Abstract
We conducted a study to examine the relation of asthma and its treatment to irritable bowel syndrome (IBS). We identified cohorts of members with and without asthma from January 1996 though June 2002 and calculated rates of IBS in both cohorts. In a nested case-control study, we calculated odds ratios for oral steroid dispensings before IBS onset. To address differential IBS detection, we conducted a quantitative sensitivity analysis. We identified 91,237 people with asthma and sample of 24,518 people without asthma. There was a 20% increase in the incidence of IBS among people with asthma (standardized morbidity ratio = 1.2; 95% CI, 1.0–1.5), and no association between oral steroids and IBS among people with asthma (OR = 1.0; 95% CI, 0.9–1.1.) Misclassification of IBS would have biased the rate ratio toward the null. We observed a small increase in IBS among people with asthma, and no association between oral steroids and IBS onset among asthma patients.
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Busse WW, Lemanske RF Jr (2001) Asthma. N Engl J Med 344(5):350–362
Goldman L, Ausiello D (2004) Cecil textbook of medicine, 22nd ed. W. B. Saunders, Philadelphia, PA
Rhodes L, Moorman JE, Redd SC, Mannino DM (2003) Self-reported asthma prevalence and control among adults—United States, 2001. MMWR 52(17):381–384
Mannino DM, Homa DM, Pertowski CA, et al (1998) Surveillance for Asthma—United States, 1960–1995. MMWR 47(SS-1):1–28
Mannino DM, Homa DM, Akinbami LJ, Moorman JE, Gwynn C, Redd SC (2002) Surveillance for asthma—United States, 1980–1999. MMWR 51(SS-01):1–13
Horwitz BJ, Fisher RS (2001) The irritable bowel syndrome. N Engl J Med 344(24):1846–1850
Drossman DA, Camilleri M, Mayer EA, Whitehead WE (2002) AGA technical review on irritable bowel syndrome. Gastroenterology 123(6):2108–2131
Rome II diagnostic criteria for the functional gastrointestinal disorders. Degnon Associates
Kennedy TM, Jones RH, Hungin AP, O’Flanagan H, Kelly P (1998) Irritable bowel syndrome, gastro-oesophageal reflux, and bronchial hyper-responsiveness in the general population. Gut 43(6):770–774
White AM, Stevens WH, Upton AR, O’Byrne PM, Collins SM (1991) Airway responsiveness to inhaled methacholine in patients with irritable bowel syndrome. Gastroenterology 100(1):68–74
Huerta C, Garcia Rodriguez LA, Wallander M, Johansson S (2002) Risk of irritable bowel syndrome among asthma patients. Pharmacoepidemiol Drug Saf 11:31–35
Riccioni G, Della Vecchia R, Menna V, et al (2004) Irritable bowel syndrome and bronchial hyperresponsiveness: Is there a link? Digestion 69(3):185–189
International classification of diseases, 9th rev. (2001) Clinical modification. Medicode Publications, Salt Lake City, UT
Miettinen OS, Cook EF (1981) Confounding: essence and detection. Am J Epidemiol 114(4):593–603
Greenland S (1996) Basic methods for sensitivity analysis of biases. Int J Epidemiol 25(6):1107–1116
Huerta C, Garcia Rodriguez LA, Wallander M, Johansson S (2003) Users of oral steroids are at a reduced risk of developing irritable bowel syndrome. Pharmacoepidemiol Drug Saf 12:583–588
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Cole, J.A., Rothman, K.J., Cabral, H.J. et al. Incidence of IBS in a Cohort of People with Asthma. Dig Dis Sci 52, 329–335 (2007). https://doi.org/10.1007/s10620-006-9530-5
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DOI: https://doi.org/10.1007/s10620-006-9530-5