Skip to main content
SpringerLink
Log in

New Iridoids from the Whole Plant of Patrinia heterophylla

  • Published:
Chemistry of Natural Compounds Aims and scope

Two new iridoids (1, 2), along with one known iridoid (3), two known triterpenoid saponins (4, 5), and one known flavonoid (6), were isolated from the whole plant of Patrinia heterophylla Bunge. Their structures were elucidated on the basis of extensive spectroscopic data analysis, especially by means of 1D and 2D NMR and HR-ESI-MS analyses. The cytotoxic activity of the isolated compounds against human leukemic cells was evaluated using CCK-8 assay. Compounds 1 and 2 showed cytotoxic activities against HL-60, K562, and Jurkat cells, and compounds 3 and 5 showed cytotoxic activity against HL-60. Among them, compound 1 showed slightly stronger cytotoxic activity against K562 cells than the positive control.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.

Similar content being viewed by others

References

  1. T. Zhang, Q. Li, K. Li, J. Li, G. Wang, and S. Zhou, Phytother. Res., 22, 640 (2008).

    Article  CAS  PubMed  Google Scholar 

  2. X. Wan, J. L. Shi, Y. Liu, and P. G. Xiao, World Phytomed., 21, 53 (2006).

    Google Scholar 

  3. Y. F. Li, F. C. Lou, Y. P. Tang, and J. H. Wang, Nat. Prod. Res. Dev., 13, 71 (2001).

    Google Scholar 

  4. B. Yang, R. B. Cheng, Y. Q. Wang, L. Shen, and R. S. Zhang, Nat. Prod. Res., 27, 2105 (2013).

    Article  CAS  PubMed  Google Scholar 

  5. P. W. Thies, Tetrahedron, 24, 313 (1968).

    Article  CAS  Google Scholar 

  6. U. Shinichi, S. Xie, I. Hiroyuki, S. Tetsuro, I. Masatoshi, and D. Mitsunobu, Phytochemistry, 26, 561 (1987).

    Article  Google Scholar 

  7. K. Sisido, K. Inomata, T. Kageyama, and K. Utimoto, J. Org. Chem., 33, 3149 (1968).

    Article  CAS  Google Scholar 

  8. Y. Zhang, Y. Lu, L. Zhang, Q. T. Zheng, L. Z. Xu, and S. L. Yang, J. Nat. Prod., 68, 1131 (2005).

    Article  CAS  PubMed  Google Scholar 

  9. S. M. Abdel Khalik, T. Miyase, H. A. El-Ashaal, and F. R. Melek, Phytochemistry, 54, 853 (2000).

    Article  CAS  PubMed  Google Scholar 

  10. C. N. Lin, Phytochemistry, 30, 3103 (1991).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgment

We are grateful to Ms. MeiFeng Xu and Ms. Qi Zhang for the NMR and HR-ESI-MS measurement in the Instrumentation Center of the Academy of Military Medical Sciences.

Author information

Authors and Affiliations

  1. Department of Clinical Pharmacology, PLA General Hospital, 100853, Beijing, P. R. China

    Li-Hua Mu, Li Liu & Ping Liu

  2. Department of Clinical Surgery, PLA General Hospital, 100853, Beijing, P. R. China

    Yu-Ning Wang

  3. Shanxi University of Chinese Traditional Medicine, 030024, Taiyuan, P. R. China

    Li Liu

Authors
  1. Li-Hua Mu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yu-Ning Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Li Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ping Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ping Liu.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2019, pp. 29–31.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mu, LH., Wang, YN., Liu, L. et al. New Iridoids from the Whole Plant of Patrinia heterophylla. Chem Nat Compd 55, 32–35 (2019). https://doi.org/10.1007/s10600-019-02609-7

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10600-019-02609-7

Keywords

Search

Navigation