References
Agnello D, Bigini P et al (2002) Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis. Brain Res 952(1):128–134
Assandri R, Egger M et al (1999) Erythropoietin modulates intracellular calcium in a human neuroblastoma cell line. J Physiol 516(Pt 2):343–352
Bernaudin M, Marti HH et al (1999) A potential role for erythropoietin in focal permanent cerebral ischemia in mice. J Cereb Blood Flow Metab 19(6):643–651
Bernaudin M, Bellail A et al (2000) Neurons and astrocytes express EPO mRNA: oxygen-sensing mechanisms that involve the redox-state of the brain. Glia 30(3):271–278
Bianchi R, Buyukakilli B et al (2004) Erythropoietin both protects from and reverses experimental diabetic neuropathy. PNAS 101(3):823–828
Brines ML, Ghezzi P et al (2000) Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci USA 97(19):10526–10531
Celik M, Gokmen N et al (2002) Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury. Proc Natl Acad Sci USA 99(4):2258–2263
Chin K, Yu X et al (2000) Production and processing of erythropoietin receptor transcripts in brain. Brain Res Mol Brain Res 81(1–2):29–42
Dame C, Bartmann P et al (2000) Erythropoietin gene expression in different areas of the developing human central nervous system. Brain Res Dev Brain Res 125(1–2):69–74
Digicaylioglu M, Lipton SA (2001) Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature 412(6847):641–647
Digicaylioglu M, Bichet S et al (1995) Localization of specific erythropoietin binding sites in defined areas of the mouse brain. Proc Natl Acad Sci USA 92(9):3717–3720
Ehrenreich H, Hasselblatt M et al (2002) Erythropoietin therapy for acute stroke is both safe and beneficial. Mol Med 8(8):495–505
Ehrenreich H, Weissenborn K et al (2009) Recombinant human erythropoietin in the treatment of acute ischemic stroke. Stroke 40(12):e647–e656
Erbayraktar S, Grasso G et al (2003) Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity invivo. Proc Natl Acad Sci USA 100(11):6741–6746
Feldman L, Wang Y et al (2006) Erythropoietin stimulates growth and STAT5 phosphorylation in human prostate epithelial and prostate cancer cells. Prostate 66(2):135–145
Gorio A, Gokmen N et al (2002) Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma. Proc Natl Acad Sci USA 99(14):9450–9455
Grasso G (2001) Neuroprotective effect of recombinant human erythropoietin in experimental subarachnoid hemorrhage. J Neurosurg Sci 45(1):7–14
Grimm C, Wenzel A et al (2006) Hypoxic preconditioning and erythropoietin protect retinal neurons from degeneration. Adv Exp Med Biol 588:119–131
Jeong J-Y, Feldman L et al (2008) Characterization of erythropoietin receptor and erythropoietin expression and function in human ovarian cancer cells. Int J Cancer 122(2):274–280
Jeong J-Y, Hoxhaj G et al (2009) An erythropoietin autocrine/paracrine axis modulates the growth and survival of human prostate cancer cells. Mol Cancer Res 7(7):1150–1157
Junk AK, Mammis A et al (2002) Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury. Proc Natl Acad Sci USA 99(16):10659–10664
Juul SE, Yachnis AT et al (1999) Immunohistochemical localization of erythropoietin and its receptor in the developing human brain. Pediatr Dev Pathol 2(2):148–158
Koshimura K, Murakami Y et al (1999) Effects of erythropoietin on neuronal activity. J Neurochem 72(6):2565–2572
Marti HH, Wenger RH et al (1996) Erythropoietin gene expression in human, monkey and murine brain. Eur J Neurosci 8(4):666–676
Masuda S, Nagao M et al (1993) Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells. J Biol Chem 268(15):11208–11216
Masuda S, Okano M et al (1994) A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes. J Biol Chem 269(30):19488–19493
Morishita E, Masuda S et al (1997) Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience 76(1):105–116
Nagai A, Nakagawa E et al (2001) Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture. J Neuropathol Exp Neurol 60(4):386–392
Ruscher K, Freyer D et al (2002) Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model. J Neurosci 22(23):10291–10301
Sadamoto Y, Igase K et al (1998) Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery. Biochem Biophys Res Commun 253(1):26–32
Sakanaka M, Wen TC et al (1998) In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci USA 95(8):4635–4640
Sasaki R, Masuda S et al (2001) Pleiotropic functions and tissue-specific expression of erythropoietin. News Physiol Sci 16:110–113
Shingo T, Sorokan ST et al (2001) Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J Neurosci 21(24):9733–9743
Siren AL, Fratelli M et al (2001a) Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci USA 98(7):4044–4049
Siren AL, Knerlich F et al (2001b) Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain. Acta Neuropathol 101(3):271–276
Solar P, Feldman L et al (2008a) Erythropoietin treatment of human ovarian cancer cells results in enhanced signaling and a paclitaxel-resistant phenotype. Int J Cancer 122(2):281–288
Solar P, Koval J et al (2008b) Erythropoietin inhibits apoptosis induced by photodynamic therapy in ovarian cancer cells. Mol Cancer Ther 7:2263–2271
Solar P, Koval J et al (2010) Erythropoietin and ovarian cancer—response. Mol Cancer Ther 9(4):1071
Stolze I, Berchner-Pfannschmidt U et al (2002) Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells. Blood 100(7):2623–2628
Studer L, Csete M et al (2000) Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. J Neurosci 20(19):7377–7383
Sugawa M, Sakurai Y et al (2002) Effects of erythropoietin on glial cell development; oligodendrocyte maturation and astrocyte proliferation. Neurosci Res 44(4):391–403
Suzuki N, Ohneda O et al (2002) Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality. Blood 100(7):2279–2288
Sytkowski AJ (2004) Erythropoietin: blood, brain and beyond. Wiley, Weinheim
Tan CC, Eckardt KU et al (1992) Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia. Am J Physiol 263(3 Pt 2):F474–F481
Um M, Gross AW et al (2007) A “classical” homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y and pheochromocytoma PC-12 cells. Cell Signal 19(3):634–645
Weber A, Maier RF et al (2002) Erythropoietin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures. Brain Res 958(2):305–311
Wustenberg T, Begemann M et al (2011a) EPO treatment preserves gray matter in discrete brain regions of chronic schizophrenic patients: indication of areas with most progressive neurodegeneration inherent to the disease process. Mol Psychiatry 16(1):1
Wustenberg T, Begemann M et al (2011b) Recombinant human erythropoietin delays loss of gray matter in chronic schizophrenia. Mol Psychiatry 16(1):26–36
Yu X, Shacka JJ et al (2002) Erythropoietin receptor signalling is required for normal brain development. Development 129(2):505–516
Zhang J, Wu Y et al (2008) Intravitreal injection of erythropoietin protects both retinal vascular and neuronal cells in early diabetes. Invest Ophthalmol Vis Sci 49(2):732–742
Zhong L, Bradley J et al (2007) Erythropoietin promotes survival of retinal ganglion cells in DBA/2J glaucoma mice. Invest Ophthalmol Vis Sci 48(3):1212–1218
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Sytkowski, A.J. The Neurobiology of Erythropoietin. Cell Mol Neurobiol 31, 931–937 (2011). https://doi.org/10.1007/s10571-011-9695-0
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DOI: https://doi.org/10.1007/s10571-011-9695-0