Abstract
The synthetic routes of 1,2,4-triazole compounds as well as their pharmacological properties have been described. The review focuses intensively on two methods: cycloaddition reaction in the syntheses of various 1,5-dialky-1H-1,2,4-triazole derivatives from the reactive cumulenes with the nitrile precursors as well as the microwave irradiation method.
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Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1605–1634, November, 2006.
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Al-Masoudi, I.A., Al-Soud, Y.A., Al-Salihi, N.J. et al. 1,2,4-Triazoles: Synthetic approaches and pharmacological importance. (Review). Chem Heterocycl Compd 42, 1377–1403 (2006). https://doi.org/10.1007/s10593-006-0255-3
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DOI: https://doi.org/10.1007/s10593-006-0255-3