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Usefulness of Serum Pepsinogens in Helicobacter pylori Chronic Gastritis: Relationship With Inflammation, Activity, and Density of the Bacterium

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Abstract

We sought to study the relationship between serum pepsinogens and different histopathologic features of Helicobacter pylori-related chronic gastritis. One hundred forty-nine consecutive dyspeptic patients underwent endoscopy with biopsies; serum pepsinogens I and II were measured by immunoassay. Serum levels of pepsinogens (sPG) were significantly correlated with H. pylori density both of the corpus (sPGI: r = 0.32, P < .001; sPGII: r = 0.56, P < .001) and antrum (sPGI: r = 0.41, P < .001; sPGII: r = 0.43, P < .001) as well as with chronic inflammation (sPGI: r = 0.26, P < .001; sPGII: r = 0.49, P < .001) and activity (sPGI: r = 0.38, P < .001; sPGII: r = 0.50, P < .001) in the antrum. Only sPGII was correlated with chronic inflammation (r = 0.44, P < .001) and activity (r = 0.40, P < .001) in the corpus. SPGI was inversely correlated with atrophy (r = –0.33, P < .001) and intestinal metaplasia (r = –0.37, P < .001) in the corpus. sPGII levels could be considered as markers of gastric inflammation all over in the stomach. sPGI levels are inversely related to atrophic body gastritis.

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Authors and Affiliations

  1. Chair of Gastroenterology, Department of Clinical Sciences, University of Parma, Via Gramsci 14, 43100, Parma, Italy

    Francesco Di Mario, Lucas Giovanni Cavallaro, Ali Mahamat Moussa, Roberta Merli, Andrea Maini, Simone Bertolini, Giulia Martina Cavestro, Giovanni Aragona & Mario Plebani

  2. Pathologic Institute, University of Parma, Parma, Italy

    Pietro Caruana

  3. Gastroenterology Unit, Hospital of Treviso, Treviso, Italy

    Nadia Dal Bó

  4. Department of Pathology, University Hospital of Padova, Padova, Italy

    Massimo Rugge

  5. Department of Laboratory Medicine, Laboratory Medicine, University Hospital of Padova, Padova, Italy

    Mario Plebani

  6. Gastroenterology Unit, Hospital of Parma, Parma, Italy

    Angelo Franzé & Giorgio Nervi

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  1. Francesco Di Mario
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  2. Lucas Giovanni Cavallaro
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  3. Ali Mahamat Moussa
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Correspondence to Francesco Di Mario.

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Di Mario, F., Cavallaro, L.G., Moussa, A.M. et al. Usefulness of Serum Pepsinogens in Helicobacter pylori Chronic Gastritis: Relationship With Inflammation, Activity, and Density of the Bacterium. Dig Dis Sci 51, 1791–1795 (2006). https://doi.org/10.1007/s10620-006-9206-1

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  • DOI: https://doi.org/10.1007/s10620-006-9206-1

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