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The Alkaloidal Constituents of Cephalotaxus mannii Collected in Lam Dong Province, Vietnam

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Eight alkaloidal constituents have been isolated and structurally elucidated from Cephalotaxus mannii Hook. f. collected from the highland Lam Dong Province, Vietnam. They are: cephalotaxine (1), isoharringtonine (2), norisoharringtonine (3), desoxyharringtonine (4), nordesoxyharringtonine (5), cephalotaxine 𝛽 -N-oxide (6), 3-epi-schellhammericine (7), and an isomer of 3-epi-schellhammericine (8). Among them, norisoharringtonine (3) is a new compound, while the other compounds are isolated from C. mannii for the first time. The structures of these constituents were determined by spectroscopic methods such as FTIR, ESI-MS, HR-ESI-MS, and NMR (1D, 2D) and by comparison with published data.

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Acknowledgment

This work was supported by the Tay Nguyen III program (Project No. TN III-15). We are also grateful to Dr. Nguyen Tien Hiep, Institute of Ecology and Biological Ressources, VAST; M. Sci. Dang Vu Luong, and M. Sci. Ngo Van Quang for NMR and MS measurement.

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Authors and Affiliations

  1. Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay District, Hanoi, Vietnam

    Tran Van Loc, Tran Thi Phuong Thao, Nguyen Thi Luu, Ho Ngoc Anh, Le Thi Thu Ha, Tran Van Chien, Pham Thi Ninh & Tran Van Sung

  2. Hanoi University, 98 Duong Quang Ham, Hanoi, Vietnam

    Nguyen Thi Lieu

  3. Vietnam National Museum of Nature, VAST, 18 Hoang Quoc Viet, Cau Giay District, Hanoi, Vietnam

    Dinh Thi Phong

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  1. Tran Van Loc
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  2. Nguyen Thi Lieu
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  3. Tran Thi Phuong Thao
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Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2017, pp. 953–956.

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Van Loc, T., Lieu, N.T., Thao, T.T.P. et al. The Alkaloidal Constituents of Cephalotaxus mannii Collected in Lam Dong Province, Vietnam. Chem Nat Compd 53, 1122–1126 (2017). https://doi.org/10.1007/s10600-017-2214-x

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  • DOI: https://doi.org/10.1007/s10600-017-2214-x

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