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Preparation of N-phenyl-substituted quinolinium derivatives labeled with tritium by chemonuclear synthesis

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Chemistry of Heterocyclic Compounds Aims and scope

A chemonuclear method of synthesis is proposed for obtaining difficultly available phenyl-substituted derivatives of quinoline labeled with tritium. The ion-molecule reaction of free phenyl cations, generated on β-decay of tritium, with the nucleophilic centers of heterocyclic compounds is the basis of the synthesis. The onium derivatives synthesized possess significant inhibitory antimicrobial activity and are promising for a detailed study of the reaction mechanisms and metabolic processes using radioactive indicators.

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Authors and Affiliations

  1. Natural Sciences Institute, Perm State University, Perm, 614990, Russia

    N. E. Shchepina & G. A. Alexandrova

  2. Saint Petersburg State University, Saint Petersburg, 199034, Russia

    V. V. Avrorin

  3. M. V. Lomonosov Moscow State University, Moscow, 119991, Russia

    G. A. Badun & V. M. Fedoseev

  4. Perm State Technical University, Perm, 614600, Russia

    S. E. Ukhanov

  5. James Madison University, Harrisonburg, VA, USA

    S. B. Lewis

  6. “Tekhnolog”, Pereslavl-Zalessky, 152025, Yaroslavl region, Russia

    I. I. Boiko

Authors
  1. N. E. Shchepina
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  2. V. V. Avrorin
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  3. G. A. Badun
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  4. G. A. Alexandrova
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  5. S. E. Ukhanov
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  6. V. M. Fedoseev
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  7. S. B. Lewis
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  8. I. I. Boiko
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Correspondence to N. E. Shchepina.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1008-1014, July, 2009.

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Shchepina, N.E., Avrorin, V.V., Badun, G.A. et al. Preparation of N-phenyl-substituted quinolinium derivatives labeled with tritium by chemonuclear synthesis. Chem Heterocycl Comp 45, 796–801 (2009). https://doi.org/10.1007/s10593-009-0359-7

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  • DOI: https://doi.org/10.1007/s10593-009-0359-7

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