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Fluorinated [1,2,4]triazolo[1,5-a]pyrimidines and [1,2,4]triazolo[5,1-c][1,2,4]triazines*

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Chemistry of Heterocyclic Compounds Aims and scope

The reaction of 3-R-5-amino-1,2,4-triazoles with the ethyl ester of 2-fluoroacetoacetic acid gave 2-R-fluoro[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-ones. The reaction of a 3-R-1,2,4-triazolyl-5-diazonium salt with the ethyl ester of 2-fluoroacetoacetic acid and subsequent cyclization of the triazolylhydrazones lead to 7-R-3-fluoro[1,2,4]triazolo[5,1-c][1,2,4]triazin-4(1H)-ones.

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Authors and Affiliations

  1. Ural Federal University, 19 Mira St., 620002, Yekaterinburg, Russia

    E. N. Ulomskiy, N. R. Medvedeva, A. V. Shchepochkin, O. S. Eltsov, V. L. Rusinov & O. N. Chupakhin

  2. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Akademicheskaya/S. Kovalevskaya St., Yekaterinburg, 620019, Russia

    V. L. Rusinov & O. N. Chupakhin

  3. Research Institute of Influenza, Russian Academy of Medical Sciences, 15/17 Prof. Popov St., St. Petersburg, 197376, Russia

    E. G. Deeva & O. I. Kiselev

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  1. E. N. Ulomskiy
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  2. N. R. Medvedeva
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  3. A. V. Shchepochkin
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  4. O. S. Eltsov
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  5. V. L. Rusinov
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  6. O. N. Chupakhin
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  7. E. G. Deeva
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  8. O. I. Kiselev
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Correspondence to E. N. Ulomskiy.

Additional information

*Dedicated to Academician V. N. Charushin on the occasion of his sixtieth birthday.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1411–1417, September, 2011.

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Ulomskiy, E.N., Medvedeva, N.R., Shchepochkin, A.V. et al. Fluorinated [1,2,4]triazolo[1,5-a]pyrimidines and [1,2,4]triazolo[5,1-c][1,2,4]triazines*. Chem Heterocycl Comp 47, 1164–1169 (2011). https://doi.org/10.1007/s10593-011-0887-9

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  • DOI: https://doi.org/10.1007/s10593-011-0887-9

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