Skip to main content

Advertisement

SpringerLink
Log in

Hepatitis C Virus Genotype 5 in Southern Belgium: Epidemiological Characteristics and Response to Therapy

  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Data are scarce on patients infected with hepatitis C virus of genotype 5, due to the low prevalence of this genotype around the world. To better define the characteristics of these patients, we reviewed the files of 16 genotype 5 patients. Mean age was 38 ± 14. All patients were of European origin. Most of them (75%) had been contaminated by transfusion within a short time period (between 1980 and 1991). There were no intravenous drug addicts. Seven patients received treatment. One patient did not respond to interferon (IFN) monotherapy. Of four patients treated with IFN and ribavirin, three became sustained viral responders. Two patients treated with pegylated IFN and ribavirin became sustained viral responders. In our region, genotype 5 patients seem to have been contaminated within a relatively short time period. Treatment with IFN or pegylated IFN and ribavirin gave a high rate (83%) of sustained viral responses.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Zein N: Clinical significance of hepatitis C virus genotypes. Clin Microbiol Rev 13(2):223–235, 2000

    Article  CAS  PubMed  Google Scholar 

  2. Davidson F, Simmonds P, Ferguson J, Jarvis L, Dow B, Follet E, Seed C, Krusius T, Lin C, Medgyesi G, Kiyokawa H, Olim G, Duraisamy G, Cypers T, Saeed A, Teo D, Conradie J, Kew M, Lin M, Nuchaprayoon C, Ndimbie O, Yap P : Survey of major genotypes and subtypes of hepatitis C virus using RFLP of sequences amplified from the 5′ non-coding region. J Gen Virol 76:1197–1204, 1995

    Article  CAS  PubMed  Google Scholar 

  3. Simmonds P: Variability of hepatitis C virus. Hepatology 21(2):570–581, 1995

    Article  CAS  PubMed  Google Scholar 

  4. Blatt L, Mutchnick M, Tong M, Klion F, Lebovics E, Freilich B, Bach N, Smith C, Herrera J, Tobias H, Conrad A, Schmid P, Mc Hutchison J: Assessment of hepatitis C virus RNA and genotype from 6807 patients with chronic hepatitis C in the United States. J Viral Hepatol 7:196–202, 2000

    Article  CAS  Google Scholar 

  5. Ross R, Viazov S, Renzing-Kohler K, Roggendorf M: Changes in the epidemiology of hepatitis C infection in Germany: shift in the predominance of hepatitis C subtypes. J Med Virol 60:122–125, 2000

    Article  CAS  PubMed  Google Scholar 

  6. Levi J, Takaoka D, Garrini R, Fachini R, Focaccia R, De Bortholi Santos E, Mitre H, De Mendonça J, De Paula Cavalheiro N, Barone A, Wendel S: Three cases of infection with hepatitis C virus genotypes 5 among Brazilian hepatitis patients. J Clin Microbiol 40:2645–2647, 2002

    CAS  PubMed  Google Scholar 

  7. Shobokshi O, Serebour F, Skakni L, Al-Saffy H, Ahdal M: Hepatitis C genotypes and subtypes in Saudi Arabia. J Med Virol 58:44–48, 1999

    Article  CAS  PubMed  Google Scholar 

  8. Legrand-Abravanel F, Sandrès-Sauné K, Barange K, Alric L, Moreau J, Desmorat P, Vinel J, Izopet J: Hepatitis C virus genotype 5: epidemiological characteristics and sensitivity to combination therapy with interferon-α plus ribavirin. J Infect Dis 189:1397–1400, 2004

    Article  CAS  PubMed  Google Scholar 

  9. Murphy DG, Willems B, Vincelette J, Bernier L, Cote J, Delage G: Biological and clinicopathological features associated with hepatitis C virus type 5 infections. J Hepatol 24:109–113, 1996

    Article  CAS  PubMed  Google Scholar 

  10. Jover R, Pérez-Serra J, De Vera F, Alamo J, Munoz C, Yago C, Martinez-Ramirez R, Vidal J: Infection by genotype 5a of HCV in a district of Southeast Spain. Am J Gastroenterol 96:3042–3043, 2001

    Article  CAS  PubMed  Google Scholar 

  11. Henquell C, Cartau C, Abergel A, Laurichesse H, Regagnon C, De Champs C, Bailly JL, Peigue-Lafeuille H: High prevalence of hepatitis C virus type 5 in Central France evidenced by a prospective study from 1996 to 2002. J Clin Microbiol 42(7):3030–3035, 2004

    Article  PubMed  Google Scholar 

  12. Chamberlain R, Adams N, Taylor L, Simmonds P, Elliott R: The complete coding sequence of hepatitis C virus genotype 5a, the predominant genotype in South Africa. Biochem Biophys Res Commun 236 (1):44–49, 1997

    Article  CAS  PubMed  Google Scholar 

  13. Strader D, Wright T, Thomas D, Seeff L: Diagnosis, management, and treatment of hepatitis C. AASLD practice guideline. Hepatology 39(4):1147–1171, 2004

    Article  PubMed  Google Scholar 

  14. Bedossa P, Poynard T: An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 24:289–293, 1996

    CAS  PubMed  Google Scholar 

  15. Imbert-Bismut F, Ratziu v, Pieroni L, Charlotte F, Benhamou Y, Poynard T: Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Lancet 357:1069–1075, 2001

    CAS  PubMed  Google Scholar 

  16. Bukh J, Apgar C, Engle R, Govindarajan S, Hegerich P, Tellier R, Wong D, Elkins R, Kew M: Experimental infection of chimpanzees with hepatitis C virus of genotype 5a: genetic analysis of the virus and generation of a standardized challenge pool. J Infect Dis 178(4):1193–1197, 1998

    CAS  PubMed  Google Scholar 

  17. Kedda M, Kew M, Coppi A: Hepatocarcinogenic potential of genotype 5 of hepatitis C virus. Trop. Gastroenterol 18:153–155, 1997

    CAS  PubMed  Google Scholar 

  18. Bonny C, Roche C, Randl K, Ughetto S, Henquell C, Martineau N, Fontaine H, Pol S, Lafeuille H, Bommelaer G, Abergel A: Treatment of interferon-naïve patients with HCV genotype 5 wiith interferon (or peginterferon) plus ribavirin results in a very high sustained viral response. Hepatology 38(4):A75, 2003

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hepato-Gastroenterology, Hospital Saint-Joseph, Liège

    Jean Delwaide MD, PhD (Dr.), Catherine Reenaers MD, Jacques Belaiche MD & Groupe Liegeois D'etudes Des Virus Hepatotropes

  2. Department of Immuno-Hematology, CHU Sart Tilman, Liège, Hospital Saint-Joseph, Liège, Belgium

    Christiane Gerard & Dolores Vaira

  3. Department of Gastroenterology, Hospital Saint-Joseph, Malmedy, Belgium

    Boris Bastens MD

  4. Department of Gastroenterology, CHR Huy, Huy, Hospital Malmedy, Malmedy, Belgium

    Christian Bataille MD

  5. Department of Gastroenterology, CHR Bois-Abbaye, Seraing, Hospital Malmedy, Malmedy, Belgium

    Benoit Servais MD

  6. Department of Gastroenterology, Hospital Malmedy, Malmedy, Belgium

    Bernard Maes MD

  7. Department of Hepato-Gastroenterology, CHU Sart Tilman, 4000, Liège, Belgium

    Jean Delwaide MD, PhD (Dr.)

Authors
  1. Jean Delwaide MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christiane Gerard
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Catherine Reenaers MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dolores Vaira
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Boris Bastens MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Christian Bataille MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Benoit Servais MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Bernard Maes MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Jacques Belaiche MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Groupe Liegeois D'etudes Des Virus Hepatotropes
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jean Delwaide MD, PhD.

Additional information

GLEVHE members are as follows: Hepato-Gastroenterology—J. Delwaide and J. Belaïche; Immuno-Hematology—G. Maggipinto and C. Gérard; Virology—D. Vaira and B. Rentier; Liver Surgery and Transplantation—A. De Roover, O. Detry, and P. Honoré.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Delwaide, J., Gerard, C., Reenaers, C. et al. Hepatitis C Virus Genotype 5 in Southern Belgium: Epidemiological Characteristics and Response to Therapy. Dig Dis Sci 50, 2348–2351 (2005). https://doi.org/10.1007/s10620-005-3060-4

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-005-3060-4

KeyWords

Search

Navigation