Two new biflavonoids, sinodiflavonoids A (1) and B (2), were isolated from the roots and rhizomes of Sinopodophyllum emodi. Their structures were established on the basis of extensive spectroscopic evidences (HR-ESI-MS, 1H NMR, 13C NMR, HSQC, HMBC, CD). Their cytotoxic activities were evaluated in comparison with etoposide against four cell lines (MCF-7, HepG2, HeLa, KB). The preliminary structure–activity relationships showed that the simple, nonprenylated, nonmethylated biflavonoid (2) showed higher cytotoxic activities than the corresponding prenylated 3-hydroxymethylated one (1).
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Acknowledgment
This work was supported by the National Natural Science Foundation of China (No. 31300284), Basic Science Foundation of Henan University of Chinese Medicine (No. 2014KYYWF-QN26), Foundation of Henan Province for Excellent Young Teachers of Colleges and Universities (No. 2015GGJS-096), Doctoral Science Foundation of Henan University of Chinese Medicine (No. BSJJ2011-13), Science Innovation Talent of Henan University of Traditional Chinese Medicine (No. 2016XCXRC01), and Science Innovation Team of Henan University of Chinese Medicine (No. 2015XCXTD02).
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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2018, pp. 550–553.
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Sun, Y., Shi, B., Gao, M. et al. Two New Biflavonoids from the Roots and Rhizomes of Sinopodophyllum emodi. Chem Nat Compd 54, 649–653 (2018). https://doi.org/10.1007/s10600-018-2438-4
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DOI: https://doi.org/10.1007/s10600-018-2438-4