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Associated Factors in Modulating Aflatoxin B1–Albumin Adduct Level in Three Chinese Populations

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Abstract

To elucidate the potential factors modulating exposure to aflatoxin B1 (AFB1) in three Chinese populations, an epidemiologic study was conducted in Fusui County and Nanning City of Guangxi Province and Chengdu City of Sichuan Province. The incidence rates of hepatocelluar carcinoma (HCC) for males in these three regions were 92–97 per 100,000, 32–47 per 100,000, and 21 per 100,000, respectively. Eighty-nine residents from Fusui, 196 residents from Nanning, and 118 residents from Chengdu were screened for AFB1–albumin adduct (AAA) levels and hepatitis virus (HBV, HCV, HDV, HEV, and HGV) infections, as well as liver biochemistry (alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase [ALP], γ-glutamyl transpeptidase [GGT], 5′-nucleotidase, globulin [GLO], direct bilirubin, indirect bilirubin, and bile acid levels). At least one marker of hepatitis virus (HV) infection was present in 47.2% (42/89) of subjects from Fusui, while in Nanning and Chengdu the values were 15.8% (31/196) and 22.0% (26/118), respectively. In contrast to females, a higher level of AAA was observed in males; the difference was statistically significant in both the Nanning (P = 0.023) and the Chengdu (P = 0.026) subjects. In the Chengdu group, there was a significantly higher level of AAA in cases with HV infection (P = 0.041). There was a close association between AAA level and BMI in the adults without HV infection (r = 0.148, P = 0.044). Also, AAA was closely associated with DBIL and GGT in non-HV-infected minors (P < 0.05), closely associated with ALB, GLO, and GGT in HV-infected minors (P < 0.05), and closely associated with IBIL, GLO, TBA, and AST in non-HV-infected adults (P < 0.01). The co-effect of HV infection and AFB1 exposure may be responsible for the high risk of HCC in the Fusui region, whereas age, gender, BMI, and HV infection may modify individual aflatoxin levels. The relationship between AAA level and liver biochemistry indicates injury induced by aflatoxin to both hepatic parenchyma and biliary tract. But the associations vary with age and HV infection status.

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Authors and Affiliations

  1. Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province

    Peng Tao MD, Liu Zhi-Ming MD, Liu Tang-Wei MD, Li Le-Qun MD, Peng Min-Hao MD & Qin Xue MD

  2. Department of General Surgery, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan Province

    Yan Lu-Nam MD

  3. Fusui Cancer Research Institute, Fusui County, 532100, Guangxi Province, China

    Liang Ren-Xiang & Wei Zong-Liang

  4. Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, 10032, USA

    Wang Lian-Wen & Wang Qiao

  5. Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, 119260

    Shen Han-Ming PhD, Ong Choon-Nam PhD & Regina M. Santella PhD

  6. Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, 10032, USA

    Regina M. Santella PhD

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  1. Peng Tao MD
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Correspondence to Regina M. Santella PhD.

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Tao, P., Zhi-Ming, L., Tang-Wei, L. et al. Associated Factors in Modulating Aflatoxin B1–Albumin Adduct Level in Three Chinese Populations. Dig Dis Sci 50, 525–532 (2005). https://doi.org/10.1007/s10620-005-2468-1

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  • DOI: https://doi.org/10.1007/s10620-005-2468-1

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