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Novel Isoflavone from the Cockroach Periplaneta americana

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Chemistry of Natural Compounds Aims and scope

A novel compound, 13,13-dimethyl,12-(16-hydroxy,16,16-dimethyl)-propanol-∆11,12-hydrogenated pyranyl-7,8[benzo]-4′-methoxyisoflavone (1), together with two known insect secondary metabolites 2 and 3, was isolated from the 70% methanol extract of Periplaneta americana cockroaches. The structures of the isolated compounds were established by NMR spectroscopic and HR-ESI-MS analysis. Their antibacterial activities were determined by Kirby-Bauer disc diffusion antibiotic susceptibility testing. The results indicated that both isoflavone compounds 1 and 2 showed significant inhibitory effects against the Gram-positive bacterium B. subtilis with minimum inhibitory concentrations (MIC) values of 15 μg/mL.

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Acknowledgment

We are grateful for support from the National Natural Science Foundation of China (Grant No. 21472035).

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Authors and Affiliations

  1. School of Chemical Engineering and Pharmaceutics, Henan University of Science and Technology, 471023, Luoyang, Henan, P. R. China

    J. Y. Gao, Y. L. Jiang, L. L. Niu, H. D. Li & W. P. Yin

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  1. J. Y. Gao
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  2. Y. L. Jiang
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  3. L. L. Niu
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  4. H. D. Li
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  5. W. P. Yin
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Corresponding author

Correspondence to W. P. Yin.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2016, pp. 362–364.

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Gao, J.Y., Jiang, Y.L., Niu, L.L. et al. Novel Isoflavone from the Cockroach Periplaneta americana . Chem Nat Compd 52, 413–416 (2016). https://doi.org/10.1007/s10600-016-1661-0

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  • DOI: https://doi.org/10.1007/s10600-016-1661-0

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