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Synthesis and characterization of new pyrido- and pyrazolopyrimidine derivatives using 2-substituted vinamidinium salts

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Chemistry of Heterocyclic Compounds Aims and scope

Several novel pyrido- and pyrazolopyrimidine derivatives were readily synthesized by reaction of 6-aminouracil or 3(5)-aminopyrazole with 2-substituted vinamidinium salts. The reactions were carried out in a relatively short time without any base or catalyst. The structures of the synthesized compounds were confirmed by UV-vis, IR, and 1H and 13C NMR spectroscopy, as well as mass spectrometry and elemental analysis. The obtained results showed that tautomers of 3(5)-amino-1(H)-pyrazole can participate in the formation of the new pyrido- and pyrazolopyrimidine derivatives with their respective most nucleophilic centers N-2 and C-4.

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Financial support of this work by the Research Council of the Persian Gulf University is gratefully acknowledged.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Sciences, Persian Gulf University, Bushehr, 75169, Iran

    Abdolmohammad Mehranpour, Sedigheh Hashemnia & Mona Bornak

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  1. Abdolmohammad Mehranpour
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  2. Sedigheh Hashemnia
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  3. Mona Bornak
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Correspondence to Abdolmohammad Mehranpour.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2019, 55(11), 1087–1091

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Mehranpour, A., Hashemnia, S. & Bornak, M. Synthesis and characterization of new pyrido- and pyrazolopyrimidine derivatives using 2-substituted vinamidinium salts. Chem Heterocycl Comp 55, 1087–1091 (2019). https://doi.org/10.1007/s10593-019-02582-7

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  • DOI: https://doi.org/10.1007/s10593-019-02582-7

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