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Relationships Between Intragastric Food Maldistribution, Disturbances of Antral Contractility, and Symptoms in Functional Dyspepsia

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Abstract

We investigated the relationships between intragastric food maldistribution and antral dysmotility in functional dyspepsia, and whether these abnormalities relate to meal-induced symptoms. Intragastric distribution of food throughout gastric emptying was determined in patients (n = 24) and controls (n = 38) after a liquid nutrient meal labeled with 99mtechnetium phytate. Antral contractility was also periodically assessed by dynamic scintigraphy and postprandial symptoms were monitored with visual analog scales. Residence of food in the proximal stomach was decreased in 8 (33%) and antral contractility was increased in 9 (37.5%) and decreased in 2 (8%) patients. Proximal and distal stomach motor abnormalities were neither significantly correlated nor associated. Increased antral contractility was significantly correlated (Rs = 0.54; P < .01) with postprandial nausea. We conclude that diminished residence of food in the proximal stomach and disturbed antral contractility occur independently in different subsets of functional dyspepsia patients. Increased antral contractility seems to play a role in postprandial nausea in functional dyspepsia.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Medicine, Ribeirão Preto FacultMedicine, University of São Paulo, Campus of Ribeirão Preto, São Paulo, Brazil

    Luiz E. A. Troncon PhD, MD (Professor), José Ruver Herculano JR, MD, PhD, Roberta D. Savoldelli MD, Marie Secaf & Ricardo B. Oliveira MD, PhD

  2. Department of Physics and Mathematics, Ribeirão Preto School of Sciences (FFCLRP-USP), University of São Paulo, Campus of Ribeirão Preto, São Paulo, Brazil

    Eder R. Moraes Phd, MD

  3. Depto. Clínica Médica, Hospital das Clínicas, Campus da USP, CEP: 14048-900, Ribeirão Preto, State of São Paulo, Brazil

    Luiz E. A. Troncon PhD, MD (Professor)

Authors
  1. Luiz E. A. Troncon PhD, MD
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  2. José Ruver Herculano JR, MD, PhD
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  3. Roberta D. Savoldelli MD
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  4. Eder R. Moraes Phd, MD
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  5. Marie Secaf
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  6. Ricardo B. Oliveira MD, PhD
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Correspondence to Luiz E. A. Troncon PhD, MD.

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Troncon, L.E.A., Herculano, J.R., Savoldelli, R.D. et al. Relationships Between Intragastric Food Maldistribution, Disturbances of Antral Contractility, and Symptoms in Functional Dyspepsia. Dig Dis Sci 51, 517–526 (2006). https://doi.org/10.1007/s10620-006-3164-5

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  • DOI: https://doi.org/10.1007/s10620-006-3164-5

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