New derivatives of betulin, betulinic acid methyl ester, and their acetate analogs containing 1,2,3-triazole fragments in the C-30 position were synthesized. It was shown using the Ames test that 30-azidolup-20(29)-enes and 3β,28-diacetoxy-30-(4-R-1,2,3-triazol-1-yl)lup-20(29)-enes did not exhibit mutagenic properties.
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Translated from Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2013, pp. 564–570.
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Antimonova, A.N., Petrenko, N.I., Shakirov, M.M. et al. Synthesis and study of mutagenic properties of lupane triterpenoids containing 1,2,3-triazole fragments in the C-30 position. Chem Nat Compd 49, 657–664 (2013). https://doi.org/10.1007/s10600-013-0702-1
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DOI: https://doi.org/10.1007/s10600-013-0702-1