMC, Suite 400, 4160 John R, Detroit, MI, 48201, USA

    Julian E. Losanoff

Authors
  1. Julian E. Losanoff
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jennifer M. Holder-Murray
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Emily B. Ahmed
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Adam B. Cochrane
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Giuliano Testa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. Michael Millis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Julian E. Losanoff.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Losanoff, J.E., Holder-Murray, J.M., Ahmed, E.B. et al. Minocycline Toxicity Requiring Liver Transplant. Dig Dis Sci 52, 3242–3244 (2007). https://doi.org/10.1007/s10620-006-9550-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-006-9550-1

Keywords

Search

Navigation