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Synthesis and study of novel 1,2,4-triazolylacetic acid derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

A range of 1,2,4-triazolylacetic acids and their derivatives with various substituents at the triazole ring position 3 have been synthesized. The properties of the obtained compounds were studied, showing that: 1) triazolylacetic esters are strong acylating agents; 2) all the obtained triazolylacetic acids underwent decarboxylation when heated to the melting point; 3) the CH2 group in the acetyl moiety can react as methylene component in condensation reactions.

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  1. Kyiv Taras Shevchenko National University, 64 Volodymirska St., Kyiv, 01601, Ukraine

    Dmitro M. Khomenko, Roman O. Doroshchuk, Oleksandr V. Vashchenko & Rostyslav D. Lampeka

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  1. Dmitro M. Khomenko
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  2. Roman O. Doroshchuk
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Correspondence to Dmitro M. Khomenko.

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Khomenko, D.M., Doroshchuk, R.O., Vashchenko, O.V. et al. Synthesis and study of novel 1,2,4-triazolylacetic acid derivatives. Chem Heterocycl Comp 52, 402–408 (2016). https://doi.org/10.1007/s10593-016-1901-z

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  • DOI: https://doi.org/10.1007/s10593-016-1901-z

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