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Synthesis and Cytotoxicity of 28-Oxo-Allobetulone Derivatives

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Chemistry of Natural Compounds Aims and scope

28-Oxo-allobetulone derivatives that were newly synthesized or prepared earlier by modification of ring A (3- and 4-pyridylidene, furfurylidene, azepane, lactam, quinolone, spiroindole, pyrazole, isoxazole, and tetraoxane derivatives) and 3β,19β,28-oleantriol were tested in vitro for cytotoxicity against 60 cell lines of 9 human tumor types. Melanoma SK-MEL-5 and CNS SNB-75 cancer cells died in the presence of 3- or 4-pyridylidene derivatives of 28-oxo-allobetulone. 3β,19β,28-Oleantriol possessed selective cytotoxicity against CNS cancer cell line SNB-75.

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Acknowledgment

The work was performed on State Task Topic No. AAAA-A17-117011910023-2. We thank the National Cancer Institute (NCI) for determining the in vitro antitumor activities of 2–16.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Federal Research Center, 71 Prosp. Oktyabrya, Ufa, 450054, Russia

    E. F. Khusnutdinova, I. E. Smirnova & O. B. Kazakova

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  1. E. F. Khusnutdinova
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  2. I. E. Smirnova
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  3. O. B. Kazakova
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Correspondence to O. B. Kazakova.

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Translated from Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2020, pp. 401–406.

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Khusnutdinova, E.F., Smirnova, I.E. & Kazakova, O.B. Synthesis and Cytotoxicity of 28-Oxo-Allobetulone Derivatives. Chem Nat Compd 56, 465–471 (2020). https://doi.org/10.1007/s10600-020-03064-5

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  • DOI: https://doi.org/10.1007/s10600-020-03064-5

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