Abstract
Long before the nervous system is organized into electrically active neural circuits, connectivity emerges between cells of the developing brain through extracellular signals. Extracellular vesicles that shuttle RNA, proteins, and lipids from donor cells to recipient cells are candidates for mediating connectivity in the brain. Despite the abundance of extracellular vesicles during brain development, evidence for their physiological functions is only beginning to materialize. Here, we review evidence of the existence, content, and functions of extracellular vesicles in brain development.
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This work is supported by a grant from the Whitehall Foundation to DMF.
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Mary C. Morton and David M. Feliciano declare that there are no conflicts of interest.
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Morton, M.C., Feliciano, D.M. Neurovesicles in Brain Development. Cell Mol Neurobiol 36, 409–416 (2016). https://doi.org/10.1007/s10571-015-0297-0
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DOI: https://doi.org/10.1007/s10571-015-0297-0