Abstract
MicroRNA is strongly associated with tumor growth and development. This study examined the potential roles of miR-125b in glioma growth. We found that miR-125b promotes glioma cell line growth and clone formation, and protects the glioma cells from apoptosis in vitro. The miR-125b-transfected glioma cells also demonstrated increased growth after in vivo transplantation. We further identified that miR-125b inhibits Connexin43 expression, and the overexpression of Connexin43 antagonizes the effects of miR-125b in cell growth and anti-apoptosis. We conclude that miR-125b regulates glioma growth partly through Connexin43 protein.
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Jin, Z., Xu, S., Yu, H. et al. miR-125b Inhibits Connexin43 and Promotes Glioma Growth. Cell Mol Neurobiol 33, 1143–1148 (2013). https://doi.org/10.1007/s10571-013-9980-1
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DOI: https://doi.org/10.1007/s10571-013-9980-1