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New cytotoxic spongian-class rearranged diterpenes from a marine sponge

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Chemistry of Natural Compounds Aims and scope

Chemical investigation of an Okinawan marine sponge resulted in the isolation of two new spongian-class diterpenes 1 and 2 together with two known compounds, chromodorolide B (3) and chromodorolide C (4). Compound 1, named chromodorolide D, is an example of a diterpenoid with a highly rearranged chromodorane carbon skeleton, while compound 2 retains the open side chains. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis and chemical conversion. Compounds 1–4 exhibited significant cytotoxicity against NBT-T2 rat bladder epithelial cells.

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Authors and Affiliations

  1. Department of Chemistry, University of Chittagong, 4331, Chittagong, Bangladesh

    Mohammad Helal Uddin & Mohammed Kamrul Hossain

  2. Department of Law, Premier University, 4203, Chittagong, Bangladesh

    Meher Nigar

  3. Okinawa Institute of Science and Technology (OIST), 12-22 Suzaki, Uruma, 904-2234, Okinawa, Japan

    Michael Chandro Roy

  4. Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, 903-0213, Okinawa, Japan

    Junichi Tanaka

Authors
  1. Mohammad Helal Uddin
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  2. Mohammed Kamrul Hossain
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  3. Meher Nigar
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  4. Michael Chandro Roy
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  5. Junichi Tanaka
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Correspondence to Mohammad Helal Uddin.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2012, pp. 373–375.

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Uddin, M.H., Hossain, M.K., Nigar, M. et al. New cytotoxic spongian-class rearranged diterpenes from a marine sponge. Chem Nat Compd 48, 412–415 (2012). https://doi.org/10.1007/s10600-012-0262-9

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  • DOI: https://doi.org/10.1007/s10600-012-0262-9

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