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Frontiers of cancer imaging and guided therapy using ultrasound, light, and microwaves

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Abstract

This review describes emerging techniques within the last 5 years that employ ultrasound for detecting and staging malignancy, tracking metastasis, and guiding treatment. Ultrasound elastography quantifies soft tissue elastic properties that change as a tumor grows and proliferates. Hybrid imaging modalities that combine ultrasound with light or microwave energy provide novel contrast for mapping blood oxygen saturation, transport of particles through lymphatic vessels and nodes, and real-time feedback for guiding needle biopsies. Combining these methods with smart nanoparticles and contrast agents further promotes new paradigms for cancer imaging and therapy.

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References

  1. Barr RG, Destounis S, Lackey LB, Svensson WE, Balleyguier C, Smith C (2012) Evaluation of breast lesions using sonographic elasticity imaging: a multicenter trial. J Ultrasound Med 31(2):281–287

    Article  Google Scholar 

  2. Sayed A, Layne G, Abraham J, Mukdadi OM (2014) 3-D visualization and non-linear tissue classification of breast tumors using ultrasound elastography in vivo. Ultrasound Med Biol 40(7):1490–1502

    Article  Google Scholar 

  3. Yang Y, Xu X, Guo L, He Y, Wang D, Liu B, Zhao C, Chen B, Xu H (2017) Qualitative and quantitative analysis with a novel shear wave speed imaging for differential diagnosis of breast lesions. Sci Rep 7:40964

    Article  CAS  Google Scholar 

  4. Leemans CR, Tiwari R, Nauta JJ, van der Waal I, Snow GB (1993) Regional lymph node involvement and its significance in the development of distant metastases in head and neck carcinoma. Cancer 71(2):452–456

    Article  CAS  Google Scholar 

  5. Ho F, Tham IW, Earnest A, Lee KM, Lu JJ (2012) Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence. BMC Cancer 12:98

    Article  Google Scholar 

  6. Azizi G, Keller JM, Mayo ML, Piper K, Puett D, Earp KM, Malchoff CD (2016) Shear wave elastography and cervical lymph nodes: predicting malignancy. Ultrasound Med Biol 42(6):1273–1281

    Article  Google Scholar 

  7. Chen BB, Li J, Guan Y, Xiao WW, Zhao C, Lu TX, Han F (2018) The value of shear wave elastography in predicting for undiagnosed small cervical lymph node metastasis in nasopharyngeal carcinoma: a preliminary study. Eur J Radiol 103:19–24

    Article  Google Scholar 

  8. Ting CE, Yeong CH, Ng KH, Abdulla BJJ, Ting HE (2015) Accuracy of tissue elasticity measurement using shear wave ultrasound elastography: a comparative phantom study. In: World congress on medical physics and biomedical engineering. Springer, Toronto, pp 252–255

    Google Scholar 

  9. Menezes GLG, Pijnappel RM, Meeuwis C, Bisschops R, Veltman J, Lavin PT, van de Vijver MJ, Mann RM (2018) Downgrading of breast masses suspicious for cancer by using optoacoustic breast imaging. Radiology 17:170500

    Google Scholar 

  10. Lin L, Hu P, Shi J, Appleton CM, Maslov K, Li L, Zhang R, Wang LV (2018) Single-breath-hold photoacoustic computed tomography of the breast. Nat Commun 9(1):2352

    Article  Google Scholar 

  11. Garcia-Uribe A, Erpelding TN, Krumholz A, Ke H, Maslov K, Appleton C, Margenthaler JA, Wang LV (2015) Dual-modality photoacoustic and ultrasound imaging system for noninvasive sentinel lymph node detection in patients with breast cancer. Sci Rep 5:15748

    Article  CAS  Google Scholar 

  12. Forbrich A, Heinmiller A, Zemp RJ (2017) Photoacoustic imaging of lymphatic pumping. J Biomed Opt 22(10):106003

    Article  Google Scholar 

  13. Stoffels I, Morscher S, Helfrich I, Hillen U, Leyh J, Burton NC, Sardella TC, Claussen J, Poeppel TD, Bachmann HS, Roesch A, Griewank K, Schadendorf D, Gunzer M, Klode J (2015) Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging. Sci Transl Med 7(317):317ra199

    Article  Google Scholar 

  14. Luke GP, Myers JN, Emelianov SY, Sokolov KV (2014) Sentinel lymph node biopsy revisited: ultrasound-guided photoacoustic detection of micrometastases using molecularly targeted plasmonic nanosensors. Cancer Res 74(19):5397–5408

    Article  CAS  Google Scholar 

  15. Yang L, Cheng J, Chen Y, Yu S, Liu F, Sun Y, Chen Y, Ran H (2017) Phase-transition nanodroplets for real-time photoacoustic/ultrasound dual-modality imaging and photothermal therapy of sentinel lymph node in breast cancer. Sci Rep 7:45213

    Article  CAS  Google Scholar 

  16. Kruger RA, Miller KD, Reynolds HE, Kiser WL, Reinecke DR, Kruger GA (2000) Breast cancer in vivo: contrast enhancement with thermoacoustic CT at 434 MHz—feasibility study. Radiology 216(1):279–283

    Article  CAS  Google Scholar 

  17. Razansky D, Kellnberger S, Ntziachristos V (2010) Near-field radiofrequency thermoacoustic tomography with impulse excitation. Med Phys 37(9):4602–4607

    Article  Google Scholar 

  18. Lou C, Yang S, Ji Z, Chen Q, Xing D (2012) Ultrashort microwave-induced thermoacoustic imaging: a breakthrough in excitation efficiency and spatial resolution. Phys Rev Lett 109:218101

  19. Ye F, Ji Z, Ding W, Lou C, Yang S, Xing D (2016) Ultrashort microwave-pumped real-time thermoacoustic breast tumor imaging system. IEEE Trans Med Imaging 35(3):839–844

    Article  Google Scholar 

  20. Wen L, Yang S, Zhong J, Zhou Q, Xing D (2017) Thermoacoustic imaging and therapy guidance based on ultra short pulsed microwave pumped thermoelastic effect induced with superparamagnetic iron oxide nanoparticles. Theranostics 7(7):1976–1989

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, University of Arizona, Tucson, AZ, 85724, USA

    Russell S. Witte, Chandra Karunakaran, Andres N. Zuniga, Hannah Schmitz & Hina Arif

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  1. Russell S. Witte
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  2. Chandra Karunakaran
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  3. Andres N. Zuniga
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  4. Hannah Schmitz
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  5. Hina Arif
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Correspondence to Russell S. Witte.

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Witte, R.S., Karunakaran, C., Zuniga, A.N. et al. Frontiers of cancer imaging and guided therapy using ultrasound, light, and microwaves. Clin Exp Metastasis 35, 413–418 (2018). https://doi.org/10.1007/s10585-018-9923-9

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  • DOI: https://doi.org/10.1007/s10585-018-9923-9

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