Skip to main content

Advertisement

SpringerLink
Log in

Hepatolithiasis and Cholangiocarcinoma in Cystic Fibrosis: A Case Series and Review of the Literature

  • Case Report
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Cystic Fibrosis Foundation (1998) Patient registry 1998 annual report. CFF, Bethesda, MD

  2. Sokol RJ, Durie PR (1999) Recommendations for management of liver and biliary tract disease in cystic fibrosis. Cystic Fibrosis Foundation Hepatobiliary Disease Consensus Group. J Pediatr Gastroenterol Nutr 28(Suppl 1):S1–S13

    Article  PubMed  Google Scholar 

  3. Konikoff F, Alcalay J, Halevy J (1986) Cloxacillin-induced cholestatic jaundice. Am J Gastroenterol 81(11):1082–1083

    PubMed  CAS  Google Scholar 

  4. Oppenheimer EH, Esterly JR (1975) Hepatic changes in young infants with cystic fibrosis: possible relation to focal biliary cirrhosis. J Pediatr 86(5):683–689

    Article  PubMed  CAS  Google Scholar 

  5. Nagel RA, Westaby D, Javaid A, et al. (1989) Liver disease and bile duct abnormalities in adults with cystic fibrosis. Lancet 2(8677):1422–1425

    Article  PubMed  CAS  Google Scholar 

  6. Stern RC, Rothstein FC, Doershuk CF (1986) Treatment and prognosis of symptomatic gallbladder disease in patients with cystic fibrosis. J Pediatr Gastroenterol Nutr 5(1):35–40

    Article  PubMed  CAS  Google Scholar 

  7. Magruder MJ, Munden MM (1997) Intrahepatic microlithiasis: another gastrointestinal complication of cystic fibrosis. J Ultrasound Med 16(11):763–765

    PubMed  CAS  Google Scholar 

  8. Durieu I, Pellet O, Simonot L, et al. (1999) Sclerosing cholangitis in adults with cystic fibrosis: a magnetic resonance cholangiographic prospective study. J Hepatol 30(6):1052–1056

    Article  PubMed  CAS  Google Scholar 

  9. Enriquez G, Lucaya J, Allende E, Garcia-Pena P (1992) Intrahepatic biliary stones in children. Pediatr Radiol 22(4):283–286

    Article  PubMed  CAS  Google Scholar 

  10. Bass S, Connon JJ, Ho CS (1983) Biliary tree in cystic fibrosis. Biliary tract abnormalities in cystic fibrosis demonstrated by endoscopic retrograde cholangiography. Gastroenterology 84(6):1592–1596

    PubMed  CAS  Google Scholar 

  11. Decarie JC, Garel L, Lacaille F (1990) Multiple intrahepatic stones in cystic fibrosis; a case report. Pediatr Radiol 20:412 (abstract)

    Google Scholar 

  12. Goriup U, Rickham PP, Deyhle P, Shmerling DH (1980) [Cholelithiasis as the first manifestation of cystic fibrosis of the pancreas (mucoviscidosis)]. Helv Paediatr Acta 35(2):177–184

    PubMed  CAS  Google Scholar 

  13. Park RW, Grand RJ (1981) Gastrointestinal manifestations of cystic fibrosis: a review. Gastroenterology 81(6):1143–1161

    PubMed  CAS  Google Scholar 

  14. Baldwin TL, Schutz SM, Owens G, Olivier K, Little C, Abbott R (1999) Successful endoscopic therapy of cholangitis associated with intrahepatic cholangiectasis in adult cystic fibrosis. Gastrointest Endosc 49(2):249–251

    Article  PubMed  CAS  Google Scholar 

  15. Tesluk H, McCauley K, Kurland G, Ruebner BH (1991) Cholangiocarcinoma in an adult with cystic fibrosis. J Clin Gastroenterol 13(4):485–487

    Article  PubMed  CAS  Google Scholar 

  16. Riordan JR, Rommens JM, Kerem B, et al. (1989) Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245(4922):1066–1073

    Article  PubMed  CAS  Google Scholar 

  17. Welsh MJRB, Accurso F, Cutting GR (2001) Cystic fibrosis. In: Scriver CL BA, Sly WS, Valle D (eds) The metabolic basis of inherited disease, 8th ed. McGraw–Hill, New York, pp 5121–5188

    Google Scholar 

  18. Strazzabosco M, Spirli C, Okolicsanyi L (2000) Pathophysiology of the intrahepatic biliary epithelium. J Gastroenterol Hepatol 15(3):244–253

    Article  PubMed  CAS  Google Scholar 

  19. Colombo C, Crosignani A, Battezzati PM (1999) Liver involvement in cystic fibrosis. J Hepatol 31(5):946–954

    Article  PubMed  CAS  Google Scholar 

  20. Dodd GD 3rd, Niedzwiecki GA, Campbell WL, Baron RL (1997) Bile duct calculi in patients with primary sclerosing cholangitis. Radiology 203(2):443–447

    PubMed  Google Scholar 

  21. McEvoy CF, Suchy FJ (1996) Biliary tract disease in children. Pediatr Clin North Am 43(1):75–98

    Article  PubMed  CAS  Google Scholar 

  22. Maki T (1966) Pathogenesis of calcium bilirubinate gallstones: role of E. coli, B-glucuronidase and coagulation by inorganic ions, polyelectrolytes, and agitation. Ann Surg 164:90–100

    Article  PubMed  CAS  Google Scholar 

  23. Masuda H, Nakayama F (1979) Composition of bile pigment in gallstones and bile and their etiological significance. J Lab Clin Med 93(3):353–360

    PubMed  CAS  Google Scholar 

  24. Chen MF, Jan YY, Wang CS, et al. (1993) A reappraisal of cholangiocarcinoma in patient with hepatolithiasis. Cancer 71(8):2461–2465

    Article  PubMed  CAS  Google Scholar 

  25. Yoshimoto H, Ikeda S, Tanaka M, Matsumoto S (1985) Intrahepatic cholangiocarcinoma associated with hepatolithiasis. Gastrointest Endosc 31(4):260–263

    PubMed  CAS  Google Scholar 

  26. Lim JH (1991) Oriental cholangiohepatitis: pathologic, clinical, and radiologic features. AJR Am J Roentgenol 157(1):1–8

    PubMed  CAS  Google Scholar 

  27. Matsushiro T (1965) Identification of glucaro-1,4-lactone in bile as an essential factor in inhibitory effect of bile upon bacterial beta-glucuronidase activity. Tohoku J Exp Med 85:330–339

    Article  PubMed  CAS  Google Scholar 

  28. Matsushiro T, Suzuki N, Sato T, Maki T (1977) Effects of diet on glucaric acid concentration in bile and the formation of calcium bilirubinate gallstones. Gastroenterology 72(4; Pt 1):630–633

    PubMed  CAS  Google Scholar 

  29. de Almeida AM, Cruz AG, Aldeia FJ (1984) Side-to-side choledochoduodenostomy in the management of choledocholithiasis and associated disease. Facts and fiction. Am J Surg 147(2):253–259

    CAS  Google Scholar 

  30. Sung JY, Leung JW, Shaffer EA, Lam K, Olson ME, Costerton JW (1992) Ascending infection of the biliary tract after surgical sphincterotomy and biliary stenting. J Gastroenterol Hepatol 7(3):240–245

    PubMed  CAS  Google Scholar 

  31. Duthie A, Doherty DG, Williams C, et al. (1992) Genotype analysis for delta F508, G551D and R553X mutations in children and young adults with cystic fibrosis with and without chronic liver disease. Hepatology 15(4):660–664

    Article  PubMed  CAS  Google Scholar 

  32. Kinnman N, Lindblad A, Housset C, et al. (2000) Expression of cystic fibrosis transmembrane conductance regulator in liver tissue from patients with cystic fibrosis. Hepatology 32(2):334–340

    Article  PubMed  CAS  Google Scholar 

  33. Westaby D (1995) Liver and biliary disease in cystic fibrosis. In: Hodson ME, Geddes DM (eds) Cystic fibrosis. Chapman and Hall, London, pp 281–293

    Google Scholar 

  34. Lindblad A, Hultcrantz R, Strandvik B (1992) Bile-duct destruction and collagen deposition: a prominent ultrastructural feature of the liver in cystic fibrosis. Hepatology 16(2):372–381

    Article  PubMed  CAS  Google Scholar 

  35. Abdul-Karim FW, King TA, Dahms BB, Gauderer MW, Boat TF (1982) Carcinoma of extrahepatic biliary system in an adult with cystic fibrosis. Gastroenterology 82(4):758–762

    PubMed  CAS  Google Scholar 

  36. Koga A, Ichimiya H, Yamaguchi K, Miyazaki K, Nakayama F (1985) Hepatolithiasis associated with cholangiocarcinoma. Possible etiologic significance. Cancer 55(12):2826–2829

    CAS  Google Scholar 

  37. Sheen-Chen SM, Chou FF, Eng HL (1991) Intrahepatic cholangiocarcinoma in hepatolithiasis: A frequently overlooked disease. J Surg Oncol 47(2):131–135

    Article  PubMed  CAS  Google Scholar 

  38. Chijiiwa K, Ichimiya H, Kuroki S, Koga A, Nakayama F (1993) Late development of cholangiocarcinoma after the treatment of hepatolithiasis. Surg Gynecol Obstet 177:279–282

    PubMed  CAS  Google Scholar 

  39. Falchuk KR, Lesser PB, Galdabini JJ, Isselbacher KJ (1976) Cholangiocarcinoma as related to chronic intrahepatic cholangitis and hepatolithiasis. Case report and review of the literature. Am J Gastroenterol 66(1):57–61

    CAS  Google Scholar 

  40. Chen MF, Jan YY, Wang CS, Jeng LB, Hwang TL, Chen SC (1989) Intrahepatic stones associated with cholangiocarcinoma. Am J Gastroenterol 84:391–395

    PubMed  CAS  Google Scholar 

  41. Calvo MM, Bujanda L, Calderon A, et al. (2002) Role of magnetic resonance cholangiopancreatography in patients with suspected choledocholithiasis. Mayo Clin Proc 77(5):422–428

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA

    David G. Perdue, Oliver W. Cass & Jordan Dunitz

  2. Department of Pediatrics, University of Minnesota, 420 Delaware Street, MMC 185, Minneapolis, Minnesota, 55455, USA

    Carlos Milla, Harvey L. Sharp & Sarah J. Schwarzenberg

  3. Department of Pathology, University of Minnesota, Minneapolis, Minnesota, USA

    Jose Jessurun

  4. The Minnesota Cystic Fibrosis Center, 420 Delaware Street, MMC 185, Minneapolis, Minnesota, 55455, USA

    Carlos Milla, Jordan Dunitz & Sarah J. Schwarzenberg

Authors
  1. David G. Perdue
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Oliver W. Cass
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carlos Milla
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jordan Dunitz
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jose Jessurun
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Harvey L. Sharp
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Sarah J. Schwarzenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sarah J. Schwarzenberg.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Perdue, D.G., Cass, O.W., Milla, C. et al. Hepatolithiasis and Cholangiocarcinoma in Cystic Fibrosis: A Case Series and Review of the Literature. Dig Dis Sci 52, 2638–2642 (2007). https://doi.org/10.1007/s10620-006-9259-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-006-9259-1

Keywords

Search

Navigation