A new bicyclo[3.2.1]octanoid neolignan rel-(7S,8R,1′S,2′R,3′S)-Δ8′-2′-hydroxy-5,1′,3′-trimethoxy-3,4methylenedioxy-7,3′,8,1′-neolignan (1) was isolated from ethanol extract from the fruit of Ocotea heterochroma Mez & Sodiro ex Mez as well as the known compounds β-friedelanol (2), meso-dehydroguaiaretic acid (3), and yangambin (4), whose structures were elucidated on the basis of their comprehensive spectroscopic analysis including 2D NMR data. Lethality bioassay using brine shrimp (Artemia salina Leach) was evaluated with the ethanol extract from the Ocotea heterochroma’s fruit. The toxicity of this extract was greater than the toxicity of those fractions obtained in a first solvent partition (benzene, ethyl acetate, and butanol subfractions) and that of a mixture of acetylated 2′-epimers from the new neolignan 1.
Similar content being viewed by others
References
H. Lopez, A. Valera, and J. Trujillo, J. Nat. Prod., 58, 782 (1995).
A. Lacava and M. Yoshida, Phytochemistry, 46, 741 (1997).
J. Aiba, O. R. Gottlieb, M. Yoshida, J. Mourao, and E. Gottlieb, Phytochemistry, 15, 1031 (1975).
Q. Jesus-Morais, F. Assis, B. Cordeiro, M. Filho, W. Lima, L. Silva, T. Bozza, and C. Neto, Planta Med., 66, 211 (2000)
P. Romoff, M. Yoshida, and O. Gottlieb, Phytochemistry, 23, 2101 (1984).
G. Carvalho, M. Yoshida, O. Gottlieb, and E. Gottlieb, Phytochemistry, 27, 2319 (1988).
M. David, M. Yoshida, and O. Gottlieb, Phytochemistry, 36, 491 (1994).
J. McLaughlin, M. Rogers, and J. E. Anderson, Drug Inform. J., 32, 513 (1998).
Acknowledgment
We thank the Chemistry Department of Universidad Nacional de Colombia and Plant Natural Product Laboratory for financing this research and the Fundacion Instituto de Inmunologia de Colombia (FIDIC), Bogota, for taking the spectra records.
Author information
Authors and Affiliations
Corresponding author
Additional information
Published in Khimiya Prirodnykh Soedinenii, No. 2, pp. 158–160, March–April, 2009.
Rights and permissions
About this article
Cite this article
Cuca, L.E., Leon, P. & Coy, E.D. A bicyclo[3.2.1]octanoid neolignan and toxicity of the ethanol extract from the fruit of Ocotea heterochroma . Chem Nat Compd 45, 179–181 (2009). https://doi.org/10.1007/s10600-009-9304-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10600-009-9304-3