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Synthesis of 4H-thieno[3,2-c]chromenes by intramolecular arylation of 4-aryloxy-methyl-5-iodothiophene-2-carbaldehydes

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Chemistry of Heterocyclic Compounds Aims and scope

The iodination of 4-chloromethylthiophene-2-carbaldehyde by N-iodosuccinimide under solvent-free conditions gives 4-chloromethyl-5-iodothiophene-2-carbaldehyde, which is used to obtain 4-aryloxy-methyl-5-iodothiophene-2-carbaldehydes. The palladium-catalyzed intramolecular cyclization of 4-aryloxymethyl-5-iodothiophene-2-carbaldehydes yields 4H-thieno[3,2-c]chromene-2-carbaldehydes.

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Authors and Affiliations

  1. F. M. Dostoevskii Omsk State University, 55a Mira Ave., 644077, Omsk, Russia

    A. S. Fisyuk, Yu. P. Bogza, L. V. Belyaeva & V. B. Belyaev

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  1. A. S. Fisyuk
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  2. Yu. P. Bogza
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  3. L. V. Belyaeva
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  4. V. B. Belyaev
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Correspondence to A. S. Fisyuk.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1160-1166, July, 2012.

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Fisyuk, A.S., Bogza, Y.P., Belyaeva, L.V. et al. Synthesis of 4H-thieno[3,2-c]chromenes by intramolecular arylation of 4-aryloxy-methyl-5-iodothiophene-2-carbaldehydes. Chem Heterocycl Comp 48, 1078–1084 (2012). https://doi.org/10.1007/s10593-012-1102-3

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  • DOI: https://doi.org/10.1007/s10593-012-1102-3

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